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Biomedical subjects

M Fisher

Publications and source records attributed to M Fisher.

At least 433 records · Page 24Linked to original sources
PubMed1988

Meeting the health care needs of suburban youth: review of a clinical service.

The demographic and medical data from the first 1,000 patients registered at a suburban adolescent health service were reviewed and the findings compared with the results of an initial survey performed in the same community and other health services located in urban communities. Most of the patients were white (92%), girls (82%), and 16 to 18 years of age (63%) and had parents who graduated from high school (59%) or college (28%). They reported higher rates of participation in health-risk behaviors, including smoking (50%), drinking (60%), drug use (67%), and sexual intercourse (83%), than their peers. Seventy-two percent of the patients sought medical attention for sexuality-related or gynecologic concerns, including contraception (39%), pregnancy determination (20%), and evaluation of possible sexually transmitted disease (9%), and 28% sought attention for general medical or emotional needs, including checkups or immunizations (11%), nutritional or weight problems (4%), and emotional issues or substance abuse (4%). Management of sexuality-related issues differed from that reported in urban settings, whereas laboratory screening tests indicated that problems were similar to those in other settings. Many problems described in an initial survey of youth in the community were not seen at the adolescent health service. We conclude that a suburban-based health service may meet certain health care needs of the higher risk youth of the community but that ultimate care for adolescents remains with the private physicians in this setting.

Adolescent↗
PubMed1987

The importance of carotid artery plaque disruption and hemorrhage.

The event or mechanism that causes an asymptomatic atherosclerotic carotid artery to become symptomatic remains uncertain. Analysis of carotid endarterectomy surgical specimens from symptomatic patients has suggested that primary intraplaque hemorrhage is the most important initiating event. Reanalysis of several recent series of carotid endarterectomy specimens demonstrated that plaque disruption (ulceration) occurs as frequently as plaque hemorrhage, and that both processes are significantly more frequent in symptomatic as compared with asymptomatic endarterectomy specimens. A review of the coronary artery pathology literature reveals that plaque disruption is commonly present in patients with acute fatal myocardial infarction. It is widely asserted that coronary artery plaque disruption leads to luminal thrombosis and intraplaque hemorrhage. A similar sequence of events may occur in symptomatic carotid arteries.

Arteriosclerosis↗
PubMed1987

Fetal oxygen extraction: comparison of the human and sheep.

To estimate fetal oxygen extraction in the human, the inverse, linear relationship between umbilical arterial PO2 and oxygen extraction was calculated from measurements made on cord blood samples obtained after vaginal (n = 12) and cesarean (n = 16) delivery and used to predict oxygen extraction in utero. Comparisons with similar data from fetal lambs in utero and during labor and delivery indicate that extraction in the human and sheep fetus is 47% and 27%, respectively, at PaO2 = 20 mm Hg. For the human fetus to have extraction similar to that in the fetal lamb, vascular PO2 would have to be substantially higher. This would lead to a higher umbilical venous oxygen content in the human, compensating for the lower umbilical blood flow and yielding a rate of oxygen delivery comparable with that observed in the fetal sheep. These data indicate that there may be significant quantitative differences in the fetal oxygen delivery systems in the human and sheep.

Animals↗
PubMed1987

Anaphylaxis.

The clinical syndrome of anaphylactic shock is a disorder produced by multiple mechanisms and pharmacological and environmental factors. The syndrome may be produced by both immunologic and nonimmunologic mechanisms and is due to the release of preformed biologically active mediators and the generation of biologically active mediators. The main mediator appears to be histamine. Although there are a number of defined predisposing factors, the majority of first reactions appear unpredictably. The mainstay of treatment is the use of epinephrine, volume replacement, and positive pressure ventilation. The follow-up and documentation of details of the reaction and exhaustive efforts to determine the precipitating factor are important aspects of the subsequent safety of the patient. History may be of more value than diagnostic testing. The use of H1 and H2 blockers, with steroids and sympathomimetics, may reduce the risk or magnitude of reactions in patients with a past history of a reaction.

Anaphylaxis↗
PubMed1987

Short-latency somatosensory evoked potentials correlate with the severity of the neurological deficit and sensory abnormalities following cerebral ischemia.

Short-latency somatosensory evoked potentials (SSEPs) were studied in 49 patients who had suffered hemispheric or thalamic ischemia, including 6 patients with transient ischemic attacks (TIAs) and 3 patients with reversible ischemic neurological deficits (RINDs). SSEPs were abnormal in 30 patients (61%). SSEP abnormalities correlated with the presence of sensory deficit and the degree of neurological deficit. SSEPs were normal following TIA but were abnormal in 2 of 3 patients with RINDs. SSEPs were abnormal in some patients without sensory deficits suggesting that sensory pathways may be affected when clinically inapparent.

Adult↗
PubMed1987

Comparative analysis of the effectiveness of the diaphragm and birth control pill during the first year of use among suburban adolescents.

Little attention has been paid to the diaphragm as a contraceptive option for adolescents. To compare diaphragm and birth control pill use by adolescents, 124 females (aged 13-20 years) in a suburban-based adolescent health service were interviewed at least one year after receiving a contraceptive prescription. The 73 diaphragm choosers did not differ from the 51 pill choosers in age, race, or reason for their original visit to the health service. Diaphragm choosers, however, were better students, of higher socioeconomic status, and had had fewer prior pregnancies. In the year following prescription, continuous use for 12 months was reported by 43% of diaphragm choosers and 45% of pill choosers, with significantly more pill (26%) than diaphragm (8%) choosers reporting discontinued use for at least one month while remaining sexually active. Regular use (diaphragm every intercourse, missing less than or equal to 1 pill/month) was reported by 36% of diaphragm choosers compared to 88% of pill choosers; and at least one pregnancy during the year was reported by 15% of diaphragm choosers and 18% of pill choosers. At follow-up interviews, diaphragm subjects disliked the immediate annoyances of the diaphragm, and pill users expressed concern about the potential side effects of the pill. No single factor or set of factors correlated with continuous and regular use of either method. Because both methods present specific problems for certain patients, we suggest that in addition to the pill, the diaphragm should receive serious consideration as a contraceptive option for adolescents.

Adolescent↗
PubMed1987

Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients.

We found a small but statistically significant reduction in the linoleic acid concentration of white blood cells and platelets in MS patients. The percent linoleic acid concentration (mean +/- S.D.) in the white blood cells if 24 MS patients was 8.8 +/- 1.8% as compared with 11.4 +/- 4.9 in 24 age and sex-matched controls (p less than 0.05). Platelet levels were 8.5 +/- 2.4% and 10.6 +/- 3.8% respectively (P less than 0.05). Serum linoleic acid levels were not significantly different in the two groups. The possible role of linoleic acid in the pathogenesis of MS has yet to be defined.

Adult↗
PubMed1987

Ventilatory dysfunction in palatal myoclonus.

A patient with palatal myoclonus and involvement of respiratory muscles is described. Partial characterization of the mechanism of ventilatory dysfunction was achieved using noninvasive tests. Ventilatory dysfunction in this disorder can be manifested in different patterns depending on which respiratory muscles are involved predominantly.

Electromyography↗
PubMed1987

Variability in arteriographic assessment of the carotid bifurcation.

We evaluated interobserver and intraobserver variability in the arteriographic assessment of the carotid bifurcation. Two neuroradiologists evaluated area stenosis and lumen surface morphology for 60 biplane carotid arteriograms in two reading sessions. Absolute interobserver differences for area stenosis averaged 8.8%, and interobserver differences were statistically significant for arteries of at least 50% stenosis. Analysis of observations for lumen surface morphology revealed statistically significant interobserver differences, averaging 29.5% disagreement. Intraobserver differences were not statistically significant. Observer variability for arteriography should be considered in the process of evaluating patients for carotid endarterectomy.

Carotid Arteries↗
PubMed1987

Patterns of fibrin deposits in carotid artery plaques.

We evaluated 40 consecutive carotid endarterectomy specimens for the presence of fibrin. Intraplaque hemorrhage was noted in 93% of specimens. At the plaque surface, there were two patterns of fibrin distribution. Type I, suggesting a lumen thrombus, was found in 7 specimens. Type II, suggesting an intraplaque hemorrhage at the lumen surface, was found in 15 specimens. These changes were not significantly associated with the presence of ischemic symptoms or the use of antiplatelet or anticoagulant medications. All specimens with Type I change had arteriographic evidence of at least 70% diameter stenosis. The frequent lack of fibrin at the plaque surface suggests that there may be inherent limitations of standard medical treatment for carotid artery disease.

Arteriosclerosis↗
PubMed1987

Brachial neuropathy after brachial artery-antecubital vein shunts for chronic hemodialysis.

Peripheral mononeuropathies may complicate distal arteriovenous fistulas for chronic renal dialysis. We observed three diabetic patients who developed pain, paresthesias, and weakness in the distribution of the median, ulnar, and radial nerves shortly after construction of proximal brachial artery-antecubital vein fistulas. EMG confirmed multiple distal nerve injuries. All three patients improved after shunt banding or ligation. Twenty additional patients with proximal shunts were examined for risk factors for brachial neuropathy. Although all patients had severe atherosclerosis and many had polyneuropathy, we identified no predictive risk factors other than diabetes.

Adult↗
PubMed1987

Maternal factors and low birthweight infants: a comparison of blacks with Mexican-Americans.

Regional vital statistics suggest that the Mexican-American population, in spite of low socioeconomic status, has an infant mortality that is very similar to whites. American blacks of similar socioeconomic status have rates that are almost double that of whites. Part of this discrepancy can be explained by lifestyles, maternal behavior, lack of access to health care, and poor nutrition. The study reported here compared the most potent predictor of infant mortality--low birthweight--among low-income black and Mexican-American infants born at Cook County Hospital. The incidence of low birthweight was 16.6 percent for blacks and 5.9 percent for Mexican-Americans, suggesting that the latter group enjoys some sociocultural protection from the effects of urban poverty in the United States. Further efforts to reduce the infant mortality rate in the inner city should be directed at preserving those sociocultural traits that improve pregnancy outcomes and changing those social and economic factors that cause and promote unhealthy maternal behavior.

Black or African American↗
PubMed1986

Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model.

We studied the effect of cod-liver oil on the development and progression of coronary artery disease in swine subjected to coronary balloon abrasion and fed an atherogenic diet for eight months. Sections from serial 3-mm segments of the coronary arteries were analyzed morphometrically in 7 pigs given a cod-liver-oil supplement and 11 control animals not given the supplement. Significantly less disease was seen in the sections from the animals fed cod-liver oil. The mean lesion area per vessel, mean luminal encroachment per vessel, and mean maximal luminal encroachment per vessel were reduced in animals fed cod-liver oil, as compared with controls, (P = 0.05, P = 0.016, and P = 0.011, respectively). Both groups of animals had severe hyperlipidemia throughout the study. Differences in the extent of coronary atherosclerosis were not related to differences in plasma lipid levels. Platelet arachidonate was markedly reduced, platelet eicosapentaenoic acid was increased, and serum thromboxane was decreased in the oil-fed group as compared with the control group. We conclude that in our animal mode, dietary cod-liver oil retarded the development of coronary artery disease, possibly through changes in prostaglandin metabolism.

Animals↗