Search PubMed⌕ Search

Biomedical subjects

M Ferrari

Publications and source records attributed to M Ferrari.

At least 703 records · Page 39Linked to original sources
PubMed1979

[Incidence of thyroid diseases in primary hyperparathyroidism].

The incidence of thyroid diseases was evaluated in patients with primary hyperparathyroidism subjected to parathyroidectomy. Eleven patients (26.8%) were affected in this way: 2 with carcinoma, 5 with nodular goitre, and 4 with adenoma. The possible reasons for associations of this kind are discussed, and it is suggested that their high frequency points to a relationship of cause and affect.

Adenoma↗
PubMed1979

18Q - syndrome resulting from a tdic(14p; 18q).

A case of 18q- syndrome due to a de novo tdic(14p;18q) is presented. The interest of this observation lies in the rarity of stable dicentric chromosomes arising from reciprocal translocations between autosomes.

Abnormalities, Multiple↗
PubMed1979

Metabolic changes in red blood cells in malignant lymphomas.

Serum copper levels (SCL) which are concomitantly related to red blood cell free copper are significantly increased in some malignant lymphomas in the phase of activity. This results in a profound inhibition of red cell key glycolytic enzymes, hexokinase (Hx) being the most sensitive. Fifteen patients (eight with Hodgkin's disease and seven with non-Hodgkin's lymphoma) were studied for serum and red cell copper concentrations and Hx activity. The mean red cell life span was determined using 51Cr labelled red cells. The resulting data shows that in active disease an increase in SCL was associated with a decrease in Hx activity and a shortened red cell survival. In these cases there was no evidence of autoimmune phenomena or of direct bone marrow involvement by the disease. It is suggested that the increase in copper levels results in a shortened red cell life span through a copper-induced inhibition of red cell Hx.

Copper↗
PubMed1979

A collagen film for microdetermination of collagenase activity.

A simple, rapid, sensitive, and specific film assay for collagenase activity employing a glass-supported, reconstituted collagen gel is described. Digestion of the collagen film results in sharply defined zones of lysis detectable by staining with Coomassie blue. The assay is semiquantitative and suitable for micro enzyme determination in biological fluids.

Microbial Collagenase↗
PubMed1979

[Creatinine clearance: indirect estimate (author's transl)].

The validity of some formulas proposed to estimate the creatunine clearance by values of serum creatinine and others non analytical parameters (sex, age, weight and height) was tested in a group of 200 adults (100 males and 100 females) and in a group of 134 children (80 males and 54 females). The age ranged from 1 month to 78 years; the values of serum creatinine varied from 0.3 to 10.0 mg/dl; the clearance value was calculated also in the usual way by the AutoAnalyzer (N-11 a Technicon method). The statistical analysis and the comparison of the data show good correlation between the clearance values calculated either by the direct or the indirect method. However the frequency of inacceptable disagreements does not allow the use of these formulas to evaluate the renal function and to regulate the administration of some drugs.

Adult↗
PubMed1978

Discriminant analysis in the differential diagnosis of hypercalcaemia.

Linear discriminant analysis, a multivariate statistical procedure, applied to serum calcium, phosphate, alkaline phosphatase, bicarbonate, chloride, creatinine and tubular reabsorption of phosphate, proved to be effective in distinguishing patients with Primary Hyperparathyroidism from other hypercalcaemic patients in eithy-four retrospective cases. The application of the model to thirty-four prospective cases enabled us to separate correctly, hyperparathyroid patients from non-parathyroid hypercalcaemic patients.

Diagnosis, Differential↗
PubMed1978

[Partial trisomy 13 (13q14 leads to 13qter) in mosaic (author's transl)].

A case of partial trisomy 13 with mosaicism in a 6 1/2 year-old boy is reported. Concerning this case and according to previous data in the literature, the authors try to give a precise topology for trisomy 13; it is possible to outline phenotypes specific for a trisomy of both the proximal third and the distal two thirds of the chromosome, but it appears difficult to suggest a more precise picture for the topology of trisomy 13. This difficulty is related to the notion of phenotypic variability encountered in complete trisomy 13.

Abnormalities, Multiple↗
PubMed1978

[Current problems in diagnosis and screening of thalassemia (author's transl)].

The diagnosis of different forms of thalassemia, considering the genetic variant giving different hematological pattern, is discussed. The laboratory tests useful for this diagnosis and mainly the most recent techniques are particularly considered for their specificity and convenience. The problems of screening with special consideration for health education, laboratory tests and different social and psychological aspects are treated.

Anemia, Hypochromic↗
PubMed1977

Prognostic significance of radiological bone involvement in childhood acute lymphoblastic leukaemia.

In 98 children with acute lymphoblastic leukaemia, aged 1 to 12 years, the prognostic significance of radiological bone involvement was studied. The mean duration of remission and of survival was much shorter in cases with multiple bone involvement (3 or more bones) than in those where bone involvement was absent. In those cases presenting with 1 or 2 bone lesions no statement of prognostic significance can be made at this stage. A radiological skeletal survey should be made in all children presenting with leukaemia to identify those (about 15%) having multiple bone lesions and therefore a poor prognosis, in order that they can be given more intensive therapy.

Bone Neoplasms↗