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Biomedical subjects

M Corazza

Publications and source records attributed to M Corazza.

At least 55 records · Page 3Linked to original sources
PubMed1997

Generalized lichen nitidus with oral and nail involvement in a child.

The generalized form of lichen nitidus (LN) with oral and nail changes is extremely rare in childhood. We report a 10-year-old boy with generalized LN associated with oral involvement and onychodystrophy. Oral lesions showed yellowish papules on the gums. The nails had longitudinal striations and pits on the finger-nails, and transversal ridging of the big toes was found. Cutaneous and mucosal lesions as well as onychodystrophy spontaneously cleared within 8 months.

Child↗
PubMed1996

Burning mouth syndrome: the role of contact hypersensitivity.

The burning mouth syndrome is characterized by an unpleasant sensation of burning in the oral cavity, without clinical signs. Causal factors may be psychogenic, systemic or local. The aim of the study was to determine the significance of contact allergy in the pathogenesis of burning mouth syndrome. Fifteen patients with burning mouth syndrome were studied through anamnesis and laboratory analysis. Epicutaneous patch tests were performed with the Italian standard series (GIRDCA - Gruppo Italiano di Ricerca Dermatiti da Contatto ed Ambientali), preservative and dental series. The same tests were carried out in 12 healthy age- and sex-matched subjects. The number of patients affected by burning mouth syndrome with a positive reaction to patchtesting was 6 out of 15, while the number of allergic patients in the control group was 3 out of 12. No association could be found between positive reaction at patchtesting and exposure to allergens. Contact allergy in burning mouth syndrome seems not to play a primary role; nevertheless, it is advisable to perform patch tests in selected patients to identify a possible aetiological agent.

Aged↗
PubMed1996

[The methods of using the echocardiogram in outpatients. The role of the cardiologist for more appropriate use of the procedure. The Ligurian Group of the Italian Society of Cardiovascular Echocardiography].

Concerns about the increasing medical care costs are causing the medical community to focus its attention on the appropriate of diagnostic tests such as echocardiography. Prerequisite to a better utilization of the limited economic resources assigned to our health care system is an analysis of how, why, and with which results diagnostic tests with a widespread use and relevant cost, like echocardiography, are requested. During the last 2 weeks of September 1994, a transversal, observational study was carried out at 13 hospital echocardiographic laboratories. Ordering physician characteristics, reasons for ordering the test, cardiological diagnostic tests previously performed and their relationship with the test results, were evaluated with a questionnaire completed by the physician who performed the test, in all the out-patients undergoing echocardiogram in that fortnight. Five hundred and sixteen consecutive questionnaires were successfully completed. Fourty-five percent of the echocardiograms were ordered by cardiologists, 35% by general practitioners, 10% by internists, and 10% by other specialists. Hypertension (16.4%) and ischemic heart disease (14.8%) were the most common indications for the test, followed by palpitations or arrhythmias (7.5%), mitral valve prolapse or mitral valve disease (7.3%), chest pain or angina pectoris (6.3%), cardiac murmur (5.5%), dyspnea or heart failure (5.2%), aortic valve disease (5%), prosthetic heart valve evaluation (4.6%), others (27%). Before undergoing the echocardiogram, 433 (84%) patients underwent an electrocardiogram, 242 (47%) a cardiological clinical evaluation, 196 (38%) a chest X-ray, and 191 (37%) had had a previous echocardiogram. The most common echocardiographic diagnosis was normal (29.2%) followed by hypertensive heart disease (16.2%), mitral valve disease (12.3%), aortic valve disease (10.5%), ischemic heart disease (9.3%), cardiomyopathy (4.9%) normal prosthetic heart valve function (4.5%), pericardial effusion (3.8%), others (11.3%). Among the echocardiograms ordered by cardiologists, 21.8% were normal in comparison with 35.4% of those ordered by general practitioners (p < 0.004), 35.3% of those ordered by internists (p = 0.04), 35.3% of those ordered by other specialists (p = 0.04). Among the 284 patients whose echocardiograms were not requested by a cardiologist, only 215 (76%) had undergone an electrocardiogram and only 68 (24%) a clinical evaluation by a cardiologist. In these patients, the frequency of normal echocardiograms was not influenced by having undergone a previous electrocardiogram or a chest X-ray. Conversely, patients in whom the echocardiogram was ordered after a cardiology consult showed a significant lower frequency of normal results compared to patients not evaluated by a cardiologist (23% vs 39%; p < 0.05). More than 50% of the echocardiograms performed in out-patients are ordered by physicians who are not cardiologists. Among these echocardiograms, about 1 out of 3 results normal. This finding suggests an improper use of echocardiogram as a screening tool by non-cardiologists in out-patients. A preceding clinical evaluation by a cardiologist, but not an electrocardiogram or a chest X-ray alone, may determine a more appropriate use of the test being associated with a reduced frequency of normal results.

Cardiology↗
PubMed1995

Open study of topical 0.025% tretinoin in the treatment of vulvar lichen sclerosus. One year of therapy.

OBJECTIVE: To study the use of topical tretinoin for treating vulvar lichen sclerosus. STUDY DESIGN: An open, uncontrolled clinical study on 22 patients affected by histologically confirmed vulvar lichen sclerosus. Topical 0.025% tretinoin was applied once a day, five days a week, for one year. Clinical and histologic parameters were evaluated before and after therapy, and statistical analysis was performed. RESULTS: Symptoms, gross appearance and histopathologic features improved in a highly significant manner (P < .001). Cutaneous side effects were observed but rapidly disappeared, and no patient left the study for this reason. Maintenance of results was observed at the 4-13-month follow-up visits. CONCLUSION: Topical tretinoin seems feasible for use in the topical treatment of vulvar lichen sclerosus.

Administration, Topical↗
PubMed1994

Urinary alpha-amylase and serum macroamylase activities in dogs with proteinuria.

Activities of urinary alpha-amylase and serum macroamylase; concentrations of serum creatinine, immunocomplexes, and urinary protein; and patterns of proteinuria were determined in 35 dogs with proteinuria. Urinary alpha-amylase activity ranged from 37 to 4,031 U/L. Macroamylasemia was detected in 77.14% of dogs and the percentage of alpha-amylase precipitated ranged from 4.68 to 61.63. Serum alpha-amylase activity after immunoglobulin precipitation ranged from 654 to 6,390 U/L in 51.42% of the dogs; the values were higher than the reference limits. Concentrations of serum creatinine and immunocomplexes were higher than reference limits for 25.71 and 60% of dogs, respectively. Urinary protein concentrations ranged from 0.1 to 8.9 g/L. All the patterns of proteinuria were represented. Linear regression indicated correlations between urinary alpha-amylase activities, serum creatinine concentrations (P < 0.01), and concentration of immunocomplexes (P < 0.05). Mann-Whitney test indicated significantly higher urinary alpha-amylase activity (P < 0.01) and percentage of alpha-amylase precipitated (P < 0.05) in dogs with renal insufficiency.

Amylases↗
PubMed1994

Crohn's disease of the vulva. A case report.

A rare case of vulvar Crohn's disease occurred in a 43-year-old woman who presented with a monolateral plaque on the vulva with a granulomatous histologic pattern. The problem of distinguishing Crohn's granuloma from other granulomatous lesions is underlined.

Adult↗