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Biomedical subjects

M Frey

Publications and source records attributed to M Frey.

At least 253 records · Page 14Linked to original sources
PubMed1980

[Kleinert's primary flexor tendon repair in children (author's transl)].

The essential points of the Kleinert technique of primary suture of the flexor tendons are briefly laid out. Even although the success of this method depends especially on the co-operation of the patient, we have been able to obtain very good results, particularly in children. Here, too, we used dynamic splinting in the form of a whole-arm splint, and in the case of very small children, the mother was instructed in the therapy.

Child↗
PubMed1980

[Approach to digital replantation in childhood (author's transl)].

Replantation and revascularisation of amputated parts in children is demonstrated in relation to 6 and 8 cases respectively. The indications are discussed. Contra-indications are limited to a poor general condition as a result of multiple trauma or to severe destruction of the amputated part. The organisation of a replantation service id discussed briefly.

Adolescent↗
PubMed1979

[Reconstruction of the breast after surgery for cancer (author's transl)].

The tendency towards less radical, stage-dependent procedures in the surgical management of breast cancer has opened the way to improvement in the reconstructive measures available. Reconstruction of the female breast can be undertaken with greater or lesser success and facility according to whether the initial procedure was subcutaneous mastectomy, modified radical mastectomy or the Rotter--Halstedt radical operation. The different plastic reconstructive methods developed over the past years are discussed and illustrated by cases treated under our care.

Breast↗
PubMed1979

[Functional outcome after reimplantations in the hand and finger region].

Successful replantation of total amputated parts of the hand having been performed during a period of five years were investigated as a homogenous group. Long-term function of replanted parts was evaluated by objective criteria, as signs of use, trophique, vascularisation, mobility, sensibility and the integration of replants into general function of the hand, and on the other side by subjective criteria as usefulness in professional and private life, retrospective personal attitude to replantation and subjective complaints.

Adolescent↗
PubMed1979

[Trophic significance of sensory innervation of the skeletal muscles--an experimental study on the m. sternomastoideus of the rat].

In this study the morphological changes of the sternomastoid muscle of the rat caused respectively by division of sensory afferents, the motor efferents and by total denervation of the muscle are investigated one, two, three and four months after surgery using sections from the middle part of the muscle stained by Sudan-Black-B, Succinodehydrogenase- and ATP-ase-reagent. Small quantitative changes, as shown in curves of distribution of the sizes of muscle fibers, and a remarkable increase in the density of mitochondria in the middle sized muscle fibers after division of the sensory fibres are reported and discussed.

Afferent Pathways↗
PubMed1978

[When to discharge a patient after myocardial infarct].

The evidence suggest that its possible on the fourth day after myocardial infarction to identify a group of patients with near-zero mortality during the next 14 days. These patients can leave hospital on the fifth day if adequate home care is available. Since 66 of our series of 255 patients belonged to this fortunate group, a notable cost reduction was achieved.

Aged↗
PubMed1978

[Results of operative treatment of artial septal defect in the adult (author's transl)].

55 of 59 patients with artial septal defect, who had been operated in adult age, were examined postoperatively. The mean time interval from the operation was 43,8 months. Two patients had died immediately after the operation; there were no late deaths. The majority of the reexamined subjects was free of symptoms, in no case was there congestive heart failure. Persistence of postoperative symptoms increased with increasing age at the time of operation, but only up to the fourth decade of life. In 26 cases hemodynamics were examined. Mean pulmonary arterial pressure was normal at rest and during a slight ergometric load. In 5 patients there was moderate pulmonary hypertension. In 8 subjects there was minimal, in one patient moderate increase of pulmonary vascular resistance. Heartsize in chest roentgenogramm was increased in about 25% of cases, in more than 50% the pulmonary vessels were accentuated. Irregularities of cardiac rhythm were not more frequent postoperatively, than they had been prior to surgery. However, surgery was followed by a marked decrease of right axis deviation and of EKG signs of right ventricular hypertrophy. Pulmonary function studies revealed a slight decrease of vital capacity and of maximal breathing capacity. These results are favourable compaired to medically treated groups of patients as described in the literature. It is concluded, that even in later adult age the atrial septal defect as a rule is an indication for surgery.

Adult↗
PubMed1977

[Mechanism of the cardioprotective effect of triamterene in the rat heart. Myocardial protection via elevation of extracellular K+ and Mg++ concentrations].

1. 2,4,7-Triamino-6-phenyl-pteridine (triamterene) protects the rat heart against isoproterenol-induced myocardial lesions: Whilst cardiotoxic doses of isoproterenol produce deleterious myocardial Ca overload, simultaneous admistration of triamterene diminishes myocardial Ca incorporation considerably. 2. As to the mechanism of action, triamterene increases the plasma contents of K and Mg by inhibiting renal excretion. Accordingly, oral administration of K and Mg salts, leading to a similar rise in the K and Mg concentrations of the plasma, also prevents abundant myocardial Ca incorporation. 3. Cardioprotection by triamterene can, in fact, be simply explained by its action on the plasma K and (particularly) Mg levels. This conclusion is drawn from a quantitative comparison of the inhibitory effects of triamterene (40 mg/kg s.c.) with those of KCl or MgCl2 (10 mMol/kg p.o.) on the isoproterenol-induced increase in myocardial 45Ca uptake and absolute Ca concentration. 4. Isoproterenol induced cardiomyopathy of the rat, an experimental model of non-coronarogenic myocardial lesions, has hitherto been successfully prevented with the use of Ca-antagonists (verapamil, D 600, prenylamine, fendiline). These compounds reduce Ca influx by restricting the Ca conductivity of the myocardial sarcolemma membrane ("slow channel"). The action of triamterene, on the other hand, is based on a totally different cardioprotective principle, namely competitive inhibition of intracellular myocardial Ca accumulation via an increase in K and Mg supply. In the future treatment of cardiomyopathy it seems rather promising to try a combination of both a Ca-antagonist and triamterene, thus applying two different therapeutic principles simultaneously.

Animals↗
PubMed1976

Stability characteristics of freeze-dried human live virus vaccines.

Freeze-drying (lyophilization) of biologically active materials such as human live virus vaccines is an accepted method of preserving potency. Since freeze-drying does not assure total stability, a formal system of monitoring stability, i.e., potency, has been established. Two experimental desings are utilized: (1) Long term studies to duplicate normal use storage at -20 degrees C and 2-8 degrees C and (2) Accelerated studies which predict long term stability through regression analysis using the Arrhenius equation. Data summarizing stability experience over a long period of study will be presented.

Drug Stability↗