Biomedical subjects

M Fabri

Publications and source records attributed to M Fabri.

58 records · Page 4Linked to original sources

PubMedDate not supplied

[Epstein-Barr, hepatitis B and hepatitis C virus infections and their oncogenic potentials].

There are two ways of connecting Epstein-Barr virus (EBV) with the uncontrolled growth of EBV infected B lymphocytes: in case of evident immunosuppression when the control by cellular immunity is missing or in the case of pathological growth of malignant clone as a result of genetic translocations. Today, EBV is linked with the development of lymphomas in immunosuppressed patients, Hodgkin's and Burkitt's lymphoma and nasopharyngeal carcinoma. The presence of EBV genome in these patients can be confirmed in malignant cells, in lower or higher percent, as well as the high titers of antibodies against specific virus antigens. Hepatitis B viral infection (HBVI) of specific chronic course and associated with intensified inflammation and mitotic activity is of one of the most important factors in the appearance of hepatocellular carcinoma. Although the integration of viral DNA in DNA of hepatocytes has been one of the possible preconditions for carcinogenesis, recently a great attention has been paid to the inactivation of p53 suppressor gene, being a transcriptive transactivator. Other possible cofactors of carcinogenesis imply long-lasting viral replication, coinfection with HVB, HCV or HDV, interaction with other chemical carcinogens (hormones, aflatoxin, alcohol and similar). In distinction from other human DNA viruses, Hepatitis C virus (HCV) is a RNA virus which is not integrated in genome of hepatocyte and active replication of virus is maintained even when hepatocellular carcinoma is detected. It has been assumed that HCV inactivate or mutate the gene of tumor suppression p53 in an early stage of hepatocellular carcinoma development.

Carcinoma, Hepatocellular↗

PubMedDate not supplied

[Coronary and carotid occlusive disease--surgical techniques and results].

In the period 1982-1996, 7,476 aortocoronary bypass surgeries were performed at the University Clinic for Cardiovascular Surgery in Novi Sad with perioperative mortality of 2.85%. In 242 patients (3.24%) an additional thrombendarterectomy procedure of carotid arteries was performed with indications such as: positive neurologic symptoms; critical morphology of carotid lesions according to Wesley-Moore symptomatology and critical stenosis. The cardiac status of patients was as follows: poor left ventricular function (EF--ejection fraction--30%) in 42 patients (19.2%), left main coronary artery stenosis in 31 patients (12.8%), endarterectomy of coronary arteries due to diffuse and distal coronary occlusive disease in 93 patients (38.5%) and isolated aortocoronary bypass in 149 patients (61.8%). The status of carotid arteries was as follows: unilateral stenosis in 156 patients and bilateral stenosis in 63. Depending on the carotid or cardiac finding, our surgical strategies differed: 65 patients (26.8%) underwent simultaneous operation, 141 patients (58.2%) underwent two-stage operation and in 36 patients (14.9%) three-stage operation was performed. Postoperative complications included: neurological deficit in 4 patients (1.7%); Transient ischemic attacks in 5 patients (2.1%); myocardial infarction in 6 patients (2.7%); hemorrhage in 2 patients (0.9%); gastrointestinal hemorrhage in 3 patients (1.4%); pulmonary complications in 2 patients (0.9%); serious rhythmic disorders in 1 patient (0.5%) and therapeutically resistant hypertension in 1 patient (0.5%). Ten patients (4.1%) died. Causes of death: cardiac in 3 patients (1.4%), neurological in 3 patients (1.4%), pulmonary embolism in 1 patient (0.5%) and other causes in 3 patients (1.4%). The operative risk in this group of polyvascular patients is higher than in the "group with isolated aortocoronary disease". Appropriate indications for surgery in one, two or three stages significantly decrease mortality in these patients. Simultaneous operation is reserved for patients with severe neurological symptoms and unstable angina.

Aged↗

PubMedDate not supplied

[Interferon alpha in the treatment of prolonged hepatitis A virus infection].

Hepatitis A viral infection usually lasts up to 12 weeks, but in 3-16% of patients relapses may occur and the course of the disease is protracted. The outcome of hepatitis A is always good, so that antiviral therapy is not necessary. However, from the aspect of patients with protracted course of the disease up to a year, it might be important to restore clinical recovery in a shorter period of time. Knowing about antiviral and immunomodulatory effects of endogenous interferon (virally activated) in treatment of protracted hepatitis A, we introduced interferon-alpha in the 12th week of the disease and followed-up its effects on the further course of the disease. The study comprised 80 patients with established diagnosis of acute protracted hepatitis A, excluding hepatitis B, Epstein-Barr, cytomegalovirus, adenovirus or toxic liver lesion. In 40 patients treated with interferon we followed up the activity of aminotransferases and persistence of IgM-anti-HAV in correlation with the same parameters in 40 patients treated symptomatically. The registered persistence of aminotransferases' pathological activity was 20:30 weeks (interferon: symptomatic therapy). In greater doses interferon affected the length of persistence IgM-anti-HAV, 20:34 weeks (interferon: symptomatic therapy).

Antiviral Agents↗

PubMedDate not supplied

[Peripheral neurologic complications after carotid surgery].

INTRODUCTION: In recent years, with development of carotid surgery and significant decrease of central neurological complications, more and more attention has been paid to the occurrence of peripheral neurological complications. Most frequent neurological lesions are as follows: auricularis magnus nerve, hypoglossal nerve, vagal nerve, inf. laryngeal nerve, sup. laryngeal nerve, glossopharyngeal nerve and spinal nerve. MATERIAL AND METHODS: In the period from May 1995 to January 1997, 97 patients underwent surgery because of carotid arteries lesions. Bilateral lesion of carotid arteries was treated in 27 patients. Standardized surgical procedures were performed while neurological examinations were performed postoperatively to check for possible peripheral neurological deficit. RESULTS: Cerebrovascular insult was the cause of death in one patient (1.2%). Transitory ischemic attack also occurred in one patient (1.2%). Peripheral nerve lesions were observed in 13 patients that is in 11.3% of cases; auricularis magnus nerve lesion in 9 patients (8.3%); sup. laryngeal nerve lesion in 3 patients (2.8%); mandibular branch of the facial nerve lesion in one patient (0.9%). DISCUSSION: The global incidence of postoperative peripheral neurological complications after carotid surgery was 11.3% cases, while according to the literature data it is from 10.5% to 13%. The most frequent are the lesions of auricularis magnus nerve and sup. laryngeal nerve. CONCLUSION: The incidence of peripheral neurological complications is higher than it is thought to be. Majority of these lesions are with transitory effect. Good knowledge of the precise surgical technique is a prerequisite to decrease the rate of these complications.

Carotid Arteries↗