Search PubMed⌕ Search

Biomedical subjects

M Eriksson

Publications and source records attributed to M Eriksson.

At least 451 records · Page 25Linked to original sources
PubMed1981

The development of the ovary in the wood mouse, Apodemus sylvaticus.

The ovary of a young wood mouse, Apodemus sylvaticus, is filled with small follicles, which quickly become atretic. A follicle in an advanced stage of atresia leaves a hole, sometimes with demonstrable remnants of the oocyte or the granulosa cells. The secondary interstitial tissue of the ovaries appears first in association with these holes, possibly developing from the thecal cells. The presence of the secondary interstitial tissue was first observed in seven weeks old females. All the nine week old mice had well developed interstitial tissue.

Animals↗
PubMed1980

The effects of pharmacological treatment on pulmonary function in children with exercise-induced asthma.

The effects of two therapeutic regimens were investigated in eleven boys and eight girls (8--13 years) with a history of exercise-induced asthma (EIA), who reacted with subjective signs of EIA and a decrease in FEV1.0 exceeding 10% after an exercise test. A test program (TP) including complete spirometry, bicycle ergometer and treadmill exercise tests preceded and followed by dynamic spirometry at one and five min after exercise, was performed before and after each treatment period. In 12 patients with sporadic medication before the trials, continuous peroral treatment with a combination of a beta 2-stimulating drug and a xanthine derivative for three weeks did not significantly improve TP data. In 13 children (six from the above group) who were already on continuous treatment as above, addition of disodium cromoglycate (DSCG) inhalations for 3--4 weeks improved the response to acute administration of a beta-receptor stimulatory aerosol but did not influence EIA. Seven of the children continued their DSCG treatment for one year. Minor improvement of EIA provoked by cycling but not by treadmill was seen after this. The ventilatory effort in relation to working intensity was lowered. No significant differences were found between treadmill running and cycling in provoking asthma.

Adolescent↗
PubMed1980

Cytotoxic treatment in children with idiopathic nephrotic syndrome.

The purpose of this retrospective study was to investigate the therapeutic value of steroids and cytotoxics in children with idiopathic nephrotic syndrome which developed during the period 1968-1977. Thirty-eight patients were followed. They were divided into three morphological groups based on renal biopsy findings, i.e., minimal changes (MCNS, n = 34), focal segmental glomerulosclerosis (FSGS, n=2) and atypical undefined changes (Undef., n=2). In the latter two groups therapy was less successful than in the MCNS-group. This study conclusively demonstrates that cytotoxic therapy is of value in prolonging the duration of the remission and increasing the responsiveness to steroids in children with MCNS.

Adolescent↗
PubMed1980

Amphetamine addiction and pregnancy. III. One year follow-up of the children. Psychosocial and pediatric aspects.

Sixty-six infants born to amphetamine-addicted mothers were followed during their first year of life. The children were divided into three groups, according to whether or not the mother stopped her abuse in early pregnancy (Group I) or continued (Group II) and whether or not the latter children were placed in foster homes immediately after birth (Group III). All but 2 of 16 mothers in Group I stayed off drugs and mostly met non-addicted friends. In Group II, on the contrary, all but 2 of 36 mothers continued their abuse one year after delivery. At the age of one year, all but one child in Group I were in their mothers' custody and all children in Group III had remained in foster care. In Group II one-third of the children lived in foster homes after revocation of the maternal custody. Several infants in Group II had experienced multiple transfers between the biological home and different foster homes. There were indicators that maternal amphetamine abuse causes temporary drowsiness in the infants during the first months after birth. However, all children at the age of 12 months, regardless of group, had a somatic and psychomotor development in accordance with the normal Swedish standard. In all groups there was an increased rate of medical care mainly because of infections. Some infants in Group II compared to none in Groups I and III were hospitalized because of failure to thrive or suspected physical abuse. Symptoms indicating emotional disturbance were more common in infants of Group II than in infants of Groups I and III.

Amphetamine↗
PubMed1980

Infection with Mycobacterium cheloni following injections.

A 14-month-old girl with subcutaneous abscesses and purulent lymphadenitis caused by Mycobacterium cheloni following penicillin injections is presented. The case brings to the fore the differential diagnosis of mycobacterial infection in abscesses after injections.

Abscess↗
PubMed1979

Pharmacokinetics of theophylline in young children with asthma: comparison of rectal enema and suppositories.

Six children, aged 2 months - 4 years, received theophylline 5-6 mg/kg intravenously. Its disposition could be described by a two-compartment open model, the mean serum half life (t 1/2 beta) was 3.75 h, i.e., shorter than in adults, but there was a considerable interindividual variation (1.8-7.0 h, in one patient 13.3 h). Thirteen children (2 months - 4 years) received theophylline suppositories in a dose of 3.8-5.0 mg/kg, and ten (6 months - 4 years) in a dose of 8.4-14.5 mg/kg. Absorption was slow (mean half-time 43 min), incomplete and variable (biological availability 8-100%, mean 80%). Only four of the patients given the higher dose and none given the lower dose reached a therapeutic serum concentration (10-20 microgram/ml). Nine children (6 months - 4 years) received rectal enemas of theophylline 4.1-9.2 mg/kg. Absorbtion was rapid (mean half-time 5.5 min) and biological availability averaged 100%. Six patients reached a serum concentration within the therapeutic range. Using the mean values of the calculated pharmacokinetic parameters, rectal enemas providing a dose of theophylline of 6-8 mg/kg t.i.d. were computed to give serum concentrations between 8-20 microgram/ml, without producing too high a level during the absorption phase.

Age Factors↗
PubMed1979

Amphetamine addiction and pregnancy. Psycho-social and medical aspects.

The psycho-social backgrounds of 69 amphetamine-addicted mothers were investigated in order to find indicators which might be applicable in predicting the addicted women's chances of adaptation to motherhood. Of these 69 women, 17 stopped taking drugs in the first months of gestation when they realized that they were pregnant (Group 1). The remaining 52 women continued taking drugs throughout pregnancy (Group 2). There was no difference between the groups as to number of years of addiction, or other drugs used except that more women in Group 2 abused alcohol at the same time. A large proportion of the women in both Groups 1 and 2 were, as children, known to the local social welfare agencies because of their unsatisfactory home conditions. In Group 2, psychiatric illness and drug abuse were more common among parents and siblings than in Group 1. In spite of this, the women in Group 2 had, on the average, been placed in a foster home at a significantly older age. Significantly more women in Group 2 also had a poorer educational background and a criminal record including more serious crimes. At the time of their current pregnancy the women in Group 1 had a more stable social situation with regard to permanent dwelling, work and relationship with non-addicted friends.

Adolescent↗
PubMed1979

Neonatal septicemia and perinatal risk factors.

Many methods for screening and prediction of neonatal septicemia have been tried. In this study a score, related to both perinatal risk factors and neonatal diseases, was tested upon healthy newborn infants, infants with septicemia and infants with other diseases. Statistical differences were found between infants with neonatal septicemia and infants with other neonatal diseases as well as normal newborns. It was also possible to find a relationship between certain predisposing factors and predominance of certain pathogens. Complications during pregnancy and delivery were most often found in the group B streptococcal, combinations of invasive procedures and neonatal diseases in the staphylococcal group and surgical procedures in the gram-negative group.

Apgar Score↗
PubMed1979

Analysis of perinatal mortality rate in the Stockholm area.

During the period 1973--1976, a significant decrease in perinatal mortality from 14.2 to 10.4/10 newborns occurred in Sweden. In the Stockholm area, the mean perinatal mortality during the same period varied significantly between the different maternity hospitals, even when pre-term and high risk pregnancies were excluded from the comparison. The majority of hospitals with fewer deliveries and without pediatric wards had a perinatal mortality above the mean. Some explanations of these differences were also looked for in differences between the total population of the referral area of each maternity hospital. In the referral areas of the hospitals with a perinatal mortality above the mean, there were higher percentages of low-income households and over-crowded dwellings and fewer professional people than in the other area. The results suggest a need for analysis of individually-based data to find etiological factors which account for differences in perinatal mortality.

Adolescent↗
PubMed1979

Accidental poisoning in pre-school children in the Stockholm area. Medical, psychosocial and preventive aspects.

Accidental poisoning in pre-school children requiring hospital admission has increased sixfold from 1955 to 1975 in the Stockholm area. The mortality from this accident has decreased from 0.5 to less than 0.1 per 100 000 pre-school children in the whole of Sweden during the same period. Medical and psychosocial background factors were investigated in 104 consecutive in-patients (0--6 years old) with accidental poisoning and compared to an out-patient group, a group of patients who only had called the poison control centre, and a matched control group from Child Health Centres. There were no difference between the groups regarding health and history of earlier accidents except that 20--25% of the families of the poisoned children and 7% of the control families had called the Poison Control Centre before. Change of residence during the last 6 months was much commoner among families of poisoned children than of nonpoisoned. Other social stress factors were more common among in-patients than out-patients. The measures taken by the parents to combat the poisoning were adequate in most cases. The decrease in mortality inspite of the increase in potentially dangerous accidental poisonings may be attributed to a good knowledge among parents about adequate measures and where to seek advice resulting in early treatment, and to intensive care and antidote therapy.

Accident Prevention↗
PubMed1979

Neonatal convulsions. Incidence and causes in the Stockholm area.

The causes and short-term prognoses of neonatal convulsions in infants less than four weeks of age were studied in 77 full-term infants born in Stockholm in 1970--1976. In half of the infants (48%), hypoxia was considered to be the probable main etiology, while infection and metabolic disease including hypoglycemia and hypocalcemia were the next commonest cause, 12% for each condition. The etiology was unknown in 29% of the infants although 15 of those 22 included in this group had other additional diagnoses. The total mortality was 13%. At one year of age, 19 of the surviving 64 infants (30%) had severe psychomotor retardation. Of 11 infants with normal mental development at 12 months of age 6 had cerebral palsy and 5 epileptic seizures. Thirty-four (53%) of the infants still had no signs of sequelae. The poorest prognosis was found in the group with hypoxia as the main probable etiology. The incidence of neonatal convulsions was 1.5 per 1 000 full-ferm deliveries. In a similar study from Gothenburg which was performed 10 years earlier the incidence was 3.7 per 1 000. Corresponding figures for perinatal mortality rate were 13.5 and 23.8.

Asphyxia Neonatorum↗