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Biomedical subjects

M Gangemi

Publications and source records attributed to M Gangemi.

At least 91 records · Page 5Linked to original sources
PubMed1981

GnRH--test in menopause. Its possible use in identifying the subjects at risk for dysplastic endometrial pathology.

The Authors, after reviewing the results of their previous studies on the endocrine situation in post-menopausal endometrial carcinoma and considering what emerges from the present work, suggest GnRh-Test as a mean to better identify the subjects at risk for this neoplasia; in patients already affected with endometrial cancer, it could be an indirect index in recommending or not endocrine therapy.

Aged↗
PubMed1981

"Euthyroidal' goiter and menstrual disorders.

We selected 5 patients, between 18 and 31 years of age, presenting menstrual irregularities and thyroidal goiter with no apparent functional change (normal, T4 and T3 tests). These patients underwent further examinations: TSH (basal and after TRH stimulation), HPRL (basal-circadian rhythm and after TRH stimulation), FSH and LH (basal and after Gn-RH stimulation), thyroidal scintiscan, search for antithyroid antibodies. Basal and post-stimulation TSH was fundamental in 2 cases of subclinical hypothyroidism. The positive antibody search confirmed the antoimmune origin. In the same patients, the HPRL circadian rhythm and TRH test highlighted a secondary hyperprolactinemia which would not have been revealed by a single basal sample.

Adolescent↗
PubMed1981

Bromoergocriptin therapy in eumenorrhoic patients presenting galactorrhea.

Eleven eumenorrhoic patients presenting galactorrhea were subjected to a three-month Bromoergocryptin therapy (2.5 mg/os/die). Prolactin Circadian Rhythm, performed on all patients, showed four hyper and seven normoprolactinemic cases. The mammary condition was studied, before and after treatment, through clinical examination, mammary cytology and thermography. Hyperprolactinemic patients responded positively to the therapy, showing subjective, clinical and thermographic improvement. Conversely, normoprolactinemic patients, though showing a noteworthy improvement of symptomatology and galactorrhea, did not respond equally well from the objective and thermographic points of view.

Adult↗
PubMed1981

Inadequate luteal phase and benign breast disease.

The Authors compare E2 and Progesterone plasma levels in the luteal phase of twelve normally menstruating women whose basal body temperature curves were biphasic and in which breast micronodularity and mastodynia were present, with those of ten breast disease-free controls. The significant difference (p less than 0.001) found in Progesterone levels gives strength to the opinion that Progesterone supply therapy can effectively improve both mastodynia and the clinical picture objectively documented.

Adult↗
PubMed1980

Estrogen therapy in menopause and endometrial cancer.

The hormone dependency of endometrial cancer and the increase of its incidence seem to be generally accepted. The Authors expose the results of a four year retrospective epidemiological research aiming at verifying the possible role of menopausal estrogen assumption in the etiopathogenesis of the above mentioned disease. Two groups of post-menopausal patients were examined, who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy: 168 were endometrial cancer free, 50 were affected. The percentages of estrogen users, the exposition time and type of therapy were carefully analyzed in them. No correlation could be found between estrogen consumption, which resulted much lower than in the U.S.A., and endometrial cancer incidence. The relatively short assumption times, the different drug associations, and the hypoestrogenic origin of the most disturbing menopausal symptoms can help to explain this finding which is however, in agreement with what emerges from studies carried out in different countries by several Authors.

Estrogens↗
PubMedDate not supplied

Hydrocephalus combined with congenital cataract and microphthalmia.

We describe a case of bilateral microphthalmia with bilateral congenital cataracts associated with hydrocephalus in a 9-month-old girl with consanguineous parents. The differential diagnosis included: (1) congenital rubella syndrome; (2) congenital toxoplasmosis; (3) chromosome alterations; and (4) metabolic disease. However, negative clinical, laboratory, and instrumental investigations excluded all of these hypotheses. We stress the usefulness of echography in establishing whether or not infection has occurred during intrauterine life.

Cataract↗
PubMedDate not supplied

Megadolichobasilar anomaly. Clinical and diagnostic considerations on 30 cases.

30 patients with megadolichobasilar artery, explored by angiography, are reported; 23 among them were first studied by computerized tomography and 4 by magnetic resonance. From the clinical point of view, 9 had transient ischemic attacks or definitive ischemia, 7 had subarachnoid or intracerebral hemorrhage, and 7 had deficits of the cranial nerves; in the other 7 cases the condition was incidentally discovered as isolated asymptomatic anomaly or with other unrelated lesions. Among the patients with ischemic symptoms, vertebrobasilar insufficiency and pontine infarction were the most common clinico-radiological findings. Among the patients with intracranial hemorrhage, four had associated aneurysm or arteriovenous malformations. CT and MR allow a correct diagnosis of this anomaly. MR seems to be superior to CT in delineating the relationship of the anomalous artery with the nervous structures, and the coexisting pathology.

Aged↗
PubMedDate not supplied

Cavernous angioma of the pineal region.

The pineal region is one of the most rare localizations of intracranial cavernous angiomas, with only 8 cases reported up today. The Authors report a case of cavernous angioma of such localization and review the pertinent literature. Magnetic resonance allows the correct diagnosis of cavernous malformations on the basis of their typical aspect, even in the absence of histological verification. We suggest that this imaging technique will allow to identify more frequently pineal cavernomas preoperatively, thus avoiding useless irradiation.

Brain Neoplasms↗
PubMedDate not supplied

[Prolactinoma and pregnancy].

The problem of pregnancy in women affected by prolactinosecreting adenoma has been evaluated and tackled in a variety of different ways over the course of the past twenty years. The early years were marked by an alarmist attitude which saw pregnancy as a considerable risk due to the expansion of the hypophyseal tumour, and women were advised against pregnancy or even to abort. Later, this was superceded by cautious observation and close monitoring. Recently, and above all with reference to microadenomas, there is a growing belief that pregnancy does not represent a real risk but can even lead to the definitive remission of hyperprolactinemia in a certain percentage of women.

Female↗