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Biomedical subjects

M E Rose

Publications and source records attributed to M E Rose.

At least 109 records · Page 6Linked to original sources
PubMed1979

Peripheral blood leucocyte response to coccidial infection: a comparison of the response in rats and chickens and its correlation with resistance to reinfection.

The peripheral blood leucocyte (PBL) response to infection with two species of the intestinal protozoan Eimeria shows a remarkably similar pattern in both rats and chickens. Like resistance to these parasites, the PBL response to reinfection is species-specific and it coincides with the inhibition of development of the parasite and with cellular infiltration of the lamina propria. In primary infections, the numbers of PBL increased biphasically and significant changes were found in the count of polymorphonuclear cells (PMN), lymphocytes, and large mononuclear cells (LMN). A consistent pattern of two increases in PMN, some lymphopenia, and two increases in LMN was found in rats and chickens. The response to secondary infections was more rapid and much briefer, particularly in chickens in which significant changes were detected within hours of infection and consisted of an almost equal increase in PMN and in lymphocytes. This secondary response occurred only in animals challenged with the homologous species. It was not evoked by challenge with a related species which develops in approximately the same area of the intestine.

Animals↗
PubMed1978

Whipple's disease of the lung.

Described here is a unique case of Whipple's disease in a 54 year old man with chronic severe cough and gastrointestinal symptoms in whom the initial diagnosis of Whipple's disease was made by lung biopsy. This is, to our knowledge, the first reported case in which the bacilliform structures of Whipple's disease have been demonstrated in tissues from other than the gastrointestinal tract of lymph nodes. Subsequently, a peroral biopsy of the small intestine was performed and revealed identical and pathognomonic features of Whipple's disease. The pulmonary roentgenologic findings are described and the histologic differential diagnosis of histiocytic infiltrates in the lung, which may be histologically similar to Whipple's disease, are briefly reviewed.

Histiocytes↗
PubMed1977

Interactions in vitro between sporozoites of Eimeria tenella and host peritoneal exudate cells: electron microscopal observations.

The interactions of sporozoites of Eimeria tenella with peritoneal cells from normal and from immunized chickens were examined in vitro. Although the uptake of sporozoites by cells from immunized birds was greater than by cells from susceptible birds, no differences were apparent in their appearance in electron micrographs. Entry into both macrophages and heterophils (comparable to mammalian neutrophils) was by phagocytosis. The findings are discussed.

Animals↗
PubMed1977

Eimeria stiedai in rabbits: the presence of an oocyst residuum.

Observations on 5 different isolates of Eimeria stiedai from pure infections in laboratory-reared rabbits have confirmed the presence of an oocyst residuum. This structure was seen in 89--100% of the oocytes in cultures prepared both from the liver and from the faeces at different times during the patent period. The residuum consisted of 1--7 or more granules situated centrally in the oocyst and partially concealed by 4 sporocysts. The differential diagnosis of E. stiedai and E. coecicola is discussed.

Animals↗
PubMed1976

Immunity to coccidiosis: stages of the life-cycle of Eimeria maxima which induce, and are affected by, the response of the host.

An attempt was made to determine the relative importance of the different life-cycle stages of Eimeria maxima in the induction of immunity and also those stages most affected by the immune response of the host. In one experiment the life-cycle was controlled by chemotherapy but in all other experiments partial life-cycles were induced by transfers of infected mucosa between hosts. The results indicated that the second generation schizont stage is probably that most concerned in the induction of protective immunity and that sexual stages are most susceptible to immune inhibition. After initial inhibition in the immune host the earlier asexual stages were able to resume development when transferred to a susceptible host. The longer the period of exposure to the immune environment, the less able was the parasite to recover.

Animals↗
PubMed1975

Immune responses to infections with coccidia in chickens: gut hypersensitivity.

Sporulated oocysts or oocyst hulls of Eimeria acervulina given via the crop, and oocyst juice or sporozoites inoculated directly into the intestinal lumen, were tested for their effects on the hypersensitivity of the intestines of immunized and susceptible birds. Only viable sporozoites consistently caused an increase in the permeability of the immunized intestine to macromolecules, shown by the leakage of intravenously injected dye. Repulsion of epithelium and disruption of the villi were seen more often in immunized than in susceptible chickens but there was no correlation with treatment or with dye leakage. The hypersensitive response of immune intestines challenged with a heterologous organism was approximately half as intense as the response to homologous challenge. The significance of these findings in relation to immunity to coccidiosis is discussed.

Animals↗
PubMed1975

Infections with Eimeria maxima and Eimeria acervulina in the fowl: effect of previous infection with the heterologous organism on oocyst production.

Judged by oocyst production, infections with Eimeria acervulina in birds immunized with E. maxima were consistently higher than in birds which had not been immunized. Oocyst production of E. maxima in birds previously infected with E. acervulina was greater, in three out of four experiments, than in control chickens, but some of the differences were slight. The findings are discussed but no satisfactory explanation can be offered. In general there was little or no difference between the oocyst production of the individual species when present as single or mixed infections.

Animals↗
PubMed1974

Immune responses in infections with coccidia: macrophage activity.

Peritoneal exudate cells from chickens immunized with two species of coccidia, Eimeria tenella or Eimeria maxima, were examined for their capacity to phagocytose stages of the parasite in vitro. True phagocytosis of the sporozoite stage is difficult to estimate because of its ability to invade cells, but may be evaluated by comparison with control suspensions. Peak activity (compared with cells from coccidia-free chickens) was found 3 to 5 weeks after the first inoulum of oocysts of E. tenella, and 1 week after the first inoculum of E. maxima- times which correspond to the onset of complete immunity to infection. Cells from coccidia-free chickens, in the presence of serum from birds immunized with E. tenella, phagocytosed sporozoites of E. tenella in a similar manner to cells from immunized birds. The immune serum had both cytophilic and opsonic adherence properties and the latter was species specific (for the two species tested).

Animals↗