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M D Altschule

Publications and source records attributed to M D Altschule.

At least 37 records · Page 2Linked to original sources
PubMed1986

Lady's heart.

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Adult↗
PubMed1986

Human plasma lipofuscin melanins formed from tryptophan metabolites.

Incubation of human plasma with the tryptophan metabolites 3-hydroxy-DL-kynurenine (3HK) or 3-hydroxyanthranilic acid (3HAA) yields soluble brown pigments with the fluorescence spectrophotometric and paper chromatographic properties of plasma lipofuscin (PL). An alternative to the recognized tyrosine pathway of melanogenesis is therefore demonstrated in human plasma.

3-Hydroxyanthranilic Acid↗
PubMed1986

Increase in plasma volume after the transfusion of washed erythrocytes.

During a four day period, each of 14 healthy mongrel dogs that had splenectomy was twice bled 450 milliliters of blood and twice reinfused with 500 milliliters of isotonic sodium chloride solution. On the sixth day, the dogs were hypovolemic and anemic; they had 10 per cent reductions in total blood volume and 50 per cent reductions in erythrocyte volume, but no change in plasma volume. Seven of the dogs were transfused with autologous washed erythrocyte concentrates and seven others with an equal volume of autologous plasma. Two units of autologous washed erythrocyte concentrations with hematocrit values of 80 volumes per cent increased plasma volumes to levels similar to those achieved with 2 units of autologous plasma. The serum oncotic pressure, total protein and albumin concentrations were similar in the two groups, except that, two hours after transfusion, the serum albumin level was significantly higher in the dogs transfused with plasma. These data demonstrate that erythrocyte transfusions increase both the erythrocyte and plasma volumes.

Animals↗
PubMed1985

Increase in plasma lipofuscin levels of stored blood.

Venous blood samples from Caucasian men, collected in citrate-phosphate-dextrose anticoagulant and stored in plastic or in glass containers for 10-, 20- and 30-day periods at 4 degrees C, showed increasing levels of plasma lipofuscin (PL) substances. These levels were measured as the intensities of the 340-nm excitation maximum and the 440-nm fluorescence maximum of PL, using a fluorescence spectrophotometer. No increase in PL level was observed in plasma samples separated before storage. These observations suggest that the free-radical activity of PL substances may confer toxic properties to stored blood used in large transfusions, and that stored blood may lose part of its osmotic, hemostatic, immunologic, and other physiologic functions as more plasma proteins are converted into lipofuscin.

Adult↗