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Biomedical subjects

M Ferrari

Publications and source records attributed to M Ferrari.

At least 721 records · Page 40Linked to original sources
PubMed1977

Plasma digoxin concentrations in patients with atrial fibrillation and indications for the association with other antiarrhythmic agents.

The influence of practolol or verapamil on the activity of digoxin in atrial fibrillation has been studied in 16 hospitalized patients by determining plasma levels of the cardiac glycoside and its effects on the ventricular rate, before and during the association with each of the above drugs. Digoxin alone (0.25 mg/day p.o.) demonstrated a rather feeble activity, giving a satisfactory control of ventricular rate in only 3 patients. The association with low doses of practolol (50 or 100 mg twice a day p.o.) or with verapamil (80 mg three times a day p.o.) clearly improves the effects of digoxin. The action both of practolol and of verapamil is related to the pre-existing ventricular rate, the tachycardic patients being the most sensitive ones.

Aged↗
PubMed1975

[Effects of verapamil on the electrical and mechanical activity of smooth muscle].

Verapamil inhibited both the electrical and the mechanical activity of isolated guinea-pig taenia coli. The action of the drug was similar in some respects to that of quinidine as far as the electrical activity was concerned. Closer similarities were observed between it and diphenylhydantoin. The conclusion is drawn that the drug has points of attack at the electromechanical junction and the membrane.

Action Potentials↗
PubMed1975

Effects of quinidine and diphenylhydantoin on membrane resistance in smooth muscle.

The effects of quinidine and diphenylhydantoin on the membrane electrical resistance of guinea-pig taenia coli have been studied by means of the double sucrose gap tachnique. At concentrations ranging from 2 to 7.10-minus 5 quinidine induces an evident dose-related increase of membrane resistance, as indicated by the increase of the electrotonic potential. These effects are unaffected by tetrodotoxin (10(-6)) and in the presence of various changes of ionic environment (replacement of Na by Li, increase of K or Ca or Mg concentrations). Only a concomitant rise of both K and Ca (or Mg) can prevent the effects of quinidine on membrane resistance. The rate of repetitive discharge under sustained electrical depolarization is not affected by quinidine, at concentrations increasing membrane resistance. The experiments with diphenylhydantoin showed that this drug is practically ineffective on membrane resistance, but induces a decrease of the rate of repetitive discharge under sustained depolarization.

Animals↗