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Biomedical subjects

M G Bousser

Publications and source records attributed to M G Bousser.

At least 217 records · Page 12Linked to original sources
PubMed1988

Combined low-dose acetylsalicylic acid and dihydroergotamine in migraine prophylaxis. A double-blind, placebo-controlled crossover study.

The efficacy of the combination of dihydroergotamine (10 mg) with acetylsalicylic acid (80 mg) (DHE + ASA) in the prophylaxis of migraine was studied in a double-blind, placebo-controlled crossover trial (8 weeks twice). Of 45 patients who entered the study, 38 completed it. The number of attacks was significantly (p = 0.003) reduced during active treatment (11.5 +/- 6.2) compared with placebo (16.6 +/- 9.9). The mean duration, the mean severity, and the mean score for symptomatic acute medication of attacks did not differ significantly. The overall assessment made by the patients themselves was in favor of DHE + ASA (p = 0.001). These results indicate a moderately beneficial effect of the dihydroergotamine/low-dose acetylsalicylic acid combination in migraine prophylaxis.

Adolescent↗
PubMed1988

Duplex scanning in extracranial vertebral artery dissection.

Ultrasonic (duplex scanning and continuous-wave Doppler) and angiographic findings in three patients with bilateral extracranial vertebral artery dissection are reported. A pattern of ultrasonic anomalies diagnostic of dissection is described, including association of a localized increase in diameter of the artery with hemodynamic signs of stenosis or occlusion at the same level and decreased pulsatility and presence of intravascular echoes in the enlarged segment.

Adult↗
PubMed1988

[Neurological manifestations of Behçet's disease].

Characterised classically by the association of buccal and genital ulceration and uveitis with hypopyon, Behçet's disease has many other manifestations, amongst which the neurological ones (often referred to as Neuro-Behçet) are important in view of their frequency and their gravity. Anatomically, it produces a subacute haemorrhagic and necrotising meningo-encephalitis, which most typically effects the hypothalamus and brainstem. Clinically, there is extreme polymorphism, central manifestations being the most frequent: seizures, organic brain syndromes, disorders of consciousness, aphasia, hemiplegia, cranial nerve palsies, pseudobulbar and extrapyramidal syndromes and meningism. The peripheral nerves and muscles are rarely affected. Alongside Neuro-Behçet per se, attention has recently been directed to the various cerebro-vascular manifestations, dominated by venous thrombosis. A review of the principal neurological manifestations is given, with comment on anatomico-pathological aspects, clinical presentation, investigational techniques, diagnostic difficulties, prognosis, and treatment.

Behcet Syndrome↗
PubMed1988

[Dysarthria-clumsy hand syndrome caused by cerebellar infarction].

A 80 year old woman suddenly complained of dysarthria and clumsiness of the right hand. CT scan showed an infarct in the territory of the lateral branch of the right superior cerebellar artery. This dysarthria-clumsy hand syndrome in a patient with paroxysmal atrial fibrillation suggests that the likely cause was an embolus from the heart.

Aged↗
PubMed1988

[Pure sensory stroke caused by thalamic hematoma].

A 59-year-old hypertensive patient presented with dysesthesias and a pure sensory deficit involving face, arm and leg on the left side of the body. CT scan and MRI showed a small hematoma in the posterior and lateral part of the right thalamus.

Hematoma↗
PubMed1987

Prevalence of asymptomatic internal carotid artery stenosis.

The prevalence of internal carotid artery stenosis was studied with continuous wave Doppler and Duplex scanning in 526 subjects aged 45-84 years of age. They were devoid of any cerebrovascular symptoms or signs and were not referred to us because of risk factors or manifestations of atherosclerosis. The prevalence of stenosis, whatever the grade, was low in both sexes aged under 65 years: 2.4% in males aged 55-64 years. It increased sharply with age, reaching 30.3% for stenosis of less than 50% and 6.1% for stenosis of greater than 50% in males aged 75-84 years. The prevalence of minimal lesion (plaque with less than 15% diameter reduction) was high: 32.1% in males aged 45-54 years and 48.5% in the 75- to 84-year age range.

Aged↗
PubMed1987

Drug trials in migraine. The clinician's view on end points.

The definition of efficacy parameters in drug trials of migraine has received little attention and the tendency has been to take into account many parameters, which leads to the possibility of some positive results being obtained purely by chance. In trials of prophylactic drug treatment, the major parameter is the frequency of attacks. Patients with frequent interval headache should preferably be excluded from such trials since there is no satisfactory way to distinguish interval headache from mild migraine attacks. Severity and duration of attacks are important parameters but they are difficult to interpret since they are modified by symptomatic medication. The mean score of each attack by consumption of symptomatic medication gives a good estimate of the severity and duration of attacks, but the problem of equalizing different medications in order to obtain a single estimate has not been solved. In trials of abortive drug treatment, there is at present no agreement upon the single most important parameter. Severity of headache, severity of associated symptoms, global efficacy and duration of attacks are all modified by escape medication. The need for escape medication is a better parameter but its power to discriminate ineffective and partially effective drugs is low. It is suggested that the major parameter could be the number of attacks aborted in 2 h or less, which is a simple quantitative and clinically relevant criterion.

Clinical Trials as Topic↗
PubMed1987

[Dissecting aneurysm of the extracranial vertebral arteries and pregnancy].

A 32-year-old woman was at the end of her first and-until then normal-pregnancy, when she abruptly experienced a severe neck pain. Delivery was provoked two days later but a week after she suddenly developed a left lateral medullary syndrome. Angiography disclosed a severe diffuse and irregular narrowing of both vertebral arteries in their second and third segments, typical of dissecting aneurysm. The patient was treated with heparin and made a partial recovery. A second angiography nine months later showed a normal left vertebral artery while the right one was probably occluded.

Adult↗