Search PubMed⌕ Search

Biomedical subjects

M David

Publications and source records attributed to M David.

At least 649 records · Page 36Linked to original sources
PubMed1980

B and T lymphocytes in lymphoproliferative diseases of the skin. Effect of a thymic hormone on the immunocompetence of T lymphocytes.

Cell-mediated immunity using the E-rosette technique, the graft-versus-host reaction and intradermal skin tests were investigated in two groups of patients, twenty-two with benign lymphoproliferative diseases of the skin (lymphocytic infiltration of the skin and lymphadenosis benigna cutis) and nine with malignant lymphoproliferative diseases (mycosis fungoides and lymphoma cutis). The effect of thymic hormone upon T lymphocytes which proved to have impaired functional capacity was investigated. Seventeen of the twenty-two patients with benign lymphoproliferative diseases were found to have intact cellular immunity whereas seven of the nine patients with malignant disease proved to be immunodeficient. The determination of immune competence may be of help in establishing the correct diagnosis in doubtful cases and might also be useful in the follow-up of these patients. The improvement in functional capacity of T lymphocytes resulting from their interaction with a thymic hormone indicates that it holds therapeutic promise.

Adult↗
PubMed1980

Vitiligo and the HLA system.

77 Vitiligo patients were investigated for their HLA phenotype. Analysis of this material according to age of onset and ethnic origin revealed some significant characteristics. Young Jewish Moroccan patients showed a high frequency of B13 when compared to matching controls. Young patients of Yemenite origin had a strikingly high frequency of BW35. Jewish Yemenites showed a lack of B13 both in patients and in controls. It is suggested that studies by undertaken to clarify this problem further.

Age Factors↗
PubMed1980

Kinetics of the HCG-induced steroidogenic response of the human testis. III. Studies in children of the plasma levels of testosterone and HCG: rationale for testicular stimulation test.

Little information is available regarding the time, rhythm, number, and appropriate dosage of human chorionic gonadotropin (HCG) for adequate testing of testicular function in human. The time course of the effect of two, three, or seven HCG injections at intervals of one, five, and two days, respectively, on the plasma levels of testosterone was studied in 11 boys. The first injection induced a progressive and modest rise of T. The second given one day later had little additive effect, maximal values being seen 72 to 120 hr later. In the prepubertal boys to whom several HCG injections were given, testosterone levels reached comparable levels after four injections every five days or seven injections every other day. Although the number of subjects studied was relatively small, these results give some rational basis for the following HCG test: two or four injections at four-day intervals.

Child↗
PubMed1980

[XY pure gonadal dysgenesis. Two cases report (author's transl)].

Two cases of XY dysgenesis are reported. In one case, that of a 13 year-old girl presenting with impuberism, a gonadoblastoma was detected by histologic examination of the streak. In the second case, that of a 6 month-old girl, short stature and dysplasia of the nails suggested the diagnosis.

Adolescent↗
PubMed1980

[Puberty in congenital hypothyroidism (author's transl)].

Puberty was studied in 95 patients with congenital hypothyroidism treated between 1953 and 1977 from the first months or first year of life. Pubertal abnormalities were observed in 13 cases: 1. Delayed puberty in 11 cases (late diagnosis in 6 cases, insufficient treatment in 2 cases, delayed puberty in the family in 1 case). 2. An amenorrhea-galactorrhea syndrome was observed in two cases with insufficient treatment. In the other cases, the outcome of puberty seemed within the normal range. However a careful study showed: 1st. A delay of every stage of puberty, 2nd. The absence of the peak of high velocity in some cases. 3rd. The age of menarche was 13 years 8 months (9 years 1 month-16 years 6 months) (normal girls: 13 years). Final height was dependent upon an early and efficient treatment, and upon a fast catch up of growth and bone maturation.

Adolescent↗
PubMed1979

[Inappropriate secretion of antiduiuretic hormone during acute leukaemia treated with vincristine. Two cases (author's transl)].

One the basis of two special typical cases, the authors detail the symptoms and signs and consider the physiopathology of inappropriate secretion of antidiuretic hormone related to vincristine. Urinary ADH was measured in both cases. ADH levels could be studied on ten consecutive occasions during the course of one of the cases (obs. n 1). Eleven similar cases have been found in the literature. ADH was measured in only three of them. Methods of treatment are considered, with particular emphasis on the role of demeclocycline.

Child↗
PubMed1979

[Bartter's syndrome: the long term effects of indomethacin on growth (author's transl)].

Six children with Bartter's syndrome aged 6 years 4 months to 13 years 11 months were treated with indomethacin (1.7 to 4.3 mg/kg/day) during 7 to 27 months. A catch up growth was first observed, then growth curve was parallel to the normal. A catch up weight was also observed. The osseous maturation was the faster it was more delayed. These changes were observed despite a partial correction of potassium and plasma renine activity.

Adolescent↗
PubMed1979

[The effect of chloramphenicol on sleep in cat -- comparison with thiamphenicol, erythromycine, and oxytetracycline (author's transl)].

The effects of various antibiotics, which inhibit protein synthesis, has been studied on the sleep-waking cycle of cats. Chloramphenicol (CAP) selectively inhibits paradoxical sleep (SP). Thiamphenicol (TAP) and oxytetracycline however are ineffective; erythromycine induces only a small decrease of SP. When CAP is injected after TAP, the SP inhibition is longer than after CAP alone. Combining erythromycine and CAP produces the same effect as one or other of the antibiotic alone, depending only on the interval between administration of the two drugs. Slow wave sleep is decreased only with high doses of CAP and is unaffected by TAP, oxytetracycline or erythromycine. These results suggest that CAP may inhibit a peptide or protein synthesis involved in the mechanisms of SP.

Animals↗