Short-course amphotericin B therapy for isolated candiduria in children.
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Biomedical subjects
Publications and source records attributed to M E Peters.
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The skeletal development of laboratory-bred owl monkeys (Aotus trivirgatus) ranging from 37 days to 58 months of age was examined radiographically. Femoral length, time of epiphyseal ossification, and fusion of various ossification centers were studied. Chronologic age can be predicted by femoral length determination up to 18 months. Initial ossification of calcaneal, tibial tuberosity, iliac crest, and ischial apophyses occurs between 5.5 and 14 months. Fusion of various secondary ossification centers allows age determination from 7.5 months to 58 months.
Nine of 56 patients with mucopolysaccharidoses (MPS) showed small tracheal diameters on their frontal chest radiographs. Autopsy of an MPS I-H (Hurler disease) patient demonstrated that the small calibre was secondary to deposition of glycosaminoglycan (mucopolysaccharide). Autopsies of two patients with other storage diseases, one with geleophysic dysplasia and one with mucolipidosis II, also exhibited compromise of their airways because of storage material accumulation.
Description of a Senior Radiology Elective, designed to teach medical students the proper sequencing of radiologic studies, is presented. We believe that in using this teaching model students will learn sequencing concepts that result in better patient care while containing costs.
To study the effects of grain dust exposure, we compared respiratory parameters between 310 grain handlers and 237 city workers of comparable age, height, weight, and smoking habits. Both populations resided and worked in the same geographic area of the United States. Information was obtained by questionnaire, interview, and examination. Pulmonary function tests included FEV1, FVC, FEF25-75, Vmax50, CV, delta N2/L, and DLCO. The prevalence of acute work-related and chronic respiratory symptoms, of auscultatory bronchi, and of airways obstruction (FEV1/FVC less than 0.7) were significantly higher (p less than 0.05) in grain handlers than in control subjects. The mean values of all lung functions except CV, delta N2/L, and DLCO were significantly lower in grain workers than in control subjects. The effects of smoking and grain handling on symptom prevalence and lung functions adjusted for age and height, analyzed by logistic regression model, were highly significant (p values ranged from 0.00001 to 0.5) and independent. The odds of having chronic bronchitis or wheezing at work were, respectively, increased 4.4-fold and 4.8-fold by grain handling and by 2.9-fold and 1.9-fold by smoking. Grain handling increased the odds of having airways obstruction 2.6-fold and smoking increased it 2.7-fold. We conclude that grain handlers have a higher prevalence of chronic bronchitis and other respiratory symptoms than do comparable workers who do not handle grain. The effect of grain dust exposure on symptom prevalence is usually greater than that of smoking. Grain handling has an adverse effect on lung function that is of the same or smaller magnitude than that of smoking.(ABSTRACT TRUNCATED AT 250 WORDS)
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It is increasingly important for mental health occupational therapists to monitor trends in reimbursement for mental health care in order to ensure adequate and equitable coverage of occupational therapy services. Federal and state funds for treatment of mental illness are being divided among an increasing number of mental health professionals. Private insurers are limiting direct coverage to those services that can supply cost and utilization information. This paper reviews present coverage for occupational therapy in mental health programs. Collection of efficacy and cost benefit data, establishment of separate billing procedures, and participation in the formation of public policies for treatment of the mentally ill should be primary activities pursued by occupational therapists to expand coverage of occupational therapy services in psychiatric settings.
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Esophageal stricture and web are described in a 14-year-old girl who presented with a history of progressive dysphagia subsequent to an episode of Stevens-Johnson syndrome at the age of 4.
A case report is presented of a bronchopleural fistula demonstrated on computed tomography (CT) scan but not identifiable on plain radiographs. The case illustrates the importance of CT in evaluating the pleural space.
A case of intramural esophageal pseudodiverticulosis in a five-year-old with a 16-year follow up is presented.
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A case of acute pulmonary toxicity due to bleomycin leading to death in 60 hours is described in an 11-year-old male with Hodgkin's disease. This acute presentation in an immunologically comprised host caused consideration of etiologies other than drugs. Previous reports in the literature have not documented such an acute fatal course as a result of bleomycin toxicity.
Two children, aged 3 months and 4 years, respectively, were treated with ten weeks of amphotericin B for culture proved pulmonary blastomycosis. Organisms were easily demonstrated in nasopharyngeal or sputum specimens on admission. Although organisms were present until the 12th and 19th days of therapy, respectively, they were viable through only the seventh and 12th days of therapy. Both patients had thrombophlebitis, anemia, neutropenia, hypokalemia, fever, and vomiting develop during therapy. The less toxic drug hydroxystilbamidine isethionate, given for only 17 to 30 days, has been used successfully in at least six previously reported cases. Long courses of amphotericin B therapy may not be necessary for the treatment of pulmonary blastomycosis in selected children.
Pulmonary functions of patients with allergic bronchopulmonary aspergillosis were studied during an acute episode (n = 6); during a mean follow-up period of 44 months (range four months--14.8 years) (n = 16); and for any correlation between duration of ABPA and asthma with the total lung capacity (helium dilution), 1 second forced expiratory volume (FEV1), vital capacity, 1 second forced expiratory volume-forced vital capacity ratio (FEV1:FVC per cent) and diffusing capacity of carbon monoxide (DL:CO) (single breath) for the entire group (n = 22). All patients were treated with corticosteroids (intermittent or continuous) and bronchodilators. For the 16 patients, slopes using linear regression analysis were determined from the function as per cent predicted versus time in months from diagnosis and then analyzed for significance. Significant functional loss was shown in three of 16 patients for FEV1, two of 16 patients for vital capacity, one of 16 patients for FEV1:FVC per cent, none of 10 patients for DL:CO and one of 10 patients for total lung cital capacity, FEV1:FVC per cent and the duration of asthma or allergic bronchopulmonary aspergillosis was found by multiple regression analysis correcting for age and smoking (mean 4.24 years; range 0.3 to 14.8 years). Roentgenographic criteria and blood eosinophilia were used to define a "flare" of allergic bronchopulmonary aspergillosis. The six patients during a flare showed a significant reduction in total lung capacity (P less than 0.001), vital capacity (P less than 0.05), FEV1 (P less than 0.01) and DL:CO (P less than 0.001) which uniformly returned to baseline values during steroid therapy. The FEV1:FVC per cent remained unaltered. These findings, contrary to suggestions in the literature, indicate that in the majority of our patients there was no significant progressive functional deterioration after diagnosis. However, during acute episodes of allergic bronchopulmonary aspergillosis, transient reduction of volumes and DL:CO were uniformly present.