Measurements of urinary steroids do not allow a precise supervision of the evolution and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Thirty-one cases with a 2 year follow-up allowed a trial of estimation of the progress that could be obtained with plasmatic dosages of renine, testosterone, A.C.T.H. and 17-hydroxyprogesterone (17-O.H.P.) activities. The best way for reaching diagnosis is presently 17-O.H.P. However, the amplitude and variability of nyctemeral changes of 17-O.H.P. as well as A.C.T.H. activities do not allow to use these two dosages for a precise supervision of therapeutic effects. On the contrary, the dosage of testosterone allows the appreciation of the risk of virilization and its reliability gives a precise control of the effects of steroid therapy. The dosage of the renine activity disclosed unknown or not well controlled sodium-losses, and allowed to adjust the dosage of 9-alpha-fluorohydro-cortisone, while limiting glucocorticosteroids. It gave also evidence of the usefulness of prolonged steroid therapy until the end of the growth period.

Adolescent↗

PubMedDate not supplied

[Vaginal atresia as a rare cause of a cyst in the fetal lower abdomen. Pre- and postnatal diagnosis/therapy].

This is a report on the course of a cystic mass in the lower abdomen of a female fetus, which could bei seen by prenatal ultrasound. We are describing differential diagnosis, pre- and postnatal therapy and the origin, as well as the risks of vaginal atresia.

Abdomen↗

PubMedDate not supplied

[Zopiclone and delirium: a case report].

Explore the source record for details and available documents.

Ambroxol↗

PubMedDate not supplied

[Nitroglycerin for intraoperative uterus relaxation in cesarean section. Results of a randomized clinical study].

Between June 1994 and July 1996, a prospective, randomized, double-blind clinical study was carried out on 97 patients scheduled for elective cesarean section under general anesthesia at the gynecology departments of the Virchow and Charité Hospitals (both university hospitals of the Humboldt University, Berlin) in order to test the efficacy of glycerol nitrate (GTN: syn.: nitroglycerin) as an intraoperative short-acting tocolytic agent to ease fetal extraction in cesarean section in comparison to a placebo. At the time of the uterine puncture incision, either 0.25 mg (n = 32 patients) or 0.5 mg (n = 34) of GTN or physiological saline (n = 31) was administered as an intravenous bolus. Maternal and fetal pulse rates and blood pressures were closely monitored. The authors developed a scale to evaluate the degree of decrease in uterine tone and the ease of fetal extraction. The statistical evaluation of these estimations revealed no significant easing of fetal extraction and no significant increase in the reduction of uterine tone after administration of both GTN dosages in comparison to the administration of placebo (p > 0.01). Easing of fetal extraction cannot be achieved with the administration of 0.25 or 0.5 mg GTN, at least not in elective cesarean sections of greater than 34 weeks of gestation.

Adult↗