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Biomedical subjects

M E Grossman

Publications and source records attributed to M E Grossman.

At least 19 recordsLinked to original sources
PubMed1995

Multiple dermatofibromas in a woman with HIV infection and systemic lupus erythematosus.

Associations of multiple dermatofibromas with autoimmune disorders, altered immunity, or both have been described. We report the case of a 33-year-old black woman with HIV infection and an 11-year history of systemic lupus erythematosus in whom 15 dermatofibromas developed while she was receiving systemic corticosteroid therapy. Including our patient, multiple dermatofibromas have been described in 15 patients with an autoimmune disease, altered immunity, or both. All 12 of the women with multiple dermatofibromas had systemic lupus erythematosus.

Adult↗
PubMed1995

Streptococcal gangrene of the eyelids and orbit.

PURPOSE: Streptococcal gangrene, also termed streptococcal necrotizing fasciitis, is resurgent but remains exceedingly rare. Ophthalmologists and dermatologists must be aware of streptococcal gangrene, as eyelids are the most commonly affected area of the head and neck. METHODS: We studied two cases of streptococcal gangrene of the orbit with clinical manifestations indistinguishable from common nonnecrotizing orbital cellulitis. RESULTS: Infection progressed with dramatic rapidity to produce eyelid necrosis, respiratory failure, sepsis, and severe permanent visual loss caused by ophthalmic artery occlusions. Histopathologic analysis disclosed vascular thrombosis, necrosis, acute inflammation, and the presence of gram-positive cocci. Cultures grew heavy group A beta hemolytic Streptococcus. The first patient was infected with M type 1 carrying exotoxins A and B. The second patient was also infected with Streptococcus carrying exotoxin A. CONCLUSION: Early diagnosis of this life-threatening infection is of paramount importance because survival may depend on early surgical debridement.

Aged↗
PubMed1995

Herpetic geometric glossitis: a distinctive pattern of lingual herpes simplex virus infection.

Two immunocompromised patients with herpetic geometric glossitis, a clinically distinctive form of lingual herpes simplex virus (HSV) type 1 infection, are described. The significant features of herpetic geometric glossitis are summarized, the clinical differential diagnosis of this form of HSV infection is reviewed, and the possible pathogenesis of these lingual lesions is discussed. Both of our patients, as well as all previously described patients with this condition, had extremely painful cross-hatched, branched, and/or linear fissures on the dorsal aspect of the tongue. Symptoms promptly resolved within 1 to 2 days, and the fissures subsequently healed within 3 to 12 days after systemic acyclovir therapy was initiated. In contrast to tongue lesions of herpetic geometric glossitis, similar-appearing lingual lesions of other conditions are usually asymptomatic. The similar morphology of corneal dendrites in herpetic epithelial keratitis and linear fissures in herpetic geometric glossitis suggest the possibility that these HSV mucosal lesions may have a common pathogenesis.

Acyclovir↗
PubMed1995

Disseminated histoplasmosis presenting as tongue nodules in a patient infected with human immunodeficiency virus.

A 39-year-old woman infected with human immunodeficiency virus had disseminated histoplasmosis that presented with nodules on her tongue. This is the seventh reported case of biopsy- and/or culture-proven oropharyngeal histoplasmosis in patients with acquired immunodeficiency syndrome. We review those previous reports and discuss the clinical features of disseminated histoplasmosis in patients with acquired immunodeficiency syndrome.

AIDS-Related Opportunistic Infections↗
PubMed1994

Recognizing skin lesions of systemic fungal infections in patients with AIDS.

Mucocutaneous lesions may be the initial feature or a subsequent manifestation of disseminated systemic fungal infections in patients who are seropositive for human immunodeficiency virus (HIV). These lesions can be classified by their morphologic appearance as macules, nodules, papules, patches, plaques, pustules or ulcers. Some lesions mimic the morphology of conditions such as herpes simplex, Kaposi's sarcoma and molluscum contagiosum, or present as abscesses, fistulas or purpura. Since the morphologic appearance may vary, a biopsy is necessary for microbiologic cultures and histologic evaluation of any new, unusual or unexplained cutaneous or mucosal lesion that appears in any patient who is seropositive for HIV.

AIDS-Related Opportunistic Infections↗
PubMed1994

Pustular eruption after drug exposure: is it pustular psoriasis or a pustular drug eruption?

Generalized pustular eruptions with fever present a diagnostic challenge. A history of preceding drug exposure, and rapid disappearance of the eruption after the drug is stopped, suggest a drug-induced aetiology rather than pustular psoriasis. We describe and evaluate the clinical and histological features of four patients who developed a generalized pustular eruption following drug administration. The history of preceding drug exposure and the presence of a variable number of eosinophils in the inflammatory infiltrate in the lesions of these cases suggested that the generalized pustular eruptions were drug-induced.

Adult↗
PubMed1993

Chronic hyperkeratotic herpes zoster and human immunodeficiency virus infection.

A patient with human immunodeficiency virus infection had hyperkeratotic papules in the T 11 and T 12 dermatomes in which she previously had papulovesicular herpes zoster. Findings of a biopsy specimen and viral culture of these papules subsequently revealed varicella-zoster that eventually responded to prolonged high-dose acyclovir therapy and debridement. A review of reported cases of hyperkeratotic varicella-zoster infections is presented, in addition to our recommendations for the treatment of varicella-zoster infection in patients who have acquired immunodeficiency syndrome.

AIDS-Related Opportunistic Infections↗