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Biomedical subjects

M Flanagan

Publications and source records attributed to M Flanagan.

At least 73 records · Page 4Linked to original sources
PubMed1984

Clathrin lattice reorganization: theoretical considerations.

We wish to postulate a mechanism by which flat hexagonal lattices of clathrin trimers transform into coated pits. Using an established model for packing trimers into lattices, we explored the assembly process by single addition of trimers to form polygons. Subject to favorable conditions, removal of a single trimer from a hexagon could lead to the formation of a pentagon. Elimination of trimers from polygonal sheets can occur either at the center of the network or at the edges. Removal of a trimer from the center of these adjacent polygons, "hub transformation," is possible in very few instances, whereas removal from the edges of a polygonal sheet, "fringe transformation," is possible in a host of cases. These hypothetical constructs can be used effectively to explain intermediate structures actually observed in flat hexagonal lattices. The geometry of a purely hexagonal lattice seems to dictate that the first step in transformation must be a "fringe transformation," which then will allow subsequent "hub transformation" to take place leading to the introduction of pentagons into the center of the lattice and ultimately to the curvature of the clathrin lattice.

Biopolymers↗
PubMed1984

Mitomycin C intravesical therapy in noninvasive bladder cancer after failure on thiotepa.

Mitomycin C 40 mg in 40 ml water was administered intravesically every week for 8 consecutive weeks to 60 patients with superficial bladder cancer. All patients had failed treatment with intravesical thiotepa and had evaluable disease. An objective response of 50% or greater reduction in measured tumor mucosal involvement was obtained in 68% of patients. Forty-two percent of the patients achieved a complete response, and this included 50% of patients with Grade III disease and 70% of patients with a T1 tumor. Median response duration in complete responders was 12.2 months with a range of 3.5 to 24.3 + months. Fifty-five percent of patients are still responding. Therapy was generally well tolerated, and in contrast to thiotepa, myelosuppression was not the dose-limiting effect. One third of all patients experienced symptoms of local irritation, and skin reactions were seen in 12% of patients.

Adult↗
PubMed1983

Nifedipine in the treatment of hypertension.

Nifedipine, a calcium antagonist with a predominant vasodilator action, was evaluated for the treatment of hypertension. A 20 mg-tablet, with a slower absorption and a more sustained blood-level than provided by the 10 mg-capsule was administered to 20 patients. The duration of the trial was 20 weeks. All patients achieved a significant reduction in both systolic (p less than 0.05) and diastolic (p less than 0.001) blood-pressure (B.P.), but 10 patients were withdrawn before completion of the trial period. Two patients, although achieving a fall in B.P. which was significant, did not reach to target level (less than 160/90) on maximal dosage, one patient suffered a stroke due to a cerebral infarct, and seven patients were withdrawn because of side-effects due mainly to vasodilatation. The remaining 10 patients obtained a satisfactory response. In nine patients, who had achieved a satisfactory result, there was no change in plasma renin activity (P.R.A.) during chronic nifedipine administration.

Absorption↗
PubMed1983

Aetiology of chronic constrictive pericarditis.

In a consecutive series of 32 cases of chronic constrictive pericarditis treated by pericardiectomy during the past 25 years, four were attributable to rheumatoid disease, two to trauma, one to sarcoidosis, and four, at a maximum, to tuberculosis. In the remaining 21 cases of undetermined aetiology there was no evidence of tuberculosis. It appears, therefore, that tuberculosis was not a common cause of chronic constrictive pericarditis during the period under review, which included the 1950s and early 1960s when tuberculosis was widespread.

Adolescent↗
PubMed1982

Bluetongue virus serotype 20 infection in pregnant Merino sheep.

Eleven maiden Merino ewes, free of antibody to bluetongue virus serotype 20 (BTV-20) in agar gel immunodiffusion and serum neutralisation tests, were mated once with a ram. Ten ewes were inoculated with BTV-20 35 to 42 days after service, and one ewe was left as an uninoculated control. One of the inoculated ewes and the control ewe remained uninfected throughout the experiment. Eight of the remaining 9 ewes showed clinical signs ranging from mild to moderate, and the other showed no clinical signs of infection. BTV-20 viraemia was detected in ewes between days 3 and 11 post inoculation, and the serum antibody response was followed. The control ewe and 5 of the 9 infected ewes were pregnant when examined 90 to 97 days after service. Each of these animals produced a normal lamb. There was no evidence of abortion in the remaining 5 ewes, and no transplacental transfer of virus was detected in the lambs of the 5 infected ewes. At necropsy, 46 days after the birth of the last lamb, no gross or microscopic lesions were observed in either the ewes or lambs.

Animals↗
PubMed1980

Effects of therapy on carcinoembryonic antigen activity in the urines of patients with cancer of the bladder.

Carcino-embryonic antigen (CEA) levels were quantitated in specimens of urine for 16 patients with invasive transitional-cell carcinoma of the urinary bladder. Four of the patients had received x-irradiation to the bladder and four had been treated with the radiomimetic agent, thiotepa. Urinary CEA levels in these patients (3.7 +/- 2.4 ng/ml) were significantly lower (t = 6.17, P less than .001) than levels from a similar group of eight patients who had not been treated with radiotherapy (20.3 +/- 8.7 ng/ml). These results suggest that "false-negative" urinary CEA levels may, in some cases, be associated with previous radiotherapy.

Carcinoembryonic Antigen↗
PubMed1980

Acute central cervical spinal cord syndrome caused by missile injury: case report and brief review of the syndrome.

The authors present the second reported case of acute central cervical spinal cord syndrome caused by a missile injury. A low caliber, low velocity bullet penetrated the spinal cord posteroanteriorly at C-2, C-3 in the midline, producing quadriplegia and respiratory failure. Within 3 months the patient was ambulatory. Because such a good outcome is possible, patients with similar injuries should be supported vigorously. Injury to the central cervical spinal cord seems to produce a constant syndrome irrespective of the specific nature of the primary injury. The literature on this syndrome is briefly reviewed.

Acute Disease↗
PubMed1980

The effects of diet on high density lipoprotein cholesterol.

Twenty-nine patients with normal blood lipids were placed on diets. Thirteen, mainly attending hospital for varicose veins, were prescribed low-energy diets: HDL-cholesterol was raised after one month and significantly after three months (P less than 0.02); total cholesterol was lowered (P less than 0.05). Sixteen patients, mainly with irritable bowel symptoms, were prescribed high-fibre diet: HDL-C was raised after one month (P less than 0.05), but not significantly so after three months; total cholesterol was unchanged.

Adult↗
PubMed1979

Nursing comes of age in South Korea--with an American Maryknoller's help.

Maryknoll Sister Patricia Conroy devoted 20 years to the nursing profession in South Korea. Through her work with the Maryknoll Junior College of Nursing in Busan and with the Korean Nurses Association she was instrumental in changing the traditional, Western-oriented nursing curriculum to a course of study more suited to South Korea's present community health needs.

Catholicism↗