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Biomedical subjects

M E Grossman

Publications and source records attributed to M E Grossman.

At least 37 records · Page 2Linked to original sources
PubMed1999

Invasive squamous cell carcinoma with sporotrichoid metastasis in a patient with cutaneous T cell lymphoma treated with chronic extracorporeal photopheresis.

An 83-year-old Caucasian man with cutaneous T-cell lymphoma developed an aggressive squamous cell carcinoma of the left forearm, which recurred and metastasized after Mohs micrographic surgery and systemic chemotherapy with cis-platin and 5-fluorouracil. He was treated with extracorporeal photopheresis, radiation therapy, PUVA photochemotherapy, and interferon therapy for cutaneous T-cell lymphoma. Aggressive squamous cell carcinoma can occur in the setting of extracorporeal photopheresis.

Aged↗
PubMed1997

Major aphthous-like ulcers in two patients infected with human immunodeficiency virus.

Two patients infected with human immunodeficiency virus (HIV) presented with persistent, large, and painful oral ulcers. Results of cultures and examination of a biopsy specimen were negative for infection and malignancy. Major aphthous-like ulcers should be considered in the differential diagnosis of oral ulcers in the HIV-infected patient.

Administration, Oral↗
PubMed1996

Orbital myositis, vitiligo, and giant cell myocarditis.

Giant cell myocarditis is a rare idiopathic inflammatory heart disease characterized histologically by multinucleated giant cells, and clinically by rapid progressive heart failure, arrhythmias, or sudden death, often within hours to days of initial symptoms. There are two previously reported cases of giant cell myocarditis with idiopathic orbital myositis. We report a similar case in a patient who also had vitiligo, a diagnostic endomyocardial biopsy, and survival because of a cardiac transplant. Giant cell myocarditis should be monitored for in the course of inflammatory orbital myopathy because of its life-threatening fulminant course.

Adult↗
PubMed1996

Acquired eyelash trichomegaly and alopecia areata in a human immunodeficiency virus-infected patient.

We describe a human immunodeficiency virus (HIV) seropositive man with acquired eyelash trichomegaly and alopecia areata. This combination of clinical manifestations is intriguing since the new onset of elongated eyelashes in patients with acquired immunodeficiency syndrome has usually been associated with severe immunosuppression and alopecia areata has a presumed autoimmune etiology that requires T cell activation. The occurrence of these dichotomous conditions illustrates the potential selective pathogenesis of progressive HIV infection.

Adult↗
PubMed1995

Multiple dermatofibromas in a woman with HIV infection and systemic lupus erythematosus.

Associations of multiple dermatofibromas with autoimmune disorders, altered immunity, or both have been described. We report the case of a 33-year-old black woman with HIV infection and an 11-year history of systemic lupus erythematosus in whom 15 dermatofibromas developed while she was receiving systemic corticosteroid therapy. Including our patient, multiple dermatofibromas have been described in 15 patients with an autoimmune disease, altered immunity, or both. All 12 of the women with multiple dermatofibromas had systemic lupus erythematosus.

Adult↗
PubMed1995

Streptococcal gangrene of the eyelids and orbit.

PURPOSE: Streptococcal gangrene, also termed streptococcal necrotizing fasciitis, is resurgent but remains exceedingly rare. Ophthalmologists and dermatologists must be aware of streptococcal gangrene, as eyelids are the most commonly affected area of the head and neck. METHODS: We studied two cases of streptococcal gangrene of the orbit with clinical manifestations indistinguishable from common nonnecrotizing orbital cellulitis. RESULTS: Infection progressed with dramatic rapidity to produce eyelid necrosis, respiratory failure, sepsis, and severe permanent visual loss caused by ophthalmic artery occlusions. Histopathologic analysis disclosed vascular thrombosis, necrosis, acute inflammation, and the presence of gram-positive cocci. Cultures grew heavy group A beta hemolytic Streptococcus. The first patient was infected with M type 1 carrying exotoxins A and B. The second patient was also infected with Streptococcus carrying exotoxin A. CONCLUSION: Early diagnosis of this life-threatening infection is of paramount importance because survival may depend on early surgical debridement.

Aged↗
PubMed1995

Herpetic geometric glossitis: a distinctive pattern of lingual herpes simplex virus infection.

Two immunocompromised patients with herpetic geometric glossitis, a clinically distinctive form of lingual herpes simplex virus (HSV) type 1 infection, are described. The significant features of herpetic geometric glossitis are summarized, the clinical differential diagnosis of this form of HSV infection is reviewed, and the possible pathogenesis of these lingual lesions is discussed. Both of our patients, as well as all previously described patients with this condition, had extremely painful cross-hatched, branched, and/or linear fissures on the dorsal aspect of the tongue. Symptoms promptly resolved within 1 to 2 days, and the fissures subsequently healed within 3 to 12 days after systemic acyclovir therapy was initiated. In contrast to tongue lesions of herpetic geometric glossitis, similar-appearing lingual lesions of other conditions are usually asymptomatic. The similar morphology of corneal dendrites in herpetic epithelial keratitis and linear fissures in herpetic geometric glossitis suggest the possibility that these HSV mucosal lesions may have a common pathogenesis.

Acyclovir↗
PubMed1995

Disseminated histoplasmosis presenting as tongue nodules in a patient infected with human immunodeficiency virus.

A 39-year-old woman infected with human immunodeficiency virus had disseminated histoplasmosis that presented with nodules on her tongue. This is the seventh reported case of biopsy- and/or culture-proven oropharyngeal histoplasmosis in patients with acquired immunodeficiency syndrome. We review those previous reports and discuss the clinical features of disseminated histoplasmosis in patients with acquired immunodeficiency syndrome.

AIDS-Related Opportunistic Infections↗