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Biomedical subjects

M Furia

Publications and source records attributed to M Furia.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Surgical treatment of eye wounds with retinochoroidal metal foreign bodies. Apropos of 6 cases].

Six cases of intra-ocular metallic foreign bodies located into the retino-choroidal wall are presented. A surgical treatment was performed, and included a vitrectomy, a foreign body extraction with intraocular forceps, a primary or a secondary scleral buckling for the peripheral wound, and a retino-choroidectomy for one of the posteriorly located foreign bodies. In all the cases, we observed a cicatricial retraction of the retino-choroidal wound. When the wound was peripheral, the retina detached in the cases without buckling and it was necessary to do a secondary scleral buckling procedure. When the wound was located at the posterior pole, the retina remained flat in one case, with a 6 mm metallic body, probably because of the relaxing retinotomy performed to extract the foreign body. We think that it is better to perform a primary scleral buckle of the peripheral wounds. The various aspects of the treatment are discussed.

Adult↗
PubMed1986

Dosage compensation at the sgs4 locus of Drosophila melanogaster.

The X-linked sgs4 gene of Drosophila melanogaster encodes a salivary glue protein. Non-dosage-compensated alleles of this gene have been described by G. Korge, in which males accumulate only about half of the Sgs4 polypeptide as do females. We show that the Sgs4 mRNA levels in dosage-compensated and non-dosage-compensated strains parallel the levels of Sgs4 polypeptide. Korge's genetic analysis of one of the non-dosage compensated alleles suggests that dosage compensation is controlled by sequences that lie 5' to the coding region. Sequences important for regulating the absolute levels of transcription of sgs4 have been identified as residing within a region of 600 base-pairs 5' to the site of transcription initiation. We have sequenced this region from two non-dosage-compensated strains and find no significant deviation from the sequence of dosage-compensated alleles. We therefore conclude that sequences that act to mediate the dosage compensation of sgs4 must lie outside this 600 base-pair region.

Animals↗
PubMed1985

[Chorioretinopathy caused by migration of caterpillar hairs. Apropos of 2 cases].

Caterpillars cause many ocular lesions by a pathogen agent coming from their coating: the hairs. These can enter into the eye ball and migrate in the ocular tissues; a secondary inflammatory reaction to the foreign body will appear. This reaction is due to the hairs themselves as foreign body, but also partly to their contents: a liquid toxin which contains proteins, lipids and other components. The morphological configuration of the hair favours its migration in the tissues. Among the different lesions observed, chorio retinopathies are not very frequent, but their clinical aspect is quite characteristic and they are easier to recognize when they are associated with intra crystalline caterpillar hairs. Two cases of chorio retinopathies had been recorded. Both had hairs inside the lens and important hyalitis. One had the very characteristic "track-shaped" scars in the eye-fundus. The other had a focal chorio retinitis above the inferior temporal artery and developed a retinal tear. Local and general corticotherapy was applied, but the effect was not adequate. Vitrectomy was performed in the two patients with a good functional result. This seems to prove that vitrectomy may be useful for the important hyalitis secondary to the intra ocular migration of caterpillar hairs.

Adolescent↗
PubMed1984

[Retinopexy by endodiathermocoagulation].

Retinopexy was performed by endodiathermy coagulation around a retinal tear provoked during dissection of epiretinal membranes. The dissection was a complement to vitrectomy for Candida albicans endophthalmia. The choice of this technique was dependent on the absence of need for the laser, and allowed an internal buffering to be carried out by the use of silicone oil. Angiography showed depigmented areas confirming the presence of scar tissue as seen in experimental rabbit studies. The scar involved the whole thickness of the retina and choroid adjacent to the cauterized pigmented epithelium. This method is simple and possesses the advantage of being able to be used when the perioperative laser beam is unable to cross the transparent media of the eye.

Candidiasis↗
PubMed1984

[Favorable development of bilateral Candida albicans endophthalmitis. Value of early vitrectomy].

A chronic bilateral endogenous Candida albicans endophthalmitis in a heroin addict was treated by vitrectomy, argon laser photocoagulation and endodiathermy. In the left eye with a visual acuity of 6/6 there was a totally asymptomatic retinal tear due to vitreous traction. The eye was treated by argon laser photocoagulation immediately, and then underwent a vitrectomy several weeks later. Analysis of the vitrectomy specimen was negative for any organism. In the vitreous of the right eye a "fungus ball" was noted nasally. Visual acuity was also 6/6. Fluorescein angiography demonstrated the presence of a small area of retinal involvement above the optic disc. During vitrectomy and membrane peeling the area of retinal involvement was torn away. The tear was then treated by endodiathermy. Vitreous analysis showed the presence of Candida albicans, sensitive to 5-fluorocytosine which was then used in treatment. All other cultures and stains were negative for Candida. The patient had negative serology for Candida, but normal immune responses based on cutaneous testing to several antigens and dosage of serum immunoglobulins and complement. A negative serology to Candida is most likely explained by the supposition that an episode of blood stream infection occurred only briefly and long before the eye involvement became clinically significant. At 4 months after bilateral vitrectomy, the patient has maintained 6/6 vision in each eye.

Adult↗
PubMed1982

A study of rDNA magnification phenomenon in a repair-recombination deficient mutant of Drosophila melanogaster.

The rDNA magnification process consists of a rapid and inheritable rDNA increase occurring in bobbed males: in a few generations the bb loci acquire the wild-type rDNA value and reach a bb+ phenotype.--We have analyzed the rDNA magnification process in the repair-recombination-deficient mutant mei9a, both at the phenotypical and rDNA content levels. In mei9a bb double mutants the recovery of bb+ phenotype is strongly disturbed and the rDNA redundancy value fails to reach the wild-type level. The strong effect of this meiotic mutation on rDNA magnification suggests a close relationship between this phenomenon and the repair-recombination processes.

Animals↗
PubMed1979

Patterns of reversion to bobbed condition of magnified bobbed loci in D. melanogaster.

The number of genes coding for the ribosomal RNA (rDNA) can increase in D. melanogaster by means of a process called magnification. In this way, a partial deletion in this locus, termed bobbed, can reach a wild type condition. A newly magnified locus, in turn, reverts to a deficient bobbed condition if it is kept in a phenotypically wild type genotype for several generations. We studied bobbed loci at different magnification steps, analysing their behaviour through the reversion process and the way they carry out a second round of magnification. Results based on the analysis of the reversion process led to the conclusion that magnification consists of a progressive integration into the bobbed locus of free rDNA copies. Moreover, evidence is supplied that the extent of this integration affects the way a reverted locus goes through a second magnification cycle. The extensive characterization of reverted bobbed loci lends substantial support to the extra copies model of rDNA magnification.

Animals↗
PubMed1979

Identification of a DNA polymerase beta-like form in Drosophila melanogaster adult flies.

DNA polymerase beta is widely distributed in the eukariotes. So far, few examples are known in which a DNA polymerase alpha -like form alone is reported. Surprisingly, DNA polymerase beta was not detected in Drosophila embryos, while it is present in the cells of multicellular species from sponge to mammals. In view of the relevance of Drosophila as a model biological system for studying the role of the various DNA metabolism enzymes in vivo we have reinvestigated the presence of the DNA polymerase beta-like form in Drosophila adult flies. Here we report the occurrence in Drosophila melanogaster adult flies of a DNA polymerase activity that, for its NEM(1) resistance, template specificity, sensitivity to ddTTP, sedimentation coefficient and nuclear localization can be classified as a beta-like form.

Animals↗