[Rhythm of CRF-ACTH-corticoid].
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Biomedical subjects
Publications and source records attributed to M Endo.
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From 1946 to 1976, we studied 1,329 cases of radical resection of upper and mid-thoracic esophageal cancer, a cancer whose prognosis is especially poor. Of these, 7 patients lived longer than 20 years, and 58 longer than 10 years. There were 137 patients who lived for more than 5 years. We particularly examined the ones who lived longer than 10 years, and from the findings of histological and pathological specimens we judged the malignancy grade according to the classification of histological malignancy which we had proposed earlier (cellular atypism, structural atypism, and infiltration). Malignancy grade was demonstrated to be closely associated with the prognosis and survival time.
We reported seven cases of patients with regularly recurring psychosis in close association with the menstrual cycle, who showed certain characteristics in common in regard to their age of onset, clinical picture, psychogenic factors, endocrine and EEG findings. In these patients, monoamine metabolisms in the central nervous system, fluctuating in connection with menstrual cycle, may be disturbed by emotional impact or other unknown causes thereby delicately deranging the central nervous system activity, mentally and physiologically.
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