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Biomedical subjects

M Clemens

Publications and source records attributed to M Clemens.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Complications following duodenohemipancreatectomy. Results of 112 patients 1974-1983].

From 1974 to 1983, 112 patients were treated at the Chirurgische Universitätsklinik Münster according to the procedure first published by Whipple in 1935. 40 patients (35.7%) were operated for chronic pancreatitis, 39 for (34.8%) ampullary cancer and 33 (29.5%) for pancreatic cancer. As to operative mortality which amounted to 10.7% (12/112) for all patients, figures of 10.0% (4/40) could be found for relapsing pancreatitis and 7.7% or 15.2% respectively for cancer patients. The underlying cause was circulatory arrest in 6 cases, anastomotic leakage in 4 cases, liver failure and gas gangrene in 1 case each. Altogether eight relaparotomies were performed (7.1%). As non-letal complications, pancreatic fistula, rise of liver enzymes, wound healing disturbances, and pleural effusion were the most frequent non-letal complications. By using the Ethibloc for pancreatic duct occlusion the rate of complications could be lowered. Hardly ever, glucose-metabolism was markedly affected by this extensive procedure.

Adult↗
PubMed1984

The influence of paracetamol on the hepatic biosynthesis of lecithin.

In paracetamol induced liver injury changes in the phospholipid components of microsomal membranes are usual. Direct incubation of paracetamol with subcellular fractions of human liver specimens did not alter the biosynthesis of lecithin. Preincubation of liver slices with paracetamol led to an increased synthesis of lecithin. The presence of intact cells and the integrity of hepatocellular function seem to be a prerequisite for the poisoning effects in vitro.

Acetaminophen↗
PubMed1984

[Somatostatin in pancreas and small intestine fistulas].

Infusing 6 mg of somatostatin continuously for 24 hours will lead to a reduction of pancreatic secretion and perfusion of the splanchnic area. Due to this mechanism, secretion is significantly reduced in case of pancreatic or small intestine fistulae. Somatostatin was applied continuously in 39 patients for a period of 7 days. This led to a healing of pancreatic fistulae in 85.7% and small intestine fistulae in 63.6% of cases.

Adult↗
PubMed1984

[Papilla and pancreas cancer. An epidemiologic-clinical case control study of 298 patients].

The study is based on the case records of 816 in-patients (256 adenocarcinoma of the pancreas, 42 carcinoma of Vater's papilla and 518 controls) admitted to the Surgical Clinic of Münster University between 1974 and 1982. With respect to preliminary diseases only pancreatitis and cholecystectomy showed a significant difference between cancer group and control group. 36% of the patients with ampullary and 6.7% with pancreas cancer survived the five-year limit. Prognosis was best among patients over 60.

Adenocarcinoma↗
PubMed1983

[The hip in sickle-cell anemia and its surgical treatment. Apropos of 4 cases].

The authors report 4 cass of hip involvement in sickle-cell anaemia. The patients were aged, 3, 12, 18 and 24 years and presented with the appearances of avascular necrosis of the femoral head. Three had a femoral osteotomy with a good result. A review of the literature was made to determine the pathogenesis, epidemiology and classification into 3 groups. The authors consider that osteotomy acts by diminishing pressure in the area of bone necrosis. The eventual need for total hip replacement is discussed.

Adolescent↗
PubMed1982

[The effect of intraductal duct occlusion with a fast hardening amino acid solution in acute animal experimental pancreatitis].

The effect of the occlusion of the pancreatic duct system by Ethibloc was studied in cases of acute pancreatitis in animal experiments. Application of 4,5 ml Ethibloc leads to high significant reduction of amylase increase. The favourable effect is markedly reduced after application of 9 ml Ethibloc. A partial excretory function could be demonstrated also after disintegration of Ethibloc. Histological follow-up shows a progredient fibrotic atrophy of pancreas parenchyma.

Acute Disease↗
PubMed1982

[Experience with the surgical treatment of peripheral arterial occlusions].

A total of 293 patients were treated 320 times for acute peripheral vascular occlusion. Arterial embolism was most frequent followed by arterial thrombosis and traumatic vascular occlusion. For differential diagnosis other causes had to be considered. The method of choice is extraction of the thrombus by Fogarty catheter or ringstripper. The results depend on the time between occurrence and operative treatment of the occlusion. Angiography is not necessary in a clear case of embolism, but essential when exact preoperative classification of the vascular occlusion is not possible.

Aged↗
PubMed1981

[Pancreatic duct occlusion following duodeno-pancreatectomy in cancer surgery].

In 19 patients with a carcinoma of the pancreas an intraoperative occlusion of the pancreatic duct was performed with a partial duodenopancreatectomy by instillation of Ethibloc. In 13 cases a carcinoma of the papilla and in 6 cases a carcinoma of the head of pancreas were found. In two cases the duct was primarily closed by suture, which was followed by a pancreatic fistula that disappeared after 2 weeks. Therefore, a pancreaticojejunal anastomosis was performed in the other patients. One patient died owing to a total necrosis of the remaining pancreas, but no other local complications were seen at the time of pancreatic anastomosis. Lethality was approximately 5% and was therefore significantly lower than in other reports.

Diatrizoate↗