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Biomedical subjects

M Dehan

Publications and source records attributed to M Dehan.

At least 145 records · Page 8Linked to original sources
PubMed1984

[Perinatal symptomatology of severe neuromuscular diseases. Apropos of 11 cases].

The neonatal diagnosis of neuro-muscular diseases is difficult. From a series of 11 neonates presenting with such diseases, ante and postnatal semiology has been studied. During pregnancy, hydramnios (7/11) and decreased active movements were the most frequent symptoms. Delivery was often dystotic (7/11). After birth, respiratory distress, lack of motility, hypotonia, and muscle and tendon retraction were the clinical manifestations (10/11). Knowledge of this semiology should facilitate the ante and postnatal screening of affected patients. The diagnosis depends on family history and, overall, on the results of muscle biopsy.

Biopsy↗
PubMed1984

[Severe neonatal thrombopenia. Analysis of the etiologic data on 64 cases].

In many cases of neonatal thrombocytopenia, etiology does not fit with usually known causes. Analyzing, in an intensive care unit, 64 cases of severe neonatal thrombocytopenia (platelets less than 50 x 10(9)/l before hour 72), the authors attempted to determine other possible causes of the disorder. In this study, classical etiologies were present in 33% of cases. In the other 67%, hypotrophy and/or hypoxia were significantly more frequent (p less than 0.01) than in the first group. With reference to clinical and experimental data in the literature, the possible role of acute or chronic hypoxia as a cause of thrombocytopenia is discussed.

Acute Disease↗
PubMed1984

[C-reactive protein and neonatal infections. Diagnostic importance].

Serum C Reactive Protein (CRP) levels were measured in 36 neonates with a suspicion of sepsis. In the 11 children in whom septicemia was proven, CRP levels were abnormal in all cases, while hematologic data were significantly changed in 3 cases only (27%). In the 16 neonates who were not infected, CRP was abnormal in only one case, and hematologic data significantly changed in 2 (12%). In 9 neonates with at least 2 peripheral samples positive for the same organism, CRP and hematologic data were respectively abnormal in 6 (66%) and one (11%) cases.

Bacterial Infections↗
PubMed1983

Coproporphyrin in urine of newborns with meconium aspiration syndrome.

We evaluated coproporphyrin in the first urine passed by newborn infants with and without meconium aspiration, by spectrophotometric analysis and thin-layer and "high-performance" liquid chromatography. Urines of newborn infants without meconium aspiration contained only very small quantities of coproporphyrin, detected, after partial purification, by "high-performance" liquid chromatography. Urines of newborn infants with meconium aspiration contained large quantities of coproporphyrin, identified by all three techniques. Urinary coproporphyrin as measured spectrophotometrically correlates well with the "urinary meconium index," and the method is simple, rapid, and reliable, even for samples containing hemoglobin.

Chromatography, High Pressure Liquid↗
PubMed1982

Fifth day fits.

Explore the source record for details and available documents.

Humans↗
PubMed1982

[Heart disorders following perinatal anoxia (author's transl)].

Various types of ischemic myocardial dysfunction can be observed after perinatal anoxia. Seven such cases are reported: 2 patients with cardiogenic shock due to left ventricle myocardial infarction; 2 patients with transient tricuspid insufficiency; 3 patients with transient myocardial ischemia in the course of a severe respiratory illness.

Cardiomyopathies↗
PubMed1982

[Biochemical aspects of amniotic fluid aspiration].

The authors propose a simple, quick and reliable biochemical method for diagnosis of amniotic aspiration in the newborn infant. The optical density of the infant's first urine is determined at 420, 390 and 405 nm. A urinary meconial index (IMU) is computed from these values. A meconial amniotic inhalation must be suspected if this index is greater than one. The presence of coproporphyrins identified in urine of infants having inhaled meconial amniotic fluid seems to be at the origin of the spectral characteristics of pathological urines.

Amniotic Fluid↗
PubMed1982

[A study of the perfusion of the ventilated alveolar areas in hyaline membrane disease].

Thirty-three neonates presenting with hyaline membrane disease were investigated with simultaneous measurements of PACO2 and PaCO2, in order to establish the percentage (q) of the ventilated alveolar areas with little or no perfusion. Results show that during the acute phase of the disease, mean values for q are 40%. Highest figures are related with the most severe distress. In such cases, major pulmonary hypoperfusion is associated with extrapulmonary right to left shunts, as shown by a PO2 gradient between a pulmonary vein and the aorta. Later on, q values improve progressively. The importance of the reduction of the perfusion of the ventilated alveolar areas and its hemodynamic consequences suggest that in severe cases with hyaline membrane disease a pulmonary vasodilatator treatment could be prescribed, before the stage of refractory hypoxemia.

Female↗
PubMed1981

[What's new about the fifth day seizures syndrome? (author's transl)].

This paper concerns 37 newborns who suffered clinical seizures from their 24th h till their 10th day of life, excluding post-anoxic seizures or convulsions leading to death. Continuous or repeated EEG recordings were performed for all babies: 25 infants had electro-clinical recorded seizures, 12 children did not have another convulsion after admission. This work allows us again to isolate a group of 18 newborns who presented the clinical and EEG features described as the 5th day seizures syndrome: term babies, appearance of first seizures between the 4th and 5th day, very frequent status epilepticus, almost constant inter-ictal 'sharp alternating theta' tracing, immediate spontaneously favourable evolution. A long-term follow-up was done on this group (18 children) and on the initially described group of 20 children: only 2 children had seizure recurrences, essentially febrile seizures, in spite of lack of long-lasting anticonvulsive therapy.

Brain↗
PubMed1981

[Clofibrate for the treatment of hyperbilirubinemia in neonates born at term: a double blind controlled study (author's transl)].

A double blind controlled study of the therapeutic effect of clofibrate, an inductor of bilirubin glucuronyl transferase, was performed in neonates born at term and presenting with physiologic jaundice. 47 children were treated with a single oral dose of clofibrate. 46 control children were given corn oil alone. Results show that mean plasma bilirubin levels are significantly lower in the treated group as compared with the control group, from the 16th hour of treatment, if there is no ABO incompatibility. Clofibrate treatment also resulted in a shorter duration of jaundice and a restricted use of phototherapy. No undesirable side-effect was observed.

ABO Blood-Group System↗
PubMed1981

[Simultaneous assessment of intra-pulmonary right-to-left shunting and of aADCO2 in 5 neonates with refractory hypoxemia (author's transl)].

Five neonates with refractory hypoxemia (aortic PO2 less than or equal to 6.7 KPa despite FiO2 = 1 and efficient artificial ventilation) were investigated in order to determine the principal mechanism of hypoxemia. PO2 values were measured (under FiO2 = 1) in a pulmonary vein, the left auricle and the aorta. They were used to distinguish intra-pulmonary shunts from extra-pulmonary shunts (though foramen ovale and/or ductus arteriosus). Simultaneous measurements of PACO2 and PaCO2 were used to assess the percentage of the ventilation output reaching hypoperfused areas. In cases with extra-pulmonary shunt, when this percentage is over 30%, pulmonary hypertension is likely. The use of both methods is useful for selecting those patients who might benefit from tolazoline.

Blood Gas Analysis↗
PubMed1980

[Hyaline membrane disease in full-term neonates (author's transl)].

Eleven full term neonates with respiratory distress syndrome resembling hyaline membrane disease (HMD) are reported. Gestational ages awere assessed from the history and by clinical and EEG criteria. The diagnosis of HMD was made when clinical and radiological signs, usually present in premature infants, were found together with an abnormal lecithin/sphingomyelin ratio in the tracheal aspirate during the first 60 hours. In the majority of newborns all organs should be mature after 37 weeks gestation but, development may be delayed. Thus the lungs in the full term infants may occasionally have an immature surfactant system.

Female↗
PubMed1980

[The diagnostic value of the EEG in peri- and intraventricular haemorrhage in the newborn (author's transl)].

EEGs were performed in 39 newborns with intraventricular haemorrhage (IVH) who subsequently died and compared with a series of 37 neonates who did not have an IVH. Abnormalities were more common in the IVHgroup. The most significant findings were the presence of electrical storms and that it was not possible to assess the gestational age. Positive rolandic spikes were not significantly more frequent in the IVH group. None of the EEG changes seem to be specific for IVH, but the presence of any of these in a premature infant makes an IVH highly probable.

Cerebral Hemorrhage↗