[Methodological approaches to the study of parenteral and tube feeding in an experiment].
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Biomedical subjects
Publications and source records attributed to M F Nesterin.
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When 25% RNA to the protein mass was introduced in the ration given to rats, deposition of urates occurred in the kidneys of the animals in the form of microlites of different sizes. These microlites were found in lumina of distal parts of the convoluted tubules and collective tubules at 21 days of the experiment. In addition to RNA, microlites included RNA, neutral and acid mucopolysaccharides, as well as calcium salts. The epithelium of the tubules at sites of microlite localization underwent necrobiotic changes, sometimes it was desquamated, and the walls of the tubules were represented only by a markedly thickened basal membrane. As a rule, no interstitial tissue reaction was observed at sites of microlites localization.
In the U.S.S.R. the research activities on the use of anabolic agents have been carried out only on an experimental basis by agricultural and human medicine research centres. The evaluation of the animal products from the biological point of view consisted of: 1. evaluation of the biological effect on the laboratory animals; 2. assessment of the breakdown and role of the anabolic agents in muscle tissue and the estimation of the residue amounts of the anabolic agents in meat after slaughter; 3. evaluation of the biological quality of meat obtained from treated animals. Taking into account the above-mentioned directions of the research activities, the influence of diethylstilbestrol was taken into consideration. It has been concluded that the use of diethylstilbestrol leads to detrimental results from the medical authorities' point of view.
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