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Biomedical subjects

M Furlanut

Publications and source records attributed to M Furlanut.

At least 73 records · Page 4Linked to original sources
PubMed1985

Orphenadrine serum levels in a poisoned patient.

A patient ingested about 5 g of orphenadrine hydrochloride. He had gastric lavage and oral administration of activated charcoal. The main symptoms were neuropsychiatric in nature. Possible relation between serum levels of the drug and time course of the toxic effects are described.

Adult↗
PubMed1985

Absorption and disposition kinetics of flunoxaprofen and benoxaprofen in healthy volunteers.

Flunoxaprofen is a new nonsteroidal antiinflammatory agent that, like benoxaprofen, inhibits leukotriene rather than prostaglandin synthesis. The absorption and disposition kinetics of flunoxaprofen and benoxaprofen have been compared in six healthy volunteers after oral administration of 100 mg of each drug. The two drugs showed similar absorption characteristics, whereas the distribution and elimination processes were much faster for flunoxaprofen. The renal route of elimination appeared to contribute significantly less to the disposition of flunoxaprofen. These kinetic characteristics render less likely the risk of excessive drug accumulation with flunoxaprofen, especially in the presence of reduced renal function.

Adult↗
PubMed1984

Cyanotic crises in a breast-fed infant from mother taking dipyrone.

Cyanotic crises occurred in a breast-fed infant whose mother was under treatment with dipyrone for a sore throat. No abnormalities were found at physical and routine laboratory examinations. Dipyrone concentrations in mother's serum and milk and in infant's serum and urine were 3.3, 4.3 and 3.2, 3.74 micrograms/ml respectively. It is concluded that the adverse effect could be due to dipyrone ingested with mother's milk.

Adult↗
PubMed1983

Tolerability and serum levels of benoxaprofen in healthy volunteers.

Tolerability, serum levels and urinary excretion of benoxaprofen (B) in therapeutic doses of 400 or 600 mg as a capsule were studied in 22 healthy volunteers after single or multiple doses. B was determined by a HPLC procedure. Apart from a skin reaction in one patient, no major problems were encountered by patients. Mean serum peak values after 400 and 600 mg were 49.84 and 94.54 micrograms/ml respectively. Mean time to peak was 5.6 hours and mean half-life ranged between 45.38 (400 mg regimen) and 63.48 hours (600 mg regimen). Urinary excretion was only a fraction of the doses ingested: 14.39% after a single dose; 35.5% after multiple doses. This may depend on other pathways of elimination of the drug because steady state is reached according to half-life.

Adult↗
PubMed1978

Effects of folic acid on phenytoin kinetics in healthy subjects.

Phenytoin (DPH) disposition was studied in normal subjects before and after treatment with folic acid for 14 days. Our results suggest that folic acid lowers (DPH) serum levels without significantly modifying its bound fraction and increases the rate of DPH and meta-hydroxydiphenylhydantoin excretion in urine.

Adult↗
PubMed1975

[Effects of verapamil on the electrical and mechanical activity of smooth muscle].

Verapamil inhibited both the electrical and the mechanical activity of isolated guinea-pig taenia coli. The action of the drug was similar in some respects to that of quinidine as far as the electrical activity was concerned. Closer similarities were observed between it and diphenylhydantoin. The conclusion is drawn that the drug has points of attack at the electromechanical junction and the membrane.

Action Potentials↗
PubMed1975

Effects of quinidine and diphenylhydantoin on membrane resistance in smooth muscle.

The effects of quinidine and diphenylhydantoin on the membrane electrical resistance of guinea-pig taenia coli have been studied by means of the double sucrose gap tachnique. At concentrations ranging from 2 to 7.10-minus 5 quinidine induces an evident dose-related increase of membrane resistance, as indicated by the increase of the electrotonic potential. These effects are unaffected by tetrodotoxin (10(-6)) and in the presence of various changes of ionic environment (replacement of Na by Li, increase of K or Ca or Mg concentrations). Only a concomitant rise of both K and Ca (or Mg) can prevent the effects of quinidine on membrane resistance. The rate of repetitive discharge under sustained electrical depolarization is not affected by quinidine, at concentrations increasing membrane resistance. The experiments with diphenylhydantoin showed that this drug is practically ineffective on membrane resistance, but induces a decrease of the rate of repetitive discharge under sustained depolarization.

Animals↗