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Biomedical subjects

M Drouet

Publications and source records attributed to M Drouet.

At least 145 records · Page 8Linked to original sources
PubMed1988

[Bibliographic review of antihistaminics H2 in the treatment of chronic (or recurrent) idiopathic urticaria].

Cimetidine alone has not been shown conclusively to be effective in the treatment of urticaria. Cimetidine in combination with an H1 antihistamine has been shown to be effective in studies of patients who could not be controlled by H1 antihistamine alone. In that section of the patient population with "untreatable" chronic urticaria, the use of an H2 antagonist in conjunction with an H1 antagonist should be considered as a possible treatment.

Histamine H1 Antagonists↗
PubMed1988

[Must the concept of intrinsic asthma be supported?].

Intrinsic asthma, defined as asthma which is not from allergy to pneumo-allergens, of cause unknown, may show several etiologies. Allergics, remembering that there in some subjects there may be small amounts of IgE on the mastocytes, with specific RAST IgE negative, skin tests only weakly positive, but with a positive provocation test to pneumo-allergens. Food allergy, isolated and associated, may also contribute a not-negligible cause. Non-allergics, responding to the frequent triggering factors: Gastro-oesophageal reflux; Neuro-endocrine origin; Infections; Physical origin (exercise). In our study, we quote two types of extremely severe asthma, linked to intolerance to aspirin and metabisulfites with others that are associated.

Asthma↗
PubMed1988

[Local and general experimental anti-anaphylactic effect of 554 L, a synthetic antihistaminic].

554 L, a synthetic histamine depressant, was first made in September 1956. In spite of the age of this compound, it seemed to us that it may be of interest to examine it for possible experimental general and localised bronchial antianaphylactic activity. In the first experiments, the results showed an anti-anaphylactic effect in guinea pigs that had been sensitised to cow milk. The second study proved that there was an anti-anaphylactic effect locally on the bronchii by an aerosol of 554 L or Hypostamine on guinea pigs that were sensitive to OVA. These results may produce development of this old compound in delayed release and aerosol presentations.

Animals↗
PubMed1988

[Type I hypersensitivity to latex].

Allergy to latex causes serious accidents that are often unrecognised. These accidents are perfectly predictable by a simple interrogation, together with skin and biological tests. Populations at risk can be identified: persons undergoing treatment, particularly the disabled and also housewives. There is a risk of further increases in the number of cases of hypersensitivity to latex due to the expanding use of preservatives. The study undertaken at the CHU at Angers has shown that allergy to fruits is frequent in patients who are sensitive to latex. The exact nature of allergy to Hevea is not yet well understood: it is not possible at present to decide whether there is "crossed allergy" or whether it is one part of a larger syndrome.

Adult↗
PubMed1987

The Diogene 4 pi detector at Saturne.

Diogene, an electronic 4 pi detector, has been built and installed at the Saturne synchrotron in Saclay. The forward angular range (0 degree-6 degrees) is covered by 48 time-of-flight scintillator telescopes that provide charge identification. The trajectories of fragments emitted at larger angles are recorded in a cylindrical 0.4-m3 Pictorial Drift Chamber (PDC) surrounding the target. The PDC is inside a 1-T magnetic field; the axis of the PDC cylinder and the magnetic field are parallel to the beam. Good identification has been obtained for both positive and negative pi mesons and for hydrogen and helium isotopes. Multiplicities in relativistic nucleus-nucleus reactions up to 40 have been detected, limited mainly by the present electronics.

Elementary Particles↗
PubMed1987

[Hyper-accelerated immunotherapy with Hymenoptera venoms].

Hyper-accelerated immunotherapy with hymenoptera venoms. Immunotherapy with hymenoptera venoms can be done in 3.5 to 6 hours, in a hospital environment with the precaution of having made a threshold of cutaneous sensitivity. The 3.5 h technique should only be used for subjects who are weakly sensitive to wasp venom. The 6 h technique should be used for: Subjects with weak sensitisation to been and hornet venom. Those who are strongly sensitive to wasp venom. The 3 day technique should be used for those who are strongly sensitive to been and hornet venom. This division of the indications is essentially based on skin tests. By its use, systemic reactions or indeed anaphylaxis that may occur during desensitisation may be avoided.

Anaphylaxis↗
PubMed1987

[Intolerance to metabisulfites in asthma induced by aspirin].

38% of subjects who presented with aspirin (Acetyl-salicylic acid AAS)-included asthma were also found to be intolerant to metabisulphites (MBS). The diagnosis was based on interrogation and an oral provocation test (TPO), to which the majority of the responses were similar, immediate and/or delayed. Atopy and other immunological tests are not involved in this type of asthma, which like AAS is has an intolerance mechanism.

Administration, Oral↗
PubMed1987

[Reactions to metabisulfites in aspirin-induced asthma].

We have observed in some patients that some Aspirin sensitive asthmatic present also a dyspnea after wine or foods containing sulfites ingestion. Owing to a study using ingestion test, with spirometric control, we show that sulfite sensitive asthma is more frequent in patients with Aspirin sensitive asthma than in the others. In the two cases, these molecules trigger off an asthma attack with same symptomatology, same severity, that is to say, frequently of IV type, with corticodependance. Diagnosis allow to an adapted treatment and so a better prognosis of these asthma.

Adult↗
PubMed1987

[Identification of common antigens of Phleum pollen and wheat. Preliminary study].

The typing of common Phleol Pollen and wheat Antigen has been realized with these Antigens Fractions from PASTEUR Institute using FPLC PHARMACIA Chromatograph. The discover of commun Antigen has been obtained with RAST Inhibition technic. It exist common Antigen fractions between phleol and wheat, but no between wheat an phleol. The results are in favor of less allergic quality of wheat.

Allergens↗
PubMed1986

[Interpretation of reactions to acetylsalicylic acid and glaphenine].

Challenge test puts in evidence the responsibility of a drug. The biological checking by plasmatic histamine leads to distinguish between a specific histamine-release reaction and a non-specific one. Thus, glafenine has proved to be a non specific histamine release where as in some cases, acetyl-salicylic-acid (A.S.A.) behaves like a specific histamine release.

Adult↗
PubMed1986

[Management of suspected allergy to lidocaine].

General Anaesthetics are potentially more dangerous than local anaesthetics. Among the achievement of 25 provocation tests, it always shows good tolerance of the local anaesthetic, included in patients who had presented serious disorders after a previous local anaesthesia. Consequently, the local anaesthetic wasn't the real cause. However, there is to say that in one case 45 minutes after challenge, hand oedema (occurred). Research of hypersensitivity, remains very necessary in every doubtful case.

Drug Hypersensitivity↗
PubMed1986

[Type III (Arthus) reaction during desensitization].

We rapport an original observation of adverse reaction (Arthus reaction) during a dust mite hyposensitisation with a aluminum hydroxide absorbed extract. We precise the way of beginning. In discussion, we try to precise the preliminary symptoms of such reaction to prevent it.

Adult↗
PubMed1986

[Diagnosis of drug-induced allergy].

Drug allergy must be in relation with a phenomenon of immunopathology which induces: Anaphylactic shock; Toxidermia; Cytopenia; Allergic Hepatitis. Diagnosis is based on the cutaneous testing and "in vitro" tests. The evidence of drug responsibility will be supplied by challenge test, practised in hospital according to special conditions. Treatment is preventive with cortisone, epinephrine, antihistamine. Treatment is also curative with those same drugs in respect to the clinical pathology.

Drug Hypersensitivity↗
PubMed1986

[Effects and complications of specific immunotherapy].

During the specific immunotherapy, we observe: -local reactions -systemic reactions. In most cases, it is an exacerbation of clinic symptomatology which may reach others organs nearby. Reactions will occur more or less quickly according to the kind of the extract: aqueous or delayed. Clinically, systemic reactions can induce a general trouble or an anaphylactic shock. Numerous causes could be at the beginning of these systemic reactions in relationship to an antigenic overdose or to a promoting state of health. We can observe systemic reactions at most for grass pollens or hymenoptera venoms. Standardisation of allergens is not riskless. On the opposite, it needs a best knowledge of standards which change from one laboratory to another. During specific immunotherapy of hymenoptera venom, when histamine release is positive again in more than sixty per cent we can observe correlation with systemic reactions. Epinephrine is mostly essential in treatment of anaphylactic reaction. Prevention of incidents and accidents of specific immunotherapy depends on a clinical care. This can be obtained by an expert of allergy who will be in relation with the family doctor.

Bee Venoms↗
PubMed1986

[Complications induced by general anesthetics].

We reported 38 observations with adverse reactions during anesthesia. These observations have collected over about one year. For each observation we studied some parameters like sex, aspect of the adverse reaction, number of general anesthesia before the accident, atopy, age etc. Among the parameters, we noticed the great frequency of reaction in the female group (81.5%) and an increased level of total IgE (greater than or equal to 150 Ul/ml) in 38%. For each investigated drug we realized skin test (Prick-test and when negative, intra-dermal test) and Lymphoblastic Transformation Test L.T.T.). The examinations are compared each other for a best diagnosis: when skin test (ST) and L.T.T. are together positive the allergic reaction is likely. when ST and L.T.T. are together negative, it is likely there is not allergic reactions with this drug. when there is a discordance between ST and L.T.T. prudently we recommend to avoid this drug for future anesthesia. Results of ST and L.T.T. are detailed for the 3 drugs which are more often investigated. That is to say: Thiopental, Suxamethonium, Fentanyl.

Adolescent↗