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Biomedical subjects

M F Goldberg

Publications and source records attributed to M F Goldberg.

At least 127 records · Page 7Linked to original sources
PubMed1983

Evaluation for cystoid maculopathy after pars plicata lensectomy-vitrectomy for congenital cataracts.

Seventeen patients (25 eyes) who underwent a pars plicata lensectomy and vitrectomy for congenital cataract were evaluated with fluorescein angiography and angioscopy for the presence of cystoid macular edema. Studies were done from 1 month to 7 years after surgery (mean interval, 22.5 months; median interval, 12 months). Except in one eye with questionable grade 1 cystoid macular edema, the authors did not find this complication in any of their patients.

Adolescent↗
PubMed1983

Computed tomography for diagnosis of persistent hyperplastic primary vitreous (PHPV).

Leucocoric eyes with persistent hyperplastic primary vitreous (PHPV) were studied by computed tomography (CT). Maximum information was derived from use of an intravenous contrast agent and repetition of the scanning in the lateral decubitus position. Eight diagnostically helpful radiologic findings were noted, some for the first time. (1) Radiodense retrolental soft tissue can be demonstrated along Cloquet's canal. (2) The retrolental tissue enhances after administration of intravenous iodine-containing contrast material. (3) Congenital nonattachment of the retina is demonstrable by CT. (4) There may be localized or generalized increased radiodensity of the vitreous body. However, some minimally affected cases have vitreous chambers with normal attenuation values, and CT evidence for PHPV may be lacking in such patients. (5) There may also be layered, high density fluid (blood) in the retrohyaloid space, which shifts location in the lateral decubitus position. Thus far, this finding appears to be unique to PHPV, but computed scanning of other neonatal ocular conditions will be necessary before concluding it is pathognomonic. (6) There is absence of ocular and intraorbital calcification. (7) Abnormalities in configuration of the eyeball, including microphthalmos, can be demonstrated. (8) Retrobulbar tissues and other orbital structures appear normal, and the optic nerves appear normal or minimally reduced in size.

Adolescent↗
PubMed1983

Resection of uveal melanocytoma: clinicopathological correlation.

Four patients had pigmented lesions in the anterior uveal tract and choroid which presented clinically as malignant melanomas. All the lesions were successfully removed by local excision. Histopathological studies showed the tumours to be melanocytomas, indicating that enucleation or irradiation would have been contraindicated. The 3 patients with iris and ciliary body melanocytomas continue to maintain corrected visual acuities of 20/30 or better. In the patient with choroidal melanocytoma central visual acuity was compromised owing to cystoid macular oedema. All 3 melanocytomas involving the anterior segment were located inferiorly. Biomicroscopically, they were chocolate coloured (not black) and resembled malignant melanomas of the same location. The choroidal melanocytoma also resembled a malignant melanoma by ophthalmoscopic and angiographic criteria, and did not have the jet black or homogeneous pigmentation that characterises most melanocytomas of the disc.

Adult↗
PubMed1982

Autosomal dominant vitreoretinochoroidopathy.

Autosomal dominant vitreoretinochoroidopathy is a newly described fundus dystrophy characterized by abnormal chorioretinal hypopigmentation and hyperpigmentation, usually lying between the vortex veins and the ora serrata for 360 degrees. In this zone, there are a discrete posterior boundary, preretinal punctate white opacities, retinal arteriolar narrowing and occlusion, and, in some cases, choroidal atrophy. Most affected family members have diffuse retinal vascular incompetence, cystoid macular edema, and presenile cataracts. The vitreous is characterized by fibrillar condensation and a moderate number of cells. Electroretinograms are normal in younger affected individuals and are only moderately abnormal in older ones. Preretinal neovascularization, present in the posterior pole, is progressive in the proband. There are no identifiable systemic or skeletal abnormalities, high myopia, optically empty vitreous, lattice degeneration, areas of white-without-pressure, retinal breaks, or retinal detachment; thus, previously described vitreoretinopathies can be excluded from diagnostic consideration. Progression of this diagnostic seems to be extremely slow in most family members.

Adolescent↗
PubMed1982

An update on vitrectomy surgery and retinal detachment repair in sickle cell disease.

Eighteen patients (19 eyes) with sickling hemoglobinopathies underwent vitrectomy or scleral buckling operations. The indications for surgery were tractional or rhegmatogenous retinal detachment or vitreous hemorrhage. The retina was reattached in all four patients with rhegmatogenous detachments requiring scleral buckling surgery but no vitrectomy. All had excellent visual acuity postoperatively. Four of the five patients with vitreous hemorrhage requiring vitrectomy without buckling had substantial improvement in visual acuity. In ten patients with vitreous hemorrhage with either preexisting or iatrogenic retinal breaks, rhegmatogenous detachment, or tractional detachment, the rate of improvement in visual acuity was only 50%. Problems associated with vitreous or retinal surgery in patients with sickling hemoglobinopathies include iatrogenic retinal breaks, intraocular bleeding and secondary glaucoma, anterior segment ischemia, and systemic sickling.

Adult↗
PubMed1982

Scatter retinal photocoagulation for proliferative sickle cell retinopathy.

We treated sea-fan neovascularization in 19 patients (21 eyes) who had proliferative sickle cell retinopathy with localized scatter photocoagulation. We placed burns of light to moderate intensity adjacent to 45 sea fans in a scatter fashion. In general, treatment extended from 1.5 mm posterior to 1.5 mm anterior to the sea fan and one clock hour to each side of each lesion. Flat sea fans responded dramatically to treatment, with complete regression in 24 of 28 lesions. Elevated sea fans (especially large ones) responded less rapidly, with complete regression in only four of 17 lesions. Localized scatter photocoagulation is valuable in treating patients with early proliferative sickle cell retinopathy.

Adolescent↗
PubMed1982

Presumed tuberculous maculopathy.

A solitary choroidal mass underlying the macula of a patient with active pulmonary tuberculosis involuted under antituberculosis therapy. Angiographic study revealed large blood vessels within the mass and secondary changes in overlying retinal vessels. These retinal vessels, despite their ophthalmoscopic configuration, had no demonstrable anastomosis with the vascular tree of the choroid.

Adult↗
PubMed1982

Macular infarction in sickle cell B+ thalassemia.

A young black girl with sickle cell B+ thalassemia sustained macular infarction of the right eye due to multiple arteriolar occlusions. Follow-up examination revealed optic atrophy as well as microvascular abnormalities of the right macula. To the authors' knowledge, this is the first reported case of macular infarction in sickle cell B+ thalassemia.

Adolescent↗
PubMed1982

Computed tomography in the evaluation of patients with persistent hyperplastic primary vitreous (PHPV).

The computed tomographic (CT) findings in 5 patients with proven persistent hyperplastic primary vitreous (PHPV) are described. PHPV arises when the embryonic hyaloid vascular system fails to regress normally. Clinically, this condition usually manifests as unilateral or bilateral leukokoria and is one of the more important and frequent conditions mimicking retinoblastoma. The spectrum of CT findings include: (a) soft-tissue replacement (infiltration) of the vitreous body; (b) retrolental soft tissue along the Cloquet canal; (c) absence of abnormal calcification within the orbit; (d) microphthalmus; (e) retrohyaloid layered blood; and (f) hypervascularity of the vitreous humor.

Diagnosis, Differential↗
PubMed1982

Limbal palisades of Vogt.

The palisades of Vogt are distinctive normal features of the human corneoscleral limbus. Our clinical studies indicate that they are more discrete in younger and in more heavily pigmented individuals, and that they appear more regular and prominent at the lower limbus than at the upper limbus. They are seen only infrequently in the horizontal meridian. There is some symmetry (though it is not exact) from one eye to the other in the same person. The anatomy of the palisades appears to be unique for a given individual. In this respect, as well as in their microscopic anatomy, the palisades of Vogt appear comparable to fingerprints, and the term "conjunctivoglyphics" ("conjunctival carvings") or "limboglyphics" is suggested in analogy with "dermatoglyphics." The palisades of Vogt have a distinct vasculature with narrow, barely visible, arterial and venous components of radially oriented hairpin loops. Angiography reveals that these vessels leak fluorescein relatively late and only to a moderate extent. They respond to inflammation by dilatation and gross breakdown of their physiologic barrier properties. The functions of the palisades of Vogt are not known with certainty, but their interpalisadal epithelial rete ridges may serve as a repository for corneal epithelial cells. They may thus be important in both aging and diseases of the cornea.

Adult↗
PubMed1981

Chorioretinal and choriovitreal neovascularization. Their presence after photocoagulation of proliferative sickle cell retinopathy.

Delayed development of choroidally fed neovascularization represents a potentially serious complication of feeder vessel photocoagulation of proliferative sickle cell retinopathy (PSR). Of the 53 photocoagulated eyes, choroidally fed neovascularization developed in 21 within one month to seven years (mean, 32.8 months). This complication appeared in eyes treated with argon laser and xenon arc. In 11, neovascular tissue remained flat in the chorioretinal scar (chorioretinal neovascularization), but in ten, the vessels grew into the vitreous (choriovitreal neovascularization). In many cases of chorioretinal neovascularization, the only subsequent complication was local vitreous hemorrhage. Visual acuities remained near normal. The development of choriovitreal neovascularization was associated with vitreous hemorrhages or retinal detachment in six of ten cases. Final visual acuities, however, were 20/50 or better in nine. Photocoagulation in some cases converted chorioretinal neovascularization to choriovitreal neovascularization or seemed to stimulate further growth of choriovitreal neovascularization. We now recommend no treatment for most cases of choroidally fed neovascularization. Photocoagulation techniques for PSR should attempt to minimize the development of choroidally fed neovascularization.

Adult↗
PubMed1981

Diagnosing acute retrobulbar neuritis by vitreous fluorophotometry.

We studied six patients with acute retrobulbar neuritis (including two with definite multiple sclerosis) during acute episodes and in convalescence, clinically and with fluorescein angiography and vitreous fluorophotometry. We compared vitreous fluorophotometric readings with visual-evoked responses. In seven of ten eyes with abnormal visual-evoked responses, there was an acute increase in posterior vitreous fluorophotometric readings. Vitreous fluorophotometry may be useful as objective evidence of (1) acute retrobulbar neuritis, (2) involvement of the asymptomatic eye in acute retrobulbar neuritis, (3) the duration of neuritic inflammation in acute retrobulbar neuritis, (4) a recurrence of acute retrobulbar neuritis, (5) alterations in the blood-ocular barrier in patients with acute retrobulbar neuritis in multiple sclerosis, and (6) the effects of corticosteroids and other therapeutic agents in the treatment of acute retrobulbar neuritis.

Acute Disease↗