Search PubMed⌕ Search

Biomedical subjects

M Clarke

Publications and source records attributed to M Clarke.

At least 325 records · Page 18Linked to original sources
PubMed1980

Epidemiological studies of rubella virus in a tropical African community.

The single-radial-haemolysis test for antibody to rubella virus provides a simple rapid method for carrying out large serological surveys. The availability of a collection of sequential serum samples from inhabitants of two Gambian villages, Manduar and Keneba, made it possible to determine the pattern of rubella epidemics in these communities between 1966 and 1976. The serological findings indicated that an epidemic had occurred approximately two years before the commencement of the study. There was no further evidence of rubella infection until approximately 1973 when a large-scale epidemic occurred. Although the communities were monitored throughout the period of study there was no clinical evidence of infection and no cases of congenital rubella syndrome.

Adolescent↗
PubMed1979

Effect of rubella vaccination programme on serological status of young adults in United Kingdom.

Antibody to rubella virus was measured in over 10,000 serum samples collected in 1976, 1977, and 1978 from young adult blood donors and university students. The incidence of seronegatives was lower (4--7%) among females born in 1956 and subsequently--i.e., among the age groups offered rubella vaccine at school--than among females born before 1654 (11--20%). The incidence of seronegatives among males in the 1977 and 1978 surveys had the opposite trend, with a higher proportion of seronegatives in younger males, born in 1956 and subsequently, than in older males. The findings provide evidence that the rubella vaccination programme in the U.K. is having a significant impact on the immunological status of young females of childbearing age. Nevertheless too high a proportion of young females remains potentially susceptible to rubella.

Adolescent↗
PubMed1979

Depression in women after perinatal death.

Post-partum depression was studied with the Beck inventory during a 6-month period in two groups of over 300 women. The difference in prevalence of depression between women who had had live births and women whose babies were stillborn or died in the first 7 days of life was influenced by age. At 6 months, post-partum depression was just as common in women aged under 24 whose babies had survived as in women of the same age whose babies had died.

Adult↗
PubMed1978

Validation of "transit renography" for the determination of the intrarenal distribution of plasma flow: comparison with the microsphere method in the anaesthetized rabbit and pig.

1. The spectrum of transit times of sodium o-iodohippurate (Hippuran) through the kidney can be derived from an 131I- (or 123I-) labelled Hippuran renogram by deconvolution. In the rabbit and pig, as has previously been shown in man, the frequency distribution curve for the transit times was bimodal. Since the transit time is likely to be proportional to the nephron length, the area of the first mode is likely to represent plasma flow to the shorter outer cortical nephrons whereas the delayed mode represents flow to the long juxtamedullary nephrons. 2. This interpretation was tested by simultaneously comparing renography with the microsphere method of measuring intrarenal plasma flow distribution in 12 rabbits and two pigs with a variety of anaesthetics. A close agreement was found between both methods for the percentage of plasma flow distributed to the outer cortical nephrons, thus supporting the use of "transit renography" to determine the intrarenal distribution of plasma flow.

Anesthetics↗
PubMed1977

The use of single-radial-haemolysis for rubella antibody studies.

The use of a single-radial-haemolysis technique for the detection of antibody to rubella virus is described. The single-radial-haemolysis test was compared with the standard HI methods for the detection of antibody to rubella virus. A close correlation between the two methods was observed in a survey of over two thousand serum samples and the study indicated that single-radial-haemolysis was highly satisfactory as an assay method for IgG antibodies to rubella virus. It was found that the immuno-globulins active in SRH tests sedimented in the 7S range in sucrose rate gradients and were presumably immunoglobulins of the IgG class, but 19S immunoglobulins did not produce haemolysis.

Adolescent↗
PubMed1977

Intrarenal distribution of plasma flow in cirrhosis as measured by transit renography: relationship with plasma renin activity, and sodium and water excretion.

1. The intrarenal distribution of plasma flow was determined with a technique based on the analysis of the transit time of sodium o-[131I]- iodohippurate through the kidney in 43 patients with cirrhosis with near-normal total renal perfusion. 2. Twenty-five of the patients had an abnormal pattern of transit times, suggesting a redistribution of plasma flow from outer cortical to juxtamedullary nephrons. 3. Plasma renin activity ranged from below normal to six times normal and high values were found only in patients showing an abnormal pattern of transit times. The latter was also found to be related to sodium retention and a reduced renal capacity to excrete free water.

Adult↗