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Biomedical subjects

M Fukui

Publications and source records attributed to M Fukui.

At least 703 records · Page 39Linked to original sources
PubMed1980

Ciliated and goblet cells in craniopharyngioma. Light and electron microscopic studies at surgery and autopsy.

A case of a suprasellar epithelial cyst in a 48-year-old man is reported. The cyst was lined with two different types of stratified epithelium: one was two to three or more layers of squamous cells with overlying ciliated columnar cells and goblet cells at the surface and the other was tyical stratified squamous epithelial cells. The tumor was neither a pure Rathke's cleft cyst nor a typical craniopharyngioma but was considered essentially to be a craniopharyngioma with ciliated columnar cells and goblet cells. Thus it might be considered a mixed form of these two tumors. This case indicates the close relationship between craniopharyngiomas and Rathke's cleft cysts.

Autopsy↗
PubMed1980

Irradiated meningiomas: a clinical evaluation.

Eighteen cases of intracranial meningioma that received preoperative or postoperative irradiation with 60Cobalt or Linac have been reviewed. Eight patients received preoperative irradiation because their tumours were very large, hypervascular, and surgically not readily accessible. Two angioblastic meningiomas of the haemangiopericytoma type responded well to irradiation and were easily extirpated. One of these developed a local recurrence and metastases to the lungs and liver nine years after surgery. The recurrent intracranial tumour and nodules in the lungs responded well to irradiation. The other six cases of meningiomas of meningothelial, transitional, or haemangioblastoma types, did not improve clinically or radiologically after irradiation. Ten cases received postoperative irradiation because their tumours were only partially removed or were histologically malignant. In all cases irradiation was most effective for recurrent tumours of the haemangiopericytoma type. This study indicates that irradiation is useful in tumours of the haemangiopericytoma type as an adjunct to surgery or for palliation in advanced stages. Irradiation may been effective in supressing recurrences in two cases of other types of meningioma, although the number of cases is too small to allow any definite conclusion.

Adult↗
PubMed1980

Prolonged injection angiography for diagnosing intracranial neoplasms.

Prolonged injection angiography (PIA), in which large amounts of contrast material are administered for three or four seconds, was used to visualize the vasculature of 70 intracranial neoplasms. Tumor stains were demonstrated better with or solely by PIA in all pituitary adenomas with suprasellar extension and in most meningiomas. PIA was less effective in tumors with marked arteriovenous shunts or in low-grade gliomas. PIA is especially indicated when avascular or hypovascular masses are encountered on conventional angiography or when contrast enhancement is encountered on computed tomography (CT). PIA is also indicated to demonstrate neoplasms which are not enhanced with contrast media on CT since PIA demonstrates the venous anatomy surrounding the tumors especially well.

Adenoma↗
PubMed1980

Radiosensitive meningioma.

A hugh intracranial angioblastic meningioma responded well to preoperative irradiation. The indication for preoperative irradiation of hypervascular and inaccessible meningiomas is discussed.

Adult↗
PubMed1980

Antitumor activities of newly synthesized 5-carbamoyl-1 H-imidazol-4yl 1-adamantanecarboxylate and 5-carbamoyl-1H-imidazol-4yl piperonylate.

In synthetic studies on the chemical modification of the nucleoside antibiotic bredinin, two new derivatives, 5-carbamoyl-1H-imidazol-4-yl 1-adamantanecarboxylate and 5-carbamoyl-1H-imidazol-4-yl piperonylate, were found to possess a potent antitumor activity in several experimental tumor systems, even though bredinin itself shows only in vitro cytotoxicity and thus lacks therapeutic effectiveness. These two derivatives of bredinin exhibited antitumor activity against a wide variety of tumors, including leukemias L1210 and P388, Lewis lung carcinoma, B16 melanoma, Colon 26 and 38 adenocarcinomas. Ehrlich carcinoma, and Sarcoma 180. It is noteworthy that these agents showed good therapeutic effects not only against ascitic types of tumors but also against a number of slow-growing solid tumor lines, particularly the ascitic and solid forms of Ehrlich carcinoma. At their optimal doses, both compounds effected a complete cure of all or most of the mice treated. Although the mechanisms of action of these compounds remain unknown, they are able to suppress in vivo tumor growth, presumably by being slowly anabolized in vivo to an active form and inhibiting purine de novo synthesis as bredinin does.

Animals↗
PubMed1979

Prolonged injection angiography for diagnosing intracranial cavernous hemangiomas.

A case of intracranial cavernous hemangioma displaying feeding arteries, tumor stains, and venous pools is presented. Tumors of this type may simulate avascular masses on angiography; however, when surgically excised, they bleed profusely. A correct preoperative diagnosis can help avoid unnecessary incisions. Prolonged injection angiography clearly depicts the tumors and their venous pools, which may be pathognomonic of cavernous hemangiomas.

Adult↗
PubMed1978

Angiographic diagnosis of fourth ventricle tumors.

Twelve primary fourth ventricle tumors and 22 medulloblastomas occupying mainly the fourth ventricle were analyzed, with emphasis on the differential diagnosis, vascularity, and some unusual findings. Though both types of tumor often have identical manifestations, the correct diagnosis can be made in most cases by careful evaluation of the posterior inferior cerebellar artery, particularly the choroidal and nodular branches. Unusual findings in primary fourth ventricle tumors mimicking tumors of the pons and medulla oblongata are described, and possible explanations for these findings are discussed. The results of this study underscore the importance of angiotomography in the diagnosis of tumors of the fourth ventricle.

Adult↗
PubMed1978

Extracerebral cavernous hemangioma of the middle fossa.

Two cases of extracerebral cavernous hemangioma in the middle fossa are reported. Cerebral angiography showed a large avascular mass lesion in each case, but the tumors were very vascular at operation. Recovery of vision occurred in one case postoperatively. Diagnosis and treatment of these tumors are discussed.

Adult↗