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Biomedical subjects

M F Goldberg

Publications and source records attributed to M F Goldberg.

At least 109 records · Page 6Linked to original sources
PubMed1985

The use of hyperbaric oxygen therapy in the treatment of sickle cell hyphema.

Eyes of adult albino rabbits were injected intracamerally with either normal saline or anticoagulated human sickle cell blood to study the effect of hyperbaric oxygen administration on sickle cell hyphema. The administration of two atmospheres of 100% oxygen for 2 hr to the rabbits raised the pO2 of the aqueous humor from a baseline value of 63.5 +/- 12.3 mmHg (mean +/- SD) to 620 +/- 133 mmHg in saline-injected eyes and 503.7 +/- 89.1 mmHg in eyes injected with human sickle cell blood. This rise in pO2 was highly significant (P less than 0.0001). The percentage of sickled cells in the anterior chamber 2 hr after injection decreased from 35.7 +/- 32.4% in rabbits breathing room air to 4.1 +/- 2.8% in rabbits exposed to hyperbaric oxygen for 2 hr. Hyperbaric oxygen can thus significantly raise aqueous humor pO2 values and decrease the sickling of erythrocytes in the anterior chamber and may be of value in patients with sickle cell hyphema.

Anemia, Sickle Cell↗
PubMed1984

Indications for surgical management of hyphema in patients with sickle cell trait.

We analyzed 22 sickle cell trait hyphemas. Fourteen of the 22 eyes were adequately controlled with medical therapy alone, ie, the intraocular pressure averaged less than 25 mm Hg during consecutive 24-hour periods and there were no repeated transient rises of IOP above 30 mm Hg. Surgery was performed in eight eyes, because of inadequate medical control. Thirteen of the 14 medically treated eyes had acceptable levels of IOP within the first 24 hours; only one of the eight surgically treated eyes had adequate control during the first 24 hours. This suggests that control during the first 24 hours portends a good prognosis, while lack of control during that period predicts continued difficulty managing the IOP. This seems to be important in view of previous experience that suggests that these eyes do not tolerate minimal to moderate elevations in IOP as well as those of patients without sickle cell anemia.

Anemia, Sickle Cell↗
PubMed1984

Argon laser-induced cataract. A clinicopathologic study.

A patient with diabetic retinopathy and senile anterior cortical and nuclear cataract was treated with argon laser photocoagulation of the fundus. During the treatment, white ovoid opacities appeared in the lens cortex, extending into the nucleus. They remained nonprogressive for five weeks, when cataract extraction was performed. The lens was studied by light and electron microscopy. The lenticular opacities contained rows of damaged, spindle-shaped lens fibers, with laminated cellular debris and clear spaces. We compared the unique features of the laser-induced lenticular lesions with the senile cataractous changes in the same crystalline lens.

Argon↗
PubMed1984

Vitrectomy and Whipple's disease.

We diagnosed Whipple's disease from the vitreous aspirate of two patients who underwent vitrectomies . In one case, the vitrectomy specimen would have indicated the diagnosis three years before the jejunal biopsy was performed had the appropriate PAS stain been used. In the second case, the PAS-positive macrophages were identified at the time of surgery.

Biopsy↗
PubMed1984

Vitrectomy and intravitreal antiviral drug therapy in acute retinal necrosis syndrome. Report of two cases.

Two patients with acute retinal necrosis were treated with vitrectomy, intravitreal infusion of acyclovir, and prophylactic scleral buckling procedures. Both patients have had a uneventful postoperative course and a recovery of visual acuity; follow-up has been at five and 14 months. There has been no sign of toxicity from the intravitreally administered acyclovir by electroretinographic or clinical criteria.

Acute Disease↗
PubMed1984

Argon laser destruction of anterior chamber implantation cysts.

Five patients with anterior chamber implantation cysts underwent argon laser therapy. Three cysts were eradicated and one shrunk to a small stable remnant within 1 to 5 treatment sessions. One cyst re-formed repeatedly, prompting iridocyclectomy. Follow-up ranged from 3 to 38 months.

Adolescent↗
PubMed1984

Autosomal dominant vitreoretinochoroidopathy (ADVIRC).

We report the second family recognised to have autosomal dominant vitreoretinochoroidopathy. The clinical features were (1) autosomal dominant inheritance; (2) peripheral, coarse pigmentary degeneration of the fundus for 360 degrees, with a relatively discrete posterior border in the equatorial region (this finding may be pathognomonic); (3) superficial punctate yellowish-white opacities in the retina; (4) various vascular abnormalities; (5) breakdown of the blood-retinal barrier; (6) retinal neovascularisation; (7) vitreous abnormalities; and (8) choroidal atrophy. Visual reduction was mainly due to macular oedema or vitreous haemorrhage.

Adolescent↗
PubMed1984

Inherited snowflake cataracts.

The authors report two unusual pedigrees of flake-like cataracts inherited as an isolated mendelian trait, presumably autosomal dominant. The most striking biomicroscopic feature is an accumulation of large white irregular flakes ('type B opacities') scattered throughout the equatorial cortex, with apparently less involvement of the nucleus. Some of these opacities are globular, but most are flattened and have feathery edges. These type B opacities are clinically and microscopically identical in the two families. Type B lesions are characterized histologically by irregular pale-staining areas. Ultrastructurally, these areas show large collections of microglobular degeneration immediately adjacent to normal-appearing lens fibers. Electron probe studies demonstrate normal calcium levels. 'Type A' opacities are biomicroscopically smaller, punctate, and clinically non-specific. Ultrastructurally, type A opacities include clusters of medium sized lenticular globules, each of which is larger than the individual microglobular abnormalities of type B lesions, although the aggregated type B lesion is considerably larger than an individual type A lesion. The microscopic appearance of this inherited cataract appears to be unique.

Adult↗
PubMed1984

Retrospective analysis of 58 children with retinoblastoma.

We performed a retrospective analysis of 58 children with retinoblastoma seen at the University of Illinois at Chicago between 1960 and 1982. Our findings showed an almost equal distribution by sex, a predominance (69%) of white patients, and a common presenting symptom (70%) of leukocoria, with (22%) or without (48%) strabismus. Unilateral involvement was noted in 35 patients (60%). Of the 23 (40%) bilaterally affected children, 19 had simultaneous involvement at the time of diagnosis. All bilateral and 90% of the unilateral cases were diagnosed before age five years. Family history was positive for retinoblastoma in five bilateral and one unilateral case. At the time of diagnosis, 35 patients had stage V disease (Reese-Ellsworth classification, Table 1). Depending on the stage of disease treatment included enucleation, radiation, and chemotherapy. Mortality was 25% from 1960 to 1974, and zero thereafter.

Age Factors↗
PubMed1984

Painless endophthalmitis after cataract surgery.

Pain is one of the classically described symptoms of postoperative bacterial endophthalmitis, and has been thought to be a useful and early warning symptom. Three cases, however, of culture-proved endophthalmitis presented without pain. Detection of abnormal physical findings suggested the diagnosis in each case, and led to the appropriate microbiologic evaluation and therapy. Early and frequent postoperative ocular inspection is the responsibility of the ophthalmologist. Exclusive reliance on symptoms experienced by the patient in the postoperative period is insufficient if complications such as endophthalmitis are to be diagnosed and treated optimally.

Adult↗
PubMed1984

Evulsion of the optic nerve in association with basketball injuries.

A case of optic nerve evulsion resulted from a finger poke injury to the globe during a basketball game. Significantly, almost no external damage to the eye was evident. The damage may be caused by sudden forceful anterior-posterior displacement and rotation of the globe, inducing a tear of the optic nerve at the papilla. The seriousness and permanence of this injury stress the importance of protective eye wear in contact sports.

Adolescent↗
PubMed1983

Aminocaproic acid decreases secondary hemorrhage after traumatic hyphema.

Forty-eight patients (49 eyes) had nonperforating traumatic hyphema. Twenty-eight patients (28 eyes with hyphema) received oral aminocaproic acid, an antifibrinolytic agent, in a dosage of 100 mg/kg every four hours for five days, up to a maximum daily dose of 30 g. Twenty patients (21 eyes with hyphema) received placebo in an identical regimen. One eye treated with aminocaproic acid rebled; seven eyes receiving the placebo rebled. The results of this study show a statistically significant reduction in the incidence of secondary hemorrhage in the patients receiving aminocaproic acid.

Adolescent↗
PubMed1983

Early receptor potential measurements in human ocular siderosis.

There is electrophysiologic evidence that photoreceptors have normal visual pigment density (outer segment length) at a stage of ocular siderosis when the photoreceptor membrane function is defective. The early receptor potentials (ERPs) from two patients showed normal amplitudes, although the electroretinograms (ERGs) had reduced a- and b-waves for both cone and rod ERG responses. Since the ERP is generated by photolysis of visual pigment and requires orientation of the pigment molecules by outer segment disc membranes, the normal ERP amplitudes suggest that the photoreceptor outer segments have normal photopigment density, are of normal length, and are properly oriented. However, the transduction mechanism that converts visual pigment photolysis into membrane electrical potentials (the ERG a wave) is defective at this stage of ocular siderosis.

Adult↗
PubMed1983

Retinal damage from a Q-switched YAG laser.

A 42-year-old woman with sickle cell anemia and proliferative retinopathy underwent neodymium-YAG laser therapy for a taut posterior hyaloid membrane causing peripapillary and peripheral traction detachment of the retina. Vitrectomy was not done because the patient required anticoagulation. A Q-switched YAG laser was capable of cutting holes in the taut membrane, but treatment 2 to 3 mm from the retina resulted in microperforation of a retinal vein and focal areas of damage to the retinal pigment epithelium. The damage to the retinal pigment epithelium was not immediately apparent, and ophthalmoscopically visible lesions were seen only when the patient was reexamined 48 hours later.

Adult↗