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Biomedical subjects

M Friedman

Publications and source records attributed to M Friedman.

At least 451 records · Page 25Linked to original sources
PubMed1982

EDTA enhancement of strontium uptake by intact human enamel.

The aim of this research was to study the effect of EDTA on the strontium uptake by intact tooth enamel. EDTA did not significantly affect the strontium uptake in an acid medium of pH 4.5. However, it caused a sharp rise in strontium uptake at pH 6.0. At such a pH, the stability constants of the Ca-EDTA complex are approaching a maximal value, and as a result of it a significant dissolution of the surface enamel, accompanied by a highly effective increase of the contact area for strontium uptake, is taking place. In all the experiments, treatment with strontium solution resulted in a decrease of the solubility and dissolution rate of enamel in an acidic environment. The resistance of enamel to acid attack was proportional to the quantity of absorbed strontium, reaching maximal values after treatment with strontium solutions in 10(-2) M EDTA at pH 6.0.

Dental Enamel↗
PubMed1982

Feasibility of altering type A behavior pattern after myocardial infarction. Recurrent Coronary Prevention Project Study: methods, baseline results and preliminary findings.

We studied 1035 consecutive postinfarction patients to determine the feasibility of altering type A behavior and the effect such alteration might have on subsequent rates of infarction and cardiovascular death. Approximately 300 subjects were enrolled in small groups and primarily received cardiologic counseling on the usually accepted coronary risk factors. Six hundred subjects received, in addition to cardiologic counseling, advice and instructions designed to diminish the intensity of their type A behavior. The remaining subjects, serving as controls, received no counseling, but were examined and interviewed annually, as were those who dropped out of counseling groups. More than 98% of the 1035 subjects exhibited moderate-to-severe type A behavior during a videotaped structured interview. After the first year of this 5-year study, the rates of infarction and cardiovascular death were lower (p less than 0.01 and p less than 0.05, respectively) among subjects who received both cardiologic and behavioral counseling than among the control subjects. The rate of nonfatal infarction was lower (p less than 0.05) among subjects who received behavioral counseling than among those who received only cardiologic counseling or those who dropped out of either counseling group. The circumstances that most often preceded recurrent infarction or cardiovascular death were emotional crisis, excess physical activity, ingestion of a single fatty meal or a combination of these phenomena.

Adult↗
PubMed1982

Detection of virus-specific IgA antibodies in serum of kidney transplant patients with recurrent cytomegalovirus infection by enzymeimmuno and radioimmunoassay techniques.

The feasibility of using human cytomegalovirus (CMV)-specific IgA antibody determinations as a signal for early detection of recurrent CMV infections in eight renal transplant recipients was analyzed. Solid phase radioimmunoassay (RIA), enzyme-liked immunosorbent assay (ELISA) and immunoperoxidase assay (IPA) techniques were used for IgA antibody determinations. In parallel, IgG antibodies to CMV were studied by immunoperoxidase assay. A significant rise of CMV-specific IgG antibody titre was observed in all of these patients between 5 and 53 weeks post-transplantation. CMV-specific IgA antibody production was detected close to the time a rise in CMV IgG antibody was observed in seven out of eight patients studied by RIA and ELISA, and in six out of eight patients studied by IPA. In two patients specific CMV IgA antibodies were detected by all three methods before a significant rise of CMV IgG antibody titre was demonstrated. In these patients CMV IgA was detected by RIA earlier than by ELISA and IPA. The potential application of CMV-specific IgA antibody determination for early detection of recurrent CMV infection in renal transplant patients is discussed.

Adult↗
PubMed1982

The recurrent coronary prevention project: initial findings.

A behavioural treatment programme, designed to modify type A behaviour, has been compared with cardiological measures (e.g. diet, exercise and adherence to medication), and with 'no treatment', for its ability to prevent reinfarction in patients who had suffered a myocardial infarct at least six months previously. Provisional results show fewer reinfarctions and greater modification of type A behaviour in the group receiving behavioural treatment. In the third year, to date, the difference favouring behavioural over cardiological measures was statistically significant (P less than 0.01), and other factors seem unlikely to be responsible. The five-year study still has two years to run.

Behavior↗
PubMed1981

Thyroid abnormalities associated with treatment of malignant lymphoma.

The effects on the thyroid of radiation therapy to the neck and/or chemotherapy were investigated in 54 Hodgkin's and 72 non-Hodgkin's lymphoma patients. These patients had received radiation therapy with doses ranging from 2000 to 4000 rad (median 3600 rad) to the cervical or mantle fields and/or multiple-agent chemotherapy following usual staging procedures. Palpable abnormalities of the thyroid were found in 15 patients. The patients with irradiation to the neck had a higher incidence of hypothyroidism than those patients treated with chemotherapy alone (31/74 vs. 8/52, P less than 0.001 for TSH and 10/74 vs. 1/52, P less than 0.025 for T4). A higher frequency of elevated serum TSH levels and antithyroid antibodies were also observed in patients receiving radiation therapy alone to the neck than in those receiving both radiation therapy and chemotherapy (19/33 vs. 12/41, P less than 0.025 for TSH and 16/33 vs. 7/41, p less than 0.01 for antibodies), suggesting that chemotherapy agents may reduce the thyroid dysfunction induced by irradiation. There was no difference in prevalence of elevated TSH levels following irradiation to the neck between patients in whom lymphangiogram was or was not performed (21/51 vs. 10/23).

Adult↗
PubMed1981

Stomal recurrence. A critical analysis of risk factors.

Stomal recurrence developed in 5% of the 507 patients who underwent total laryngectomy for a squamous cell carcinoma. The most common site of the primary tumor was the glottis, followed by the supraglottic and pyriform sinus regions. Initial subglottic extension of the tumor and metastatic lymphadenopathy were the most significant risk factors. The primary tumor size, prior emergency tracheostomy, and conservation surgical procedures had no effect on the incidence of stomal recurrence. The median survival in patients with stomal malignant neoplasms was only five months. In high-risk patients, extended dissection or elective postoperative radiotherapy is recommended.

Carcinoma, Squamous Cell↗
PubMed1981

Bioavailability of some lysine derivatives in mice.

Growth assays using mice on synthetic amino acid diets showed that substituting epsilon-N-methyl-L-lysine, epsilon-N-dimethyl-L-lysine and epsilon-N-trimethyl-L-lysine for lysine resulted in relative replacement values about 1/12, 1/20 and 1/25, respectively, of that obtained with the standard lysine diet. Similar studies showed that the alpha-N-acetyl-L-lysine is not utilized by mice and that the relative the replacement value of epsilon-N-acetyl-L-lysine was about 3% of that of lysine. Analogous substitution of D-lysine and the lysine sulfur-containing analog, S-(2-aminoethyl)-L-cysteine, for lysine resulted in weight losses during the feeding period. The results are discussed with reference to factors that are expected to influence the biological utilization f lysine analogs and derivatives.

Animals↗
PubMed1981

Forced oscillatory resistance and compliance parameters following pneumonectomy in beagle dogs.

Forced oscillatory resistance (RFO) and compliance (CFO) were measured in 3 groups of adult beagle dogs. Group I (n = 12) had undergone a left pneumonectomy at 6-10 weeks of age; group II (n = 11) underwent a similar procedure at 1 year of age; and group III (n = 8) served as unoperated controls. The mean value of RFO for group II was significantly higher than corresponding values for groups I and III. Similarly, the mean value of CFO was significantly lower for group II. Mean values for RFO and CFO between groups I and III were not statistically different. When RFO and CFO were normalized by functional residual capacity, mean values for all three groups were similar. However, when RFO and CFO were normalized by body weight, mean values for groups I and II were significantly different from those of group III. These findings cannot be explained directly by postoperative hyperinflation of the remaining lung. They suggest that there is an adaptive change in the mechanical characteristics of the remaining lung following pneumonectomy and that the degree of adaptation varies with the age of the animal undergoing resection.

Adaptation, Physiological↗
PubMed1981

Léri's pleonosteosis.

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Age Determination by Skeleton↗