Toxicity of metronidazole and sodium ascorbate to hypoxic SV40-transformed 3T3 cells [proceedings].
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Biomedical subjects
Publications and source records attributed to M Dawson.
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Two cases of internal pancreatic fistula, causing pancreatic ascites, were demonstrated by the use of ERCP. This new technique is a useful way of establishing the diagnosis, and treatment may in the future be determined by the ERCP findings.
A 48 year old premenopausal woman presented with galactorrhea and amenorrhea associated with chest wall burns. Basal serum prolactin levels were raised, and were further elevated by the administration of L-dopa, chlorpromazine and TRH. Intercostal nerve block and bromocryptine treatment reduced prolactin levels to normal, but did not noticably reduce milk secretion.
Markedly T lymphocyte depleted rats were prepared by thymectomy, irradiation, and repopulation by bone marrow hematopoietic and lymphoid cells. Such rats had persistent T lymphopenia of about 20% of normal. When T depleted and normal rats were injected with adjuvant, all animals developed arthritis but with slightly less severity in the T depleted animals. Such experiments, and other observations, suggest a complex immunological mechanism in the pathogenesis of adjuvant arthritis in the rat.
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A retrospective review of 149 patients receiving 162 renal transplants showed that 83% of these patients developed one or more infections during a follow-up period averaging one year. In 32 (73%) of 44 deaths, infection was an important contributing cause. In only four (9%) of the deaths were the patients free of infection at the time of death. The Klebsiella-Enterobacter group was the most common agent causing pneumonitis and sepsis. Cryptococcus neoformans caused seven of 11 cases of meningitis. Pseudomonas was the most frequent agent associated with infections documented during postmortem examinations. In a short-term controlled study comparing daily and alternate daily therapy with prednisone, the alternate daily group had significantly (P less than .05) more infections per patient, especially in patients who had no evidence of rejection (P less than .025).
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