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Biomedical subjects

M Flanagan

Publications and source records attributed to M Flanagan.

At least 91 records · Page 5Linked to original sources
PubMed1978

Isoantigens A, B and H in urinary bladder carcinomas following radiotherapy.

ABH tissue isoantigens were measured by the Specific Red Cell Adherence (SRCA) test in 66 surgical specimens of urinary bladder, including 53 transitional cell carcinomas, 2 squamous cell carcinomas and 11 controls. The SRCA test was strongly positive in 10 of 11 controls. ABH isoantigens were absent or equivocally present in 68 percent of noninvasive carcinomas (stage 0) and in 65 percent of invasive carcinomas. Clinical histories revealed that all patients with invasive carcinoma who had strongly positive SRCA test results had received prior radiotherapy to the bladder region. None of the patients with invasive bladder carcinoma with negative or weakly positive SRCA tests had been radiated. Histopathology of tumors in both groups was similar. Results of this retrospective study support the hypothesis that radiation may induce differentiation in tumors, possibly through an enhancement of Golgi apparatus function. The SRCA test should not be used as a predictor of the biological behavior of future recurrences in patients with bladder carcinoma who have received therapeutic radiation since radiation may produce "false positive" SRCA test results.

ABO Blood-Group System↗
PubMed1978

Cellular immunity in bladder cancer patients.

The leukocyte adherence inhibition test was used to evaluate the cellular immune status of 16 patients with a histological diagnosis of transitional cell carcinoma of the bladder. The reactivity of the leukocytes was measured against extracts of transitional cell carcinoma as well as renal cell carcinoma. The leukocytes of age and sex-matched control subjects, as well as patients with urinary tract infection, also were studied. The leukocytes of patients with transitional cell carcinoma were more reactive to extracts of transitional cell carcinoma. These results suggest that a response to tumor-associated antigens is present in transitional cell carcinoma patients.

Adenocarcinoma↗
PubMed1976

A pathological and bacteriological study of the mammary glands of beef cows in north Queensland.

Pathological and bacteriological studies were made of a total of 507 udders from slaughtered beef cows originating from various locations in northern Queensland. Incidence of supernumerary tests was 28%, their distribution being caudal (80%), intercalary (8%), ramal (5%) and anterior 1%; 6% had both caudal and intercalary teats. They were seen most frequency in British breed and British-Brahman crossbreds (each 29%) and less frequently in Brahmans (22%). Gross lesions were found in 11.4% of cows; these lesions comprised cysts (2.8%), leech infestation (1.0%), mastitis (0.6%), teat occlusionsion (3.9%), papillomatosis (1.2%), cutaneous horns (0.4%), teat fistulas (0.4%), teat trauma (0.6%) and udder fibrosis (0.6%). Mastitis was obviously low in occurrence, while leech infestation and teat occlusion were relatively frequent in cows from one area. Bacteriological examination of single quarters in 364 cows, revealed infection in 154 (42.3%). A total of 199 isolations were made of which 3.5% were recognised mastitis pathogens. Pathological conditions were found, and bacterial isolations were made more frequently in aged than in mature or young cows.

Animals↗
PubMedDate not supplied

Stenosis at the origin of an anomalous left main coronary artery arising from the pulmonary artery in a symptom-free adolescent girl: transesophageal echocardiographic findings.

We report an unusual finding of ostial stenosis of an anomalous left main coronary artery originating from the pulmonary artery in a symptom-free adolescent girl. Transesophageal echocardiography with Doppler color imaging correctly identified all of the salient features of this anomaly including proximal stenoses of the right and left coronary arteries. These findings were subsequently confirmed at cardiac catheterization.

Adolescent↗
PubMedDate not supplied

The role of the clinical nurse specialist in tissue viability.

The development of tissue viability clinical nurse specialists in the UK has occurred rapidly and haphazardly over the last decade. Lack of role definition has created ambiguity and additional demands which are not so apparent within more established specialist nurse roles. Many specialist nurses in tissue viability are currently practising without adequate supervision frameworks which may compromise both personal and professional role satisfaction. Evaluation of the specific contribution of tissue viability specialist nurses is problematic for a variety of reasons. These, together with the identification of those factors thought to contribute to role conflict, will be discussed.

Burnout, Professional↗
PubMedDate not supplied

A practical framework for wound assessment. 1: Physiology.

Wound assessment offers practitioners a framework upon which to base clinical decisions aimed at maximizing healing potential. It relies heavily on basic observational skills to detect often subtle differences between a healing and non-healing wound and focuses on the difficulties in identifying clinical signs of wound infection. Part one of this paper relates the physiological process of healing to the practical skill of wound assessment so that appropriate management objectives can be implemented and evaluated. In the second part, wound classification models are reviewed, together with practical methods of wound measurement and suggestions for improving the quality of wound management documentation.

Clinical Competence↗
PubMedDate not supplied

A practical framework for wound assessment. 2: Methods.

Accurate measurement and documentation of wound healing are essential if practitioners are to effectively evaluate the benefits of various treatment approaches. Increasingly, sophisticated wound measurement techniques are evolving, but many are impractical and costly. The physiology of healing and the relationship of each stage of this delicate process to the complex task of wound assessment were reviewed in part one of this article (Vol 5 (22): 1391-7) to help improve practitioners' clinical assessment skills. Part two will discuss ways in which the accuracy of simple, non-invasive measurement approaches may be improved so that overall alterations in wound dimension can be effectively monitored.

Humans↗
PubMedDate not supplied

The impact of change on the tissue viability nurse specialist: 1.

Tissue viability nurse specialists in the UK have experienced difficulty in articulating their role, and this has led to a poor understanding of what they do. This article, the first of two parts, presents a literature review which examines the development of specialism in nursing and explores the factors that have influenced the development of tissue viability specialist nurses in the UK. The study described in the second part of the article uses focus group methodology to examine the practices and experiences of tissue viability nurses working in a changing healthcare environment.

Humans↗
PubMedDate not supplied

Factors influencing tissue viability nurse specialists in the UK: 2.

The literature review presented in the first part of this article (Vol 7(11): 648-57) revealed a lack of empirical data on specific contextual issues concerning the current practice of tissue viability clinical nurse specialists (CNSs) in the UK. This descriptive study utilizes focus groups to explore the experiences of tissue viability CNSs. It highlights the development of a facilitative style of expert practice within this group of nurse specialists and makes recommendations for successful role implementation. The findings suggest that specialist nurses are evolving a style of practice in congruence with the UKCC's vision of specialist practice (UKCC, 1994) and that these characteristics are likely to become more apparent over the next decade.

Attitude of Health Personnel↗
PubMedDate not supplied

The provision of leg ulcer services by practice nurses.

As part of their implementation programme of leg ulcer guidelines, the group conducted a study of the caseload and attitudes and training of practice nurses with relation to leg ulcer management. They begin by outlining the prevalence and treatment methods of leg ulcers, then outline their study and put forward their resulting recommendations.

Education, Nursing, Continuing↗
PubMedDate not supplied

Outside influences.

Explore the source record for details and available documents.

Adult↗