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Biomedical subjects

M Dehan

Publications and source records attributed to M Dehan.

At least 163 records · Page 9Linked to original sources
PubMed1980

[The value of haematological data in the diagnosis of foetomaternal infections (author's transl)].

In a systematic prospective study the levels of mature polymorphonuclear neutrophils (PMN), unsegmented band cells, platelets and fibrinogen were measured during the first 5 days of life. 240 neonates of less than 2 days of age admitted to an intensive care unit were compared with 173 normal infants ("control" group) and 15 infected babies ("infected" group). The changes of PMN with gestational age and during the early days of postnatal life were determined by statistical analysis of the results in the "control" group. The results of the "infected" group demonstrated the change of PMN and unsegmented cells from the day of infection. This data should be used to interpret the levels of PMN, unsegmented band cells and together with the abnormalities in the platelets and plasma fibrinogen levels underlines the value of haemotological tests in the early diagnosis of foetomaternal infections.

Bacterial Infections↗
PubMed1980

[Pulmonary and bone maturation. Study of 36 neonates (author's transl)].

Pulmonary surfactant deficiency was diagnosed in 36 newborn infants by measuring low L/S ratios in sequential tracheal aspirated samples. A distal femoral epiphysis was seen in knee X-rays in 25 of these 36 infants. It is concluded that fetal pulmonary maturity cannot be judged in utero by the presence of ossific centres at the knee, although there is a statistical correlation between gestational age and maturity of the bones.

Bone and Bones↗
PubMed1980

[Twin pregnancy, indomethacin and neonatal cyanosis (author's transl)].

Two twins born to a mother who had been treated with Indomethacin at the end of pregnancy presented with variable but transitory hypoxemia. Blood Indomethacin determination suggested that this disorder was iatrogenic in origin. Clinical, experimental and pharmacological data in the literature support the hypothesis that this condition was due to pulmonary arterial hypertension.

Adult↗
PubMed1979

Conservative management of patent ductus arteriosus in preterm infants.

We report our experience of medical treatment, chiefly based on prolonged artificial ventilation, of 33 preterm infants with PDA and heart failure whose survival rate was 88%. All of them had clinical criteria used by others to indicate surgical ligation of the ductus arteriosus. This conservative approach seems to give better results than surgical ligation, despite a high frequency of bronchopulmonary dysplasia among survivors.

Ductus Arteriosus, Patent↗
PubMed1979

The number of polymorphonuclear leukocytes in relation to gestational age in the newborn.

173 distressed newborn infants without evidence of bacterial infection were investigated at 12-hour intervals for the number of polymorphonuclear leukocytes during the first 5 days of life. The results showed a significant difference in the number of polymorphonuclear leukocytes in relation to both gestational and post natal ages. The study stresses the necessity of taking into account these differences in interpreting neutropenia as a sign of bacterial infection in neonates.

Age Factors↗
PubMed1979

[Neonatal hematemesis caused by peptic esophagitis].

Five full term neonates presented with haematemeses on one of the first three days of life. All but one had been given vitamin K at birth. Two out of five had clotting abnormalities that suggested vitamin K deficiency. All had evidence of hiatus hernia and, on oesophagoscopy, had evidence of peptic oesophagitis. Bleeding is another complication of neonatal peptic oesophagitis.

Blood Transfusion↗
PubMed1979

[Neonatal renal papillary necrosis].

Renal papillary necrosis was detected early by plasma and urine analyses in a neonate with the respiratory distress syndrome. The intravenous urogram demonstrated characteristic features of the condition. Initial symptoms were polyuria, urinary salt loss and haematuria, but the only residual abnormality was a mild defect in urinary concentrating ability.

Hematuria↗
PubMed1979

[Laboratory diagnosis of hyaline membrane disease and amniotic fluid inhalation. A study of 100 neonates with respiratory distress].

The aim of this study of 100 newborns with respiratory distress in the first 24 hours was to evaluate the diagnostic reliability of sequential L/S ratio testing of the fluid retrieved through tracheal suctioning in identifying hyaline membrane disease and that of calculating the urinary meconial index (UMI) for the first mictions in identifying amniotic fluid aspiration. The L/S ratio was found to be low (< 2) during the first 3 days in 90% of the cases of hyaline membrane disease; this good correlation shows that the technique employed here can reliably be used to diagnose clinically and radiologically atypical forms of this disease (12%). The UMI was found to be abnormally elevated (> 1) in all the cases of severe meconial aspiration. This result implies that minor or atypical cases or those in which another disorder is associated can be diagnosed by the test. It is therefore proposed that the concurrent use of these two tests would improve the accuracy of the etiological diagnosis of respiratory distress in newborns.

Amniotic Fluid↗
PubMed1979

[Umbilical artery catheterization by cut-down study in 34 newborn infants].

In some newborns with vital distress, conventional umbilical artery catheterization cannot be performed: in our series, this occurred in 34 out of 248 attempts. In 28 of these 34 infants, catheterization succeeded when hypogastric cut-down of an artery was carried out. Two of the 6 failures were due to a minor complication at the time of the cut-down, while two others occurred in infants presenting a single umbilical artery. The usual cuse of failure of conventional catheterization is probably laceration of the artery wall and ensuing subintimal fistulas and perforation.

Catheterization↗
PubMed1978

Idiopathic arterial calcification in infancy. A case report.

An infant with idiopathic arterial calcification is presented. The disease was diagnosed during the life of the patient as an aortogram demonstrated a stenosis of the left coronary artery and complete occlusion of the right coronary artery.

Aortography↗
PubMed1978

Diagnosis of meconium aspiration by spectrophotometric analysis of urine.

The first urine passed by a newborn infant who has inhaled meconium or meconium-stained amniotic fluid often contains a dark-coloured water-soluble substance, recognisable spectrophotometrically by an absorption band at about 405 nm. Spectrophotometric analysis of the first urine can in this way be used to diagnose preceding meconium aspiration.

Humans↗
PubMed1977

Red cell volume measurements and acute blood loss in high-risk newborn infants.

Red cell volume was measured in 259 infants admitted to a high-risk newborn unit. Red cell volume was measured using 50Cr tagging which subsequently was activated to 51Cr for counting. Total blood volume was calculated using the corrected whole body hematocrit. A low red cell volume was frequently associated with a maternal history of vaginal spotting, with placenta previa or placenta abruptio, with nonelective cesarean section, and with deliveries associated with cord compression. Asphyxiated infants without a history suggestive of blood loos often had a low red cell volume. An early central hematocrit below 45% correlated with a low red cell volume, but a normal or high hematocrit was often associated with low red cell measurements. The total blood volume depended largely on whether the tagging was done long enough after the blood loss for plasma volume equilibration to have occurred. Very low red cell volume values were associated with a high mortality rate, but birth weight played a dominant role in survival, even at low red cell volume levels.

Asphyxia Neonatorum↗
PubMed1977

[Convulsions in the fifth day of life: a new syndrome?].

Among a series of 98 newborns who experienced neonatal seizures, 20 of them were individualized for they illustrated a "new syndrome": "the seizures of the fifth day of life". These patients were born at term, their maternal and natal history was unremarkable. Seizures always began around the fifth day and most often constituted a real electro-clinical état de mal. EEG reveals alternating sharpened theta waves, a pattern which seems to be characteristic. Some 6 days later, children recovered completely. Further evolution appeared to be always favorable. Although etiological enquiry remained negative, many facts suggested a viral etiology. This syndrome is probably frequent as it was also observed in other neonatal units.

Electroencephalography↗