Biomedical subjects

M Cojocaru

Publications and source records attributed to M Cojocaru.

61 records · Page 4Linked to original sources

PubMedDate not supplied

Demonstration of the neutrophil granulocyte functional capacity in silicosis, using the NBT test.

The functional capacity of neutrophils was studied using the NBT test in 68 patients with silicosis in various evolutive stages, comparatively with a group of 35 controls. The NBT test showed an initial increase of nonspecific cellular reactivity which decreased as the disease evolved. The results in the control group showed 9 +/- 5% NBT positive neutrophils. The highest proportion of NBT positive neutrophils (17.6 +/- 2.3, p < or = 0.05) was found in stage I of the disease and then decreased gradually with the evolution of the disease. The proportion of NBT positive neutrophils may be considered as a biochemical marker of neutrophil functionality.

Biomarkers↗

PubMedDate not supplied

Study of lung antibodies in patients with silicosis.

The presence of lung antibodies was determined in a group of 68 patients with silicosis in various stages of evolution and in a control group of 35 healthy subjects, by the standard indirect immunofluorescent technique with fluorescent conjugate anti human gammaglobulin and monospecific fluorescent conjugates anti human IgG, IgA and IgM. In the group of patients investigated, lung antibodies were detected by means of fluorescent conjugate anti human gammaglobulin, in 47 cases of the 68 examined. As regards the investigations using monospecific fluorescent conjugates it was observed that all the 47 patients presented lung antibodies of the IgG class, 32 presented lung antibodies of the IgA class and 15 presented lung antibodies of the IgM class. The presence of lung antibodies in silicotic patients suggests the participation of acquired humoral immunity in the pathogeny of disease without, however, being directly responsible for the evolution of disease. The association of silicosis with various other autoimmune diseases pleads for the existence of an immune component in the evolution of this pneumoconiosis.

Autoantibodies↗

PubMedDate not supplied

Changes of some parameters of humoral and cellular immunity in allergy to pollen.

The study of some parameters of humoral and cellular immunity in 45 pollinosis patients and 18 healthy controls, showed a deficit of humoral immunity reflected in a decrease of the IgA and IgG mean values and an increase of the IgM mean values (coefficient of correlation (r): r IgA/IgG = 0.912; r IgM/IgG = -0.316). As regards the cellular immunity the study revealed both a numeric and a functional decrease of the T lymphocytes r Th/Ts = -0.877, showing a deficit of cellular-mediated immunity.

Adult↗

PubMedDate not supplied

Antineutrophil cytoplasm antibodies in patients with silicosis.

The presence of antineutrophil cytoplasm antibodies (ANCA) was followed up in silicosis with or without renal involvement. From the 68 patients with silicosis, 5 presented renal involvement. Of these 3 showed the presence of pANCA. The other 63 patients without renal involvement presented cANCA only in 2 cases. The control group showed no presence of ANCA. The incidence of ANCA in silicosis with renal involvement was discussed in view of an eventual elucidation of the pathogenesis of this disease, which was frequently associated with autoimmunity diseases.

Antibodies, Antineutrophil Cytoplasmic↗

PubMedDate not supplied

[Pell-Nicol, a medicinal toothpaste].

A medicinal toothpaste based on an atomized extract obtained out of sulfurous mud of Nicolina Iassy (a natural organic-mineral complex) has been formulated and physico-chemically characterized. The optimal formula has been chosen corresponding to following parameters: aspect, colour, taste, smell; weight/tube (65 g +/- 5%); Dentine Abrasion Value (D. A. V.) = 30; pH = 6.95-7.42; foaming capability of foam, in minutes = 0.40-0.60; residue on the sieve (g% = 0.09); heavy metals content; abrasive substances; g% = 32-37 at least; sodium chloride g% = 0.30 at least; firmness time = 30 sec. Also it have been effectuated rheological measurements and dynamic viscosity. The medicinal toothpaste Pell-Nicole presents a plastic behaviour with thixotropic character, which confers a good stability in time, an adequate firmness and comparable properties with others marketed products. The therapeutical effects have been tested, such as the antimicrobial and anti-inflammatory actions. The medicinal dentifrice toothpaste Pell-Nicole is recommended for gum affections, superficial chronic inflammatory forms, deep paradontopathies, as well as for a proper dental hygiene.

Administration, Topical↗

PubMedDate not supplied

[The clinico-epidemiological premises for antioxidant prevention and treatment in chronic myocardial infarct].

The improvement of therapeutic and recoverable proceeding to chronic myocardial infarction (IMC) imposes a complex epidemiological estimation of the global cardiovascular risk, of their clinical and biological status. The retrospective evaluation of the risk factors (RF) by epidemiological methods, in 38 hospitalized prevalence of both constitutional and behavioral factors, and the quantification of the risk state, according to graph Euro 194, has pointed on the fact that 50% of IMC cases have presented a global risk of 10-20%. That justified the application of a preventive conduct in order to continually neutralize the associates FR. The biochemical determinations have allowed to frame the dyslipidemic patients, according to the ARCOL classification in the classes D (29.2%), E (25.0%) and B (20.8%) with direct implication in the adopted therapy. The colorimetric dozing with thyo-barbituric acid of the malonly dialdehyde (MAD) each is a product of the lipidic peroxidation, as well as the interpreting or correlation of the registered values with an evolutive clinic stage, and with the existence of some existing diseases (diabetes, chronic hepatitis etc.) along with signification of other dismethabolical parameters (cholesterol, triglycerides, LDLc, apoB) have confirmed the necessity of a complex therapy, including an antioxidative treatment, having the role to directly inhibit or exclude the free radicals resulted after the oxidative stress of the infarct.

Antioxidants↗

PubMedDate not supplied

Relationship between serum total sialic acid and C-reactive protein in silicosis.

Serum total sialic acid and C-reactive protein (CRP) were studied in 68 patients with silicosis divided into 3 groups according to the evolutive stage of disease. The results were compared with the data obtained in a control group of 35 healthy subjects. The changes in serum total sialic acid levels were in parallel with those of CRP in silicosis. Patients in stage III had the highest mean values of serum total sialic acid (p < 0.01) and of CRP (p < 0.001). Linear regression analysis revealed a close positive correlation between serum total sialic acid and CRP levels in silicosis (r = 0.86, p < 0.01).

Adult↗