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Biomedical subjects

M Drouet

Publications and source records attributed to M Drouet.

At least 127 records · Page 7Linked to original sources
PubMed1991

[Allergy survey in genital contact dermatitis].

Contact eczema is one of the most frequent dermatological affections, regardless of age and sex. In typical cases, the diagnosis is usually easy, but it may be less so where there are atypical factors, in particular locations and with complications or unusual etiological data. In fact, the first condition in making a diagnosis is to suspect that there is the possibility of contact allergy. As an example, it should be remembered that allergy to benzalkonium can be diagnosed after a mean time of 87 months of evolution. The present availability of standardised allergens for testing for contact allergens has greatly changed the diagnostic possibilities. The allergens that are most often the cause in the genital region are perfumes, chlorhexidine, hexamidine, benzylalkonium chloride and latex. Only recognition of the allergen and its removal are used and sufficient to obtain recovery.

Allergens↗
PubMed1991

[Refractory vaginal candidiasis].

Genital candidiasis is a poorly-studied pathology, certainly because there is often a favourable result after treatment, at least in times past. If the diagnosis of acute vulvo-vaginitis is easy, it is not the same in relapse or second attack. The correct treatment of refractory vaginal candidiasis and/or second attacks needs a knowledge of their etiology, the mechanisms that encourage their appearance (and maintenance), the field where they occur. Recent data on the action of Candida on immunity may introduce new physiopathological perspectives and treatments.

Candidiasis, Vulvovaginal↗
PubMed1990

Affinity immunoblotting detection of serum monoclonal immunoglobulins reactive with glycosphingolipids.

The characterization of serum monoclonal IgM reactive with glycosphingolipid present in the nervous system is of major importance in patients with certain neuropathies. A rapid, sensitive and specific one-step method which permits such a characterization is described. Serum immunoglobulins separated by high resolution agarose electrophoresis are transferred to affinity filters (nitrocellulose sheets coated with glycolipids), and revealed with enzyme-tagged monospecific anti-immunoglobulin antibodies.

Antibodies, Monoclonal↗
PubMed1990

[Treatment of asthma].

Treatment of asthma needs recourse to methods: Curative and preventive, Symptomatic and etiological. Control of the different therapeutic methods is necessary for good patient care.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1990

Urticaria with macroglobulinaemia. Disease activity associated alterations in immunoglobulins profile and bone marrow hypodiploidy.

A case of chronic urticaria-like lesions with macroglobulinaemia (Schnitzler syndrome) is described. This case is unique by its double IgM monocomponents and by the follow-up study which shows immunoglobulins modifications between cutaneous flare-up and remission. As 1 case had a lymphoma, we studied the mononuclear cells of the bone marrow of Schnitzler syndrome to raise a possible malignant evolution of that disorder, and we discovered a hypodiploid population, which we compared with similar studies of myeloma and monoclonal 'benign' gammopathies.

Aged↗
PubMed1990

[The immunopathology of asthma].

Allergic asthma has an immunological mechanism of immediate hypersensitivity, of the Type 1 in the classification of Gell and Coombs. This article considers recent data concerning immediate hypersensitivity that complicate the original plan and give the priority: at the cellular level: mast cells at the mediator level: histamine.

Antigens, Differentiation, B-Lymphocyte↗
PubMed1990

[Mercury--is it a respiratory tract allergen?].

Mercury is a well-known allergen in dermato-allergology, often manifesting as delayed type hypersensitivity contact eczema. Immediate hypersensitivity reactions (urticaria, anaphylactic shock) have also been described for this allergen, most frequently seen in patients with the delayed type contact eczema. To our knowledge this allergen has not been implicated in production of respiratory symptoms. We describe a patient who had aggravation of asthma by mercury contained in dental amalgam. When the dental amalgam was removed there was a great improvement in his asthma. This observation suggests that mercury in the form of dental amalgam may also be an allergen of the respiratory tract, which should not be surprising, bearing in mind the work that shows the existence of mercury vapours from dental amalgam.

Adult↗
PubMed1990

[Perennial rhinitis from food allergy].

Food allergy (AA) is involved in a third of subjects with perennial rhinitis (RPA). The majority of the patients are polysensitized. Isolated food allergy was only seen in 6 of 261 cases, which indicates an association of food allergy with other allergens, essentially pneumo-allergens. Immediate diagnosis of AA in RPA is difficult as it is essentially based on tests of elimination and re-introduction of the food, skin tests and RAST.

Adolescent↗
PubMed1990

[Rhinomanometry: indications, limitations and results].

The aim of this study was to present briefly the different techniques for measurement of nasal resistance and to show the importance that we attribute to this measurement. Within the framework of the allergological investigation rhinamometry is a parameter that allows evaluation of the results of allergenic nasal provocation. Nasal provocation is in the framework as a complementary examination that is often indespensable to confirm with most possible certainty the involvement of an allergen in the ORL pathology. Positive etiological diagnosis is a fundamental basis for therapeutic advice.

Airway Resistance↗
PubMed1990

[Fernand Widal syndrome and sulfite intolerance. Therapeutic problems in general and ORL problems in particular].

Asthma from intolerance of sulphites has been the subject of clinical work by our team since 1984. In 1986, we advised that asthma from sulphite intolerance was more frequent in patients who presented with illness from aspirin or the Fernand Widal syndrome. So it has emerged that there are clear therapeutic problems since sulphites as preservatives are present in other forms in some anti-allergy drugs, anti-histamines used for ORL.

Aspirin↗
PubMed1990

[The environment and perennial rhinitis in the child].

In assessing the importance of the "allergen eviction" factor in the treatment of infantile allergies, the authors begin an inventory of those elements in the environment that concern perennial rhinitis. From 200 observations of allergic children (all mixed diagnoses) they found 21 observations of rhinitis alone, predominantly boys. The environments of two groups (all allergics--rhinitis alone) were compared. No difference for: Home, country, town heating allergens found. Found significant differences for the type of house new-old those elements of domestic comfort (carpets, feather beds, aeration, soft toys) agreement between the results of tests and the environment domestic animals or permanent proximity. Found fundamental differences for psychological environmental factors (absent in rhinitis). It seems that perennial rhinitis probably arises from abundance of domestic antigens more than for the other allergic manifestations, as the nose is the first filter to receive foreign particles.

Adolescent↗
PubMed1989

[Anaphylaxis induced by exercise].

Exercise-induced anaphylaxis EIA is a syndrome most often initiated by food allergy. Objective or diagnostic proof of the condition is shown by a provocation test from ingestion of a food before or after exercise, according to clinical history, with assay of plasma histamine and spirometry or rhinamometry. The original part of this work is evidence of EIA linked to food allergy to wheat, with cross reactivity to grass pollens.

Adolescent↗
PubMed1989

[Rare etiologies of asthma--bibliographic review].

To understand the rare causes of asthma can only diminish the group of intrinsic asthma. The rare etiologies that are cited in this article are not exhaustive. We recall successively from the pneumoallergens, the rare domestic etiologies as well as the work-induced allergies that pose an interesting physiopathological problem. We state that asthma = pneumoallergens is not a valid equation and that, confronted by an asthmatic patient, the etiological enquiry should not be limited to pneumoallergens. In effect we cite work that concerns food allergies, asthma due to preservatives and various food additives, asthma due to dermatophytes and finally an exceptional case of asthma due to seminal fluid.

Asthma↗
PubMed1989

[Role of food allergy in atopic dermatitis].

Food allergy is one of the main causes of atopic dermatitis. Its frequency was established at 41.3% in our study. Eggs, cows milk and wheat were the foods most often responsible for DA. Proof by elimination-reintroduction is the best diagnostic criterion in food allergy, leading to suppression of the food if its nutritional importance permits this. This food suppression leads to 84% clinical improvement of DA.

Adolescent↗
PubMed1988

[Antihistaminic or anti-degranulating activity of pregnancy serum].

From observation of women who had anaphylactic accidents to hymenoptera venoms, with positive histamine release, we have noticed that these same patients lose their histamine release during pregnancy. Measurement of histamine release to pollens confirms the existence of a histaminase, which develops from the third month of the pregnancy and which is the origin of the loss of histamine release. This study makes eliminates a possible anti-degranulation ability of pregnancy sera.

Amine Oxidase (Copper-Containing)↗