Search PubMed⌕ Search

Biomedical subjects

M G Dodson

Publications and source records attributed to M G Dodson.

48 records · Page 3Linked to original sources
PubMed1981

Distinction of the phenotypes of in vitro anchorage-independent soft-agar growth and in vivo tumorigenicity in the nude mouse.

The growth characteristics of LT-2 cells, an epithelial squamous cell carcinoma, clearly separate the phenotypes of anchorage-independent growth in soft agar and tumor formation in vivo. LT-2 readily grows and forms tumor nodules in the nude mouse but does not proliferate anchorage independently in soft agar. This distinction is confirmed by the observation that cells explanted from nude mouse tumor nodules and cultured in vitro still do not clone in soft agar. The human origin of tumor nodule cells was confirmed by karyotyping. LT-2 cells have an aneuploid karyotype which has persisted for 4.5 years in culture with considerable variation in chromosomal number. Passage through the nude mouse did not select for any "tumor" clone since marked chromosomal variation was still noted by cells explanted from tumor nodules. Tumor cells formed a well-differentiated skin with keratin formation in the nude mouse despite wide karotypic variations of cells and years of in vitro culture. Strict monolayer growth was noted by LT-2 cells when grown in culture flasks and also by cells explanted from tumor nodules, indicating that monolayer growth and nude mouse tumorigenicity are also separate phenotypes.

Agar↗
PubMed1978

Behcet syndrome: with immunologic evaluation.

A case of Behcet syndrome with immunologic evaluation, including screening of a vulvar ulcer for IgG, IgM, IgA, and fibrinogen by direct fluorescent microscopy is presented. Attempts were made to demonstrate cellular and humoral immune responses to mucosal antigens by lymphoblast transformation in the presence of cadaver esophageal mucosal extracts and indirect immunofluorescence using autologous serum and mucosal tissue. Serial measurements of percentages of total T, active T, and B lymphocyte populations, and lymphocyte response to phytohemagglutinin (PHA) stimulation during the course of Behcet syndrome are also presented. Clinical evaluation, histology of a Behcet vulvar ulcer, and a 2-year followup with good response to chlorambucil are reviewed.

Adult↗
PubMed1978

Adenoid cystic carcinoma of the vulva. Malignant cylindroma.

A case of adenoid cystic carcinoma (cylindroma) of the vulva is presented, reviewing the clinical course and response to therapy over a 5-year period. Only 9 previous cases had been reported by 1963. Several sources of cell origin had been previously suggested. Findings and histology in this case support a relation to a similar tumor occurring in other sites of the upper respiratory tract and salivary gland.

Carcinoma, Adenoid Cystic↗
PubMed1978

Psychosomatic vulvovaginitis.

Psychosomatic vulvovaginitis is a real clinical entity that should be suspected in any patient whose vaginal complaints do not correlate with the physical findings. Such patients have usually seen multiple physicians, are "allergic" to most vaginal medications, and exhibit signs of emotional lability. In many cases, psychiatric evaluation and therapy can be of great benefit.

Adult↗
PubMed1977

T and B cells in pregnancy.

The present study reports on the relative percents and absolute numbers of peripheral blood total T, active T, and B lymphocytes in pregnant women throughout gestation. These data agree with other studies reporting normal T and B cell populations during pregnancy.

Adult↗
PubMed1977

Unusual protozoal infestation of the cervical mucus.

The transient colonization of the female genital tract with an unusual multiflagellated protozoan is reported. The presence of active organisms in large numbers in the mucus of the endocervical canal and their absence from the gastrointestinal tract and other areas indicates true colonization rather than contamination. The colonization resolved spontaneously. The organism has been classified as a Polymastigidan.

Adult↗
PubMedDate not supplied

The polymicrobial etiology of acute pelvic inflammatory disease and treatment regimens.

Continued research on acute pelvic inflammatory disease (PID) has demonstrated that PID has a rather remarkably varied etiology, the pathogens responsible including Neisseria gonorrhoeae, Chlamydia trachomatis, aerobic and anaerobic gram-positive and gram-negative organisms, and possibly mycoplasmas. There is clearly no single antimicrobial agent that is effective against all of the organisms implicated in the etiology of acute PID. The aminoglycosides, generally in combination with an antibiotic such as clindamycin, are commonly used in the treatment of patients with acute PID. The combination of a new monocyclic beta-lactam antibiotic, aztreonam, and clindamycin may be less toxic and equally or more effective for the treatment of acute PID.

Anti-Bacterial Agents↗