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Biomedical subjects

M Cojocaru

Publications and source records attributed to M Cojocaru.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

The variations of the serum IgD and of the circulant immune complexes in diabetic patients.

The levels of serum IgD and of the circulating immune complexes (CIC) were determined in 168 diabetic patients, of whom 78 with type 1, 59 with type 2 and 31 with the so-called "intermediary" type of the disease, in comparison with 124 non-diabetic subjects for IgD and 100 for CIC. The results revealed very low IgD titres (less than 1 mg%, considered undetectable) in almost 3/4 of the cases; values over 1 mg% were recorded mostly in the cases of type 1, followed by those of "intermediary" and of type 2 diabetes. The mean CIC values of 67.13 +/- 36.53 optic density units (O.D.U.) were significantly higher than in the non-diabetic controls. Certain differences with respect to age, diabetes type, duration of the disease and of the insulin therapy were also recorded. The data are interpreted with caution, further investigations being necessary to the assertion of definite conclusions.

Adult↗
PubMedDate not supplied

Study of anti-striational and anti-thyroid antibodies in patients with myasthenia gravis.

The study was carried out in 74 patients out of whom 46 with generalized myasthenia gravis and 28 with the ocular form of disease--all in acute state, ranging in Osserman's severity scale between I-IV; the age at onset of disease varied between 18-79 years. It showed anti-striational antibodies in 31% of the patients and anti-thyroid antibodies in 40%, as compared with 41 controls. Likewise it was observed that the presence of anti-striational antibodies with significant high values was associated with the presence of thymomas in 16 generalized myasthenia gravis patients and in 3 ocular myasthenia gravis patients (p < 0.001). Anti-thyroid antibodies were more frequently observed in ocular myasthenia gravis (23 cases) as compared to generalized myasthenia gravis (7 cases) with significant high levels (p < 0.001). The results obtained showed that the study of anti-striational antibodies can be of great utility in the diagnosis of thymoma, and that the study of anti-thyroid antibodies can be of great utility to sustain the clinical diagnosis of ocular myasthenia gravis. The presence of anti-striational and of anti-thyroid antibodies showed a basic alteration of immunoregulatory mechanisms of maintaining immune tolerance in myasthenia gravis patients.

Adolescent↗
PubMedDate not supplied

Silicosis related changes in serum copper.

To ascertain the diagnostic and prognostic value of serum copper in silicosis, this trace element was determined in 68 patients (all males), aged varied between 20 and 60 years (mean age 44 +/- 2.3 years). The same determination was carried out in a control group of 35 healthy subjects. The patients were distributed into three subgroups according to the evolutive stage of disease. The mean value of serum copper increased gradually from stage to stage reaching in stage III the highest copper mean value (p < 0.01). Serum copper concentrations also increased with the severity of the disease. These changes suggest that copper is directly responsible for the lung changes in silicosis and can be used as an indicator of the severity of the inflammatory reaction.

Adult↗
PubMedDate not supplied

[Immunologic research in pediatrics].

The child, in his ontogenesis, repeats the phylogenetic evolution of the immune processes. The immunologic maturation gradually appears, the process having a definite duration. The immunologic maturation seems to be parallel to the maturation of other physiological processes. The immune system of the child is different from that of the adult, and the development features of his immune reactivity will give a specific evolution to his morbid manifestations.

Antibody Formation↗
PubMedDate not supplied

The IgD-zinc relationship in patients with allergic bronchial asthma.

In recent years, evidence was brought of the zinc ion (Zn++) interference in the mechanism of certain processes occurring at molecular level, i.e., the protein synthesis, the activity of some enzymatic complexes, the regulation of transmembranal transport or the processes of immune regulation. The present paper investigates the variations of the immunoglobulin classes in patients with bronchial asthma, particularly the relationship between IgD levels and those of the zinc ion in the blood serum.

Allergens↗
PubMedDate not supplied

[Clinical observations of treatment with Lyorodin-depot (Jenapharm)].

According to the indications of fluphenazin decanoate in the long-term treatment in schizophrenia the authors analyse the findings of a simple blind study of Lyorodin-depot on a sample of 20 inpatients. The drug was administered at intervals of 21 days for 18 weeks under clinical surveillance. The method consisted of patients' follow-up on an itemized card, psychological checkups and para-clinical investigations. The analysis of clinical findings reveals the amelioration of symptoms at the parameters accounted for, the favourable evolution low incidence of the side effects that confirms its clinical efficiency and tolerance.

Adult↗
PubMedDate not supplied

Pulmonary involvement in systemic lupus erythematosus.

In the course of an ample study of collagen diseases carried out in the "N. Gh. Lupu" Institute of Internal Medicine--Bucharest over a long period, a group of 608 patients with systemic lupus erythematosus (SLE) hospitalized between 1974 and 1986 formed the object of the present study. Of these patients 18% presented pulmonary alterations due to SLE and 3.9% lung diseases of other etiology. The types of pulmonary involvement due to SLE were: pleurisy, interstitial pneumonia, diaphragmatic myopathy. Latent pulmonary damage could also be diagnosed in 8 patients. Most of the patients (94.1%) were females and had been hospitalized several times. Concomitantly with pulmonary damage other organ involvements have also been observed. Complex investigation of respiratory function performed in a selected group of patients revealed: restrictive syndrome, decrease of the gas transfer factor, increase of elastic recoil, hypoxemia on exercise. In most of the cases (92%) the pulmonary diseases had a chronic evolution. The treatment used was corticosteroids in 60% of the cases investigated.

Adolescent↗
PubMedDate not supplied

Electrophoretogram of lysates deriving from mononuclear cells. Preliminary observation.

Electrophoresis of mononuclear lysates was applied for the first time in the study of the lymphocyte protein content as an additional method beside the rosette test and scanning electron microscopy. The specification of T and B lymphocytes in the presence of discordant results sometimes obtained by the latter methods is facilitated by the additional data supplied by the study of their endoplasmic protein contents. The electfophorogram contributes to a better knowledge of the immunologic status of patients with autoimmune and lymphoproliferative diseases as well as to a more precise determination of the effects following the administration of immunomodulating treatment.

B-Lymphocytes↗
PubMedDate not supplied

The role of infections with Yersinia pseudotuberculosis and Yersinia enterocolitica in the pathogenesis of chronic inflammatory, rheumatic and collagen diseases.

From 50 cases of polyarthritis with febrile onset, 3 were found with serum positive Yersinia pseudotuberculosis (YPT) at a titer higher than 1/100. Reactive polyarthritis with gram-negative germs (YPT) serologic type I, involved in their etiology have been rarely encountered especially in North Europe and in the Far East. Though the 3YPT positive cases mentioned above, presented on admission particularly severe forms of joint inflammation, under therapy with Tetracycline and Phenylbutazone derivatives the articular inflammations were cured without relapses in the 6 months of investigations.

Adolescent↗
PubMedDate not supplied

Influence of pregnancy, birth and abortion on the evolution of systemic lupus erythematosus.

The effect of pregnancy, birth and abortion on systemic lupus erythematosus (SLE) was studied in 225 patients with or without a history of pregnancy and abortion. It was observed that pregnancy, birth and abortion aggravate the evolution of disease in patients with active SLE. The tissue autoantibodies studies presented a low titer in patients in whom pregnancy had occurred in the course of disease. Antimeasles antibodies presented a high titer in patients with a history of gestation. These data suggest that gestation induces immune changes which aggravate SLE.

Abortion, Spontaneous↗
PubMedDate not supplied

The zinc-immunodeficiency relationship in old patients.

The influence of oral zinc sulphate therapy on the humoral immunity was investigated by dosages of serum immunoglobulins (Ig) and of plasma zinc levels in 12 patients with a mean age of 70 years, in comparison with other 11 patients treated with placebo and with a control group of 50 apparently healthy subjects. The results of this double-blind study demonstrated the zinc effect on the immunoregulation, as the Ig levels, and particularly those of the IgG class, initially high, were lowered in a statistically significant proportion. It is assumed that further clinical trials with various zinc concentrations could bring more information on this trace element participation in the humoral immunoregulation.

Aged↗
PubMedDate not supplied

Changes of serum complement and of circulating immune complexes in patients with multiple sclerosis.

The changes of total hemolytic complement (CH50), of C3 and C1q components and of the circulating immune complexes (CIC) were studied in a group of 112 patients with multiple sclerosis (MS) and in 50 controls. The attack was taken as a basis of observation. It was observed that in MS attacks CH50, C3 and C1q were decreased owing to the activation of the complement in the classical way. The CH50 values were found well enough correlated with C3 and C1q (r = 0.535) and respectively r = 0.497) and clearly correlated with the CIC values (r = 0.907). A sharp decrease of CH50 increases the probability of the appearance of an attack with slow remission and the probability of an attack with slow remission is the greater, the greater the increase of CIC values. Low CH50, C3 and C1q values correlated with high CIC values may be considered markers of severity in MS.

Adolescent↗
PubMedDate not supplied

The role of certain immunologic parameters in silicosis.

The paper presents some possibilities of estimating the immunologic aggression in silicosis in a group of 68 patients divided into three subgroups according to the evolutive stage of disease. The results were compared with the data obtained in a control group of 35 clinically healthy subjects not subjected to respiratory noxae. Parameters such as the immunogram (IgG, IgA IgM, IgD), the C3 complement, the circulating immune complexes (CIC) and the C reactive protein (CRP) were investigated using classical immunochemical methods. It was observed that the immunoglobulin titer presented a polyclonal increase. The mean values of C3 complement decreased in stages I and II of disease. The CIC level presented high mean values unrelated to the stage of the disease. The incidence of CRP was found high in stage III. It was demonstrated that there is no significant correlation between the humoral immunologic abnormalities and the radiologic changes or the depression of the pulmonary functional test. These changes suggest that the humoral immunologic abnormalities are not directly responsible for the lung changes in silicosis and cannot be used as a predictive indicator of the severity of the disease or of its progress. The data obtained showed a hyperreactivity of the humoral mediated immunity over the whole course of the disease thus supporting the assumption of an immunopathogenic mechanism in this disease.

Adult↗