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Biomedical subjects

M Crespo

Publications and source records attributed to M Crespo.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Schönlein-Henoch syndrome: review of a series of 142 cases].

Clinical and laboratory findings in 142 children with Schönlein-Henoch syndrome are studied. The children were diagnosed during a ten-year period (1974-1984). Purpura, as more significant clinical finding, was observed in all patients, followed by articular signs (61.2%), abdominal complaints (57.7%), renal signs (30.2%) and testicular (4.2%). IgA, IgG, IgM, complement and cryoglobulin alterations, are remarkable factors to assume an immunologic origin for the syndrome.

Child↗
PubMed1984

[C-reactive protein--determined by radial immunodiffusion and compared to the latex agglutination method].

C-reactive protein were assayed both with immunodiffusion and precipitation on latex C-reactive protein in 216 samples of sera from newborns with suspected septicemia. Both methods correlated well (r = 0.92) rendering the second one rather useful for early diagnosis of neonatal sepsis, since it produces results within a few minutes independent of complicated apparatus or trained personal.

C-Reactive Protein↗
PubMed1984

[Nemaline myopathy: apropos of a case].

Authors present a girl without familiar antecedents of consanguinity with mild motor deficiency, hypotonicity and obesity during infancy, with progressive posterior healing. The girl did not present Marfan's habit or special phenotype, and had small hypertrophy of calfs. There was not recurrent respiratory infections. EMG was myopathic and muscle dependent seric enzymes (CPK, ALD, LDH...) were normal. Radiographically films showed increased relationship fat-muscle and pathology by MO and ME confirmed the presence of small sticks in muscle fibers. After evaluating the case as a neomutation, the genetic counseling is made.

Biopsy↗
PubMed1983

[The value of C-reactive protein in the diagnosis of acute pneumopathies in children].

We have studied 164 children with pneumopathy, ranging from one month to 8 years old. They were classified in two groups according as clinical, biological and radiological criteria. Group I (probable bacterial etiology), 65 children; group II (presumable nonbacterial cause), 35 patients. An indeterminate pattern, 64 infants. The CRP was quantified by radial immunodiffusion method. In the group II, lowest CRP values (less than 30 micrograms/ml) were detected in 86% of the patients. In the group I, 88% of the cases offered values over 30 micrograms/ml. The CRP was a sensitive indicator of diagnosis of pneumopathies in children. High CRP values (greater than 30 micrograms/ml) are suggestive of a bacterial etiology, with statistical significance (p less than 0,001).

Acute Disease↗
PubMed1982

Modification in the pharmacokinetics of amikacin during development.

The disposition kinetics of a single i.v. dose of amikacin was studied in 6 neonates (6-25 days old), 10 infants (4-18 months) and 8 young children (3-11 years). There was a progressive change in the distribution and elimination kinetics during development. The distribution coefficient of the antibiotic averaged of 0.429, 0.320 and 0.210 l/kg in the newborns, infants and young children, respectively and serum half-life (t1/2 beta) in these three groups averaged 2.812, 1.803 and 1.196 h, respectively. Significant differences in certain pharmacokinetic parameters were found between the values in paediatric patients and in adults receiving the same dose. A linear relationship was established between the distribution volume of the antibiotic and the weight of the patients, as defined by the following equation: Vdss (1) = 0.976 + 0.140 . TBW (kg); r = 0.954. The results suggest that a regimen of very frequent administrations should be employed in infants and young children in order to maintain a therapeutic level throughout treatment.

Aging↗
PubMed1982

[C-reactive protein and orosomucoid as parameters of developmental monitoring and therapeutic effectiveness in neonatal sepsis].

Authors develop a comparative study of two acute phase reactants behaviour, in the follow up on 27 neonates with confirmed sepsis of favourable evolution and in 15 cases with fatal evolution. Results show that sera levels C-reactive-protein follow a parallel course with clinical significance in patients reaching normal concentrations soon after favourable evolution and persisting in high level or even increasing previous ones, in cases of lethal evolution. Orosomucoid did show the same clinical-biological correlation maintaining generally in high levels independent of normalization of symptoms and C-reactive protein. They propose serial determination of C-reactive-protein and an efficient control of treatment in neonatal sepsis.

Anti-Bacterial Agents↗
PubMed1981

Pharmacokinetics of amikacin in children with normal and impaired renal function.

The pharmacokinetics of the antibiotic amikacin sulfate were studied in eight children with normal renal function and in ten children with varying degrees of renal impairment. All patients received a single i.v. dose of 7.5 mg/kg of the antibiotic. Amikacin follows a two-compartment open-kinetic model. The serum half-life, which in children with normal renal function has an average value of 1 hour, reached values of 14 hours in children with severe renal impairment. A lineal relationship is established between the beta constant and the creatinine clearance (Clcr) according to the equation beta = 0.001 + 0.005.Clcr, with r = 0,818. From thie equation, the dosage interval is modified to maintain the serum concentrations of the antibiotic within the therapeutic interval.

Amikacin↗
PubMed1980

[C reactive protein as a standard of efficience in antiinfectious therapy (author's transl)].

C reactive protein (CRP) levels are sequencially settled in 58 children, divided in three groups in dependence of their illness: acute bacterial pneumopathy, acute pyelonephritis or neonatal sepsis, all of them receiving antibiotic treatment. CRP values are compared with clinical, radiologic and bacteriologic findings, showing in patients of the first two groups a normalization between fourth and ninth day of treatment, together with clinical and radiologic improvement. In contrast, it was shown that normalization of CRP in neonatal sepsis group was quite slow related to the torpid evolution. The sequentially measure of CRP was prove useful as antibiotic treatment control in children affected with different infectious pictures.

Anti-Bacterial Agents↗
PubMed1980

[Diagnostic value of C reactive protein in neonatal sepsis (author's transl)].

Seric levels of C reactive protein (C.R.P.) were determined in a series of 125 children under one month old. Of them, 75 were clinically healthy and 50 showed signs that suggested infection. In all this infants, in addition to C.R.P., different components of white blood cell differential count were determined, and a bacteriological study was undergone. Authors found high concentration of C.R.P. in 100% of children in which diagnosis of sepsis was bacteriologically confirmed. On the other hand, concentrations of this biological parameter were not substantially modified in newborns used in the control, nor in those other ones in which sepsis was not confirmed. Sensibility of C.R.P. showed itself significantly higher than other hematological indexes in study.

Bacterial Infections↗
PubMed1980

[Karyotype in GPG bands: description of a elementaly technique for routine (author's transl)].

A new technic for banded chromosomes, with similar results (100%) to those obtained with chromatids modification by trypsin (G bands), is described. The key consists in Pyronin addition (20 mg.%) to distilled water at hypotonic shock, following then a standard karyotype technic assayed with micro-method, reaching banding after Giemsa tinction at 3% in 6.7 phosphate pH. Its interest radicates in chromosome modification in vivo, simplicity, fiability (80% of excellent results) and reproductibility, allowing any cytogenetic laboratory a routine obtention of G bands in only four days.

Azure Stains↗