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Biomedical subjects

M Endo

Publications and source records attributed to M Endo.

At least 1,207 records · Page 67Linked to original sources
PubMed1975

Effects of halothane on automaticity and contractile force of isolated blood-perfused canine ventricular tissue.

The effects of halothane on canine ventricular automaticity and contractility were studied in intact and isolated heart preparations in which the right anterior papillary muscle and sinoatrial node of a recipient dog were separately perfused with arterial blood from a donor animal. One percent halothane inhaled by the donor dog decreased blood pressure and heart rate in the donor animal and sensitized the ventricle of the donor dog to the arrythmic effects of norepinephrine. One per cent halothane inhaled by donor dogs also produced negative inotropic and chronotropic responses in the isolated, perfused sinoatrial and ventricular oprparations, but had no effect on positive chronotropic or inotropic responses to norepinephrine or perivascular nerve stimulation. Norepinephrine administered to donor dogs produced no arrhythmia in either spontaneously beating or electrically paced recipient hearts even though producing ventricular fibrillation in the donor. The results suggest that re-entry mechanisms play an important role in halothane-catecholamine-induced arrhythmias.

Animals↗
PubMed1975

[On glycosaminoglycans (mucopolysaccharide) in a case of pulmonary fibrosis (author's transl)].

Glycosaminoglycans from a case of pulmonary fibrosis (desquamative interstitial pneumonia of usual type) was analyzed by means of proteolytic digestion, solvent fractionation, column chromatography on anion exchanger, electrophoresis and enzymatic digestion. The result suggested an increase in dermatan sulfate and possibly of heparan sulfate in the fibrotic lung as compared with the normal. It is preferable to take the samples for analysis from a freshly excised specimen of the lung, because there was a sign of degradation of glycosaminoglycan due to storage of the specimen in a solution of formalin.

Culture Techniques↗
PubMed1975

Optimum fractionation regimen for bleomycin treatment.

A theoretical analysis was made on the optimum Bleomycin treatment regimen on the basis of the "binding-saturation model" which was proposed for the Bleomycin dose-cell survival relation. The surviving fraction of tumor cells decreased as a function of the number of fractionated treatments up to the optimum fractionation number if the tumor was treated with the same total dose. The effect of cellular sensitivity to the antibiotic, tumor doubling time, treatment interval, and total doses on the optimum regimen was analyzed. The importance of treatment interval and tumor doubling time was emphasized and the short treatment interval was recommended for the clinical use of this antibiotic. The optimum number of fractions increased linearly with the increase of the total dose while the optimum single dose was independent of the total dose. A concept of the tumor control probability of tumors treated with the optimum fractionation regimen was introduced and implications of these analyses in the clinical cancer chemotherapy were discussed.

Bleomycin↗