Search PubMed⌕ Search

Biomedical subjects

M David

Publications and source records attributed to M David.

At least 847 records · Page 47Linked to original sources
PubMedDate not supplied

[Orthodontic appliances in the treatment of sleep apnea: a cephalometric and polysomnographic study].

AIM: Effects of oral appliances on snoring in patients with obstructive sleep apnoea syndrome: correlation between cephalometry with and without oral appliance (OA) in place. SUBJECTS: 15 patients were treated with 3 types of OA: Herbst, tooth positioner and QuietKnight. METHODS: All patients underwent a full-night diagnostic polysomnography. They were asked to use their OA each night during one month. All the subjects then underwent a second polysomnography with the OA in place. Standard cephalometric analysis was done in each patient with and without the OA in place. RESULTS: Although average apnea-hypopnea index decreased significantly, snoring was not affected by the OA. Only in 7 patients a reduction was observed. There was a strong correlation between the change in snoring index during sleep and 2 cephalometric variables: ANB angle without, and overjet with the OA in place. No change in quality of sleep was observed. CONCLUSION: OA are indeed effective in decreasing the number of obstructive apneas and hypopneas, without affecting the quality of sleep. Snoring reduction with OA may be predicted by cephalometry.

Analysis of Variance↗
PubMedDate not supplied

In vitro evaluation of lingering antimycotic effect of 2% miconazole nitrate cream (citaderm) on human skin.

An evaluation of lingering antimycotic effect of miconazole nitrate cream 2% was evaluated on the skin of 20-healthy subjects (16 male and 4 female) after a single dose of application. The test spots were covered with bandage. The tape strippings were taken at various intervals of time from the test area, and applied on the agar surface which was priorly inoculated with Trichophyton mentagrophytes isolated from a patient with the symptoms of onychomycosis. The lingering effect of miconazole nitrate was determined by the degree of inhibition of growth of the fungus under the tape. The test drug showed lingering effect from 36 to 48 hours.

Adult↗
PubMedDate not supplied

[Multicenter prospective study of cardiac accidents during treatments with 5-FU].

In a prospective, multicenter study, we evaluated the incidence of adverse cardiac effects in 1097 patients receiving 5-FU as a short i.v. perfusion or as a continuous perfusion over 3 to 5 days. There were 29 cardiac events (incidence 1.6%; 4.5% in patients with a history of cardiovascular disease, 1.1% in the remainder). Adverse effects were more frequent in the patients with advanced WHO (WHO = OMS) stage (2 or 3) primary tumors of the upper respiratory or digestive tract, or of the gastrointestinal tract, when 5-FU was given as a continuous perfusion. They also appeared to be more frequent in patients with a history of cardiovascular disease, and mainly occurred during the second or third day of the first course of treatment. Retreatment of eight patients with 5-FU led to the recurrence of symptoms in five. The outcome of these adverse cardiac effects was generally favorable, but 11.5% of the patients died.

Fluorouracil↗
PubMedDate not supplied

Epizootiological investigation of an outbreak of pullorum disease in an integrated broiler operation.

An integrated broiler company experienced a major outbreak of pullorum disease during 1990. The outbreak resulted in the distribution of Salmonella pullorum-infected birds to more than 150 roaster flocks in five states. Twenty-two parent (multiplier) breeder flocks became infected. An epizootiological investigation uncovered a grandparent male line breeder flock as the index flock supplying males to the affected parent flocks. Transmission apparently occurred vertically through the egg and horizontally by contact in the hatcheries and by placement of chicks on contaminated litter.

Animals↗
PubMedDate not supplied

[What complementary examinations to demand in chronic venous insufficiency?].

The diagnosis of chronic venous insufficiency (CVI) is first of all a clinical diagnosis. Subsequent investigations are useful to elucidate the underlying abnormalities in the venous system and to quantify their severity. Continuous wave doppler ultrasound is the basis test. Duplex scanning is useful for the study of popliteal and tibial veins reflux. The others non invasive techniques aim to investigate patients with severe CVI. But it seems necessary to be very careful with the methodologies used with these tests, and there is a need for a test of the whole calf venous pump function. Venographic studies are performed only if it is necessary to complete the non invasive tests data, before surgical treatment of a postthrombotic syndrome or of congenital deep venous reflux, or when a rare form of CVI is suspected. Venography remains the better test for the study of the anatomy of the venous system, but it is no longer the gold standard for the investigation of CVI.

Chronic Disease↗