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Biomedical subjects

M Germain

Publications and source records attributed to M Germain.

At least 127 records · Page 7Linked to original sources
PubMed1979

[Effect of commonly practiced manoeuvres in vascular microsurgery. Study under the scanning electron microscope (author's transl)].

The authors studied in 100 Wistar rats the manoeuvres that may commonly be carried out during vascular microanastomosis of diameter less than 3 mm (aorta and posterior vena cava): clamping for 30 to 45 minutes, bipolar electrocoagulation of the collateral arteries, more or less marked pinching of the vascular wall. The risk of thrombosis seems all the greater when: --the surgeon is inexperienced: viz. trauma with the forceps, parietal tears at the level of the stitches, two many threads passed for hemostasis (all these factors accentuate the fibrinoid and platelet deposits); --bipolar electrocoagulation of a collateral artery applied too close to the vessel to be anastomosed (less than 1 mm.)The formation of a smooth and regular fibrinous pseudo-intima appears within 48 to 72 hours which may explain the elective onset of thromboses before this delay.

Animals↗
PubMed1979

[Acute primary ischemic enteritis and colitis. Clinico-pathological and physio-pathological findings].

By opposition to acute post-operative ischaemic enterocolitis, the authors isolate, with the aid of seven cases, the intestinal lesions which spontaneously occur on the small intestines and on the colon and due to an ischaemic mechanism without thrombosis of the mesenteric vessels. After the description of clinical and anatomical features, they point out the main part of the vascular factor in the genesis of the lesions.

Aged↗
PubMed1979

[Esophago-jejunostomy at the level of the neck for restoration of continuity in carcinoma of the esophagus (after esophageal resection or for palliative reasons) (author's transl)].

A technic of esophago-jejunostomy in the neck is described which uses a Y loop, to which is given a further blood supply through the internal mammary vessels, united to the vessels of the transplanted loop through microsurgical anastomoses. This technic is used either for purely palliative reasons or when the esophageal tumour has become inoperable, or after esophagectomy as a procedure for reconstruction of the digestive tract.

Esophageal Neoplasms↗
PubMed1978

[The gastro-intestinal effects of portal hypertension. Role of highly selective vagotomy. Experimental study in the rat (author's transl)].

Portal hypertension was obtained by portal ligature in the rat by an original procedure. Hemodynamic and pathological studies were performed at the end of the 4th postoperative month. Portal hypertension causes macroscopic and histological lesions in particular in the stomach and small intestine. The lesions observed were superficial desquamation, interstitial oedema, submucosal fibrosis, ulcers, and superficial or total necrosis of the intestine. Splenic fibrosis with congestion of the medullary sinuses is usual. A collateral circulation towards the liver and caval system develops rapidly. We never observed oesophageal varices. The main cause of splanchnic modifications was vascular stasis to which should perhaps be added humoral changes. Highly selective vagotomy does not protect the splanchnic area against lesions induced by portal ligature.

Animals↗
PubMed1978

[Carcinomas of the transverse colon. A series of 75 cases (author's transl)].

The authors report a series of 75 cases of carcinoma of the transverse colon, involving equally the right and left halves. They rarely arose from the middle segment (10% of the series). Usually the tumour was very large affecting the serous layer with lymph node invasion. Liver metastases were frequent. 50% of patients were aged over 70 years. Theoretically, wide removal attempting to cure the disease means removing both colonic angles and the areas supplied by both the superior and inferior mesenteric arteries. But fairly often the existence of vascular variations in the transverse mesocolon permits one to restrict the extent of the resection whilst saving the basic principles of radical removal. Furthermore, in 20% the treatment was purely palliative. The operative mortality was high (25%). The five year survival, in the whole series was about 50%.

Aged↗
PubMed1977

[Gingival metastasis of a malignant bronchial carcinoid tumor. Apropos of 1 case].

Secondary tumors of the mouth are rare and especially seated on the maxillaries. Metastasis to the soft tissues of the mouth, especially of cancers situated far from ORL and buccal areas are exceptional. The authors report an observation of a bronchial carcinoïd tumor with metastasis to the gums in a 24-year old man. The rapidity of the evolution of the tumor, the precocity and the very exceptional site of the metastasis as well as certain particularities of the histological pattern of the primitive bronchial tumor, once again states the problem of the confines with the Oat-Cell Carcinomas.

Adult↗
PubMed1977

[Effects of stress and highly selective vagotomy on mast cells in the wall of the rat stomach (author's transl)].

Quantitative changes in the gastric mast cells in ulcer diathesis and especially in the development of acute ulceration have already been studied. Qualitative changes may be asse-sed by Alcian Safranin blue stain which permits one to distinguish two sub groups: the blue mast cells and the red mast cells, which alone undergo degranulation. This report describes the modifications in number and aspect of the mast cells of the stomach of the white rat after stress due to restraint at variable intervals after highly selective vagotomy. The density of the mast cells and their appearance depend partly on vagal nerve supply. After highly selective vagotomy, their density increases while the initially unbalanced proportion of red and blue mast cells becomes normal in the long term. After stress, there is a reduction in the number of mast cells and, above all, disappearance of the red forms whether the rats are vagotomised or not. This study takes into consideration multifactorial problems which intervene in the etiology of stress ulcers and the necessity of continuing the study of the consequences of vagotomy.

Animals↗
PubMed1977

[Eosinophil ileitis (author's transl)].

Eosinophilic ileitis is observed mainly in three coastal areas: Holland, Japan and Brittany. It presents in the form of a parietal inflammation, stenosing the intestinal lumen or a sessile tumour of limited volume. The symptoms are generally those of appendicitis but a past history of allergy and the discovery of eosinophilia greater than 10 p. cent may lead to the diagnosis of eosinophilic granuloma which only histology can confirm. Surgical treatment consists of segmental resection of the small intestine. The pathogenesis of the granuloma, which was for long attributed to the presence in the wall of the intestine of ascaris larvae, is at present debated. Are there non-parasitic eosinophilic granulomas? The case reported here is perhaps an example.

Adolescent↗