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Biomedical subjects

M Finzi

Publications and source records attributed to M Finzi.

At least 19 recordsLinked to original sources

Hepatocellular carcinoma: comparison between liver transplantation, resective surgery, ethanol injection, and chemoembolization.

Between January 1989 and June 1997, 533 patients (423 male, 110 female, mean age 61 years, range 22-89 years) with hepatocellular carcinoma (HCC) were observed at our center. We report on 419 patients retrospectively compared for different treatments: liver transplantation (LT; 55 patients), resective surgery (RS; 41 patients), transarterial chemoembolization (TACE; 171 patients) and percutaneous ethanol injection (PEI; 152 patients). The 3- and 5-year actuarial survival rates were, respectively, 72% and 68% for LT, 64 and 44% for RS, 54 and 36% for PEI, and 32 and 22% for TACE. Survival curves were compared for sex, age, tumor characteristics, alphafetoprotein level, Child class, and etiology of cirrhosis. All patient-related characteristics examined (sex, age) are not significantly related to patient survival. Tumor-related variables and associated liver disease variables significantly conditioned survival in relation to different treatments. LT seems to be the treatment of choice for monofocal HCC less then 5 cm in diameter and in selected cases of plurifocal HCC.

Actuarial Analysis

[Tibio-fibular graft as a treatment of non-union of the tibia (author's transl)].

The authors have reviewed 47 cases of septic non-union of the tibia treated by tibio-fibular graft, Bone union was obtained in 31 cases, 2 limbs were amputated and 13 tibiae were united after another procedure. In 17 cases the grafts were performed in the presence of a discharging sinus. These cases did as well as any others. In cases of bone loss after diaphyseal resection, tibio-fibular grafting appeared to be a better procedure than Papineau's technique. Several cases of failure of this technique were cured successfully by tibio-fibular grafting when the bone loss was extensive, tibio-fibular grafting had to be completed by a supplementary tibial graft. The authors consider that grafting procedure should be done early in cases of extensive bone loss or in cases of severe compound comminuted fracture.

Adult

Prevalence of hepatitis B markers (HBsAg and HBsAb) in women screened at time of delivery.

Two thousand women were screened at the time of delivery for two hepatitis B markers, surface antigen (HBsAg) and antibody (HBsAb), in order to determine prevalence rates, define high-risk groups and estimate the cost-efficiency of routine screening. It was found that 2.2% of the women were HBsAg positive and 32% of a 20% subsample were HBsAb positive. Jewish women of North African origin had the highest rates (HBsAg, 3.8%; HBsAb, 47%) and those of European origin had the lowest (1.2 and 14%, respectively). Bedouin women had intermediate rates (HBsAg, 1.1%; HBsAb, 28%). The issue of screening pregnant women for HBsAg is discussed in light of these results.

Adolescent

[Assay of antithrombin III and soluble fibrin complexes in the study of blood thrombophilia (author's transl)].

The authors conducted a series of experiments concerning the condition of hypercoagulability of patients with a history of thrombosis, in view of determining whether or not the risk of thrombosis could be assessed by laboratory tests. To that end they assayed antithrombin iii activity and soluble fibrin complexes in their test subjects. Antithrombin activity was assayed by a chromogenic method; soluble fibrin complexes by the hemoagglutination test. The activity of antithrombon III was significantly reduced in patients with venous thrombosis, not so in arterial thrombosis. Testing for soluble fibrin complexes was invariably unrewarding, probably because the thrombosis episodes under investigation were of too long standing.

Adolescent

[Rational diet].

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Dietary Carbohydrates