[Effect of submaximal physical exertion on the activity of various serum enzymes in patients with ischemic heart disease].
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Biomedical subjects
Publications and source records attributed to M Cholewa.
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The investigations were carried out in 50 young healthy men, of whom 20 made an increasing submaximal physical effort on a bicycle ergometer after drinking a 250 ml coffee infusion (20 g of pure natural coffee); the remaining 30 men represented the control group. The left ventricular systolic time intervals (LVSTI) were obtained from polycardiograms by means of the Weissler et al. method. It was found that 20 minutes after coffee drinking the left ventricular ejection time index (LVETI) and LVET/PEP ratio increased whereas the pre-ejection period index (PEPI) and the isovolumic contraction time (ICT) decreased. This improvement of the activity of the heart as a pump which is indirect proof of increased myocardial contractility after drinking coffee was especially noticeable during subsequent phases of physical effort. The recovery period in group 1 was characterized by a reduced PEPI and ICT and increased LVETI and LVETI/PEP ratio as compared with the control group.
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The studies were carried out on thirty-one sportsmen, cyclists aged 21-28 years, after the termination of a training course just before the start of their season. They exercised on a bicycle ergometer according to the following schedule: 30 N at 60 rev/min for 6 min, 40 N at 70 rev/min for 5 min, 50 N at 80 rev/min for 5 min and 50 N at 90 rev/min until exhaustion. According to the level of training the subjects were divided into three groups. In the three groups of cyclists were determined the concentrations of total plasma peptides and their individual fractions obtained by gel-filtration on Sephadex G-10. It was found that the total plasma peptide concentration varied with the level of fitness. The lowest plasma peptide concentration was observed in cyclists with the lowest level of fitness and it differed from those observed in cyclists with intermediary and high levels of fitness. After exercise the biggest increase in plasma peptide concentration was found in the cyclists with the low level of fitness, and the lowest one in those with the high level of fitness. Individual plasma peptide fractions also revealed differences before and after exercise depending on the level of fitness.
The study involved 51 healthy males aged 20 -- 24, divided into two groups. Group I (30 subjects) performed exercise on a cycle ergometer with the load increasing according to the following schedule: 1 W/kg for six minutes, 2 W/kg -- six minutes, and 3 W/kg -- six minutes. The remaining 21 subjects (group II) performed identical exercise one hour after they had been administered 10 mg of diazepam (Relanium-Polfa). The determinations made included arterial blood levels of FFA, triglyceride, and glucose before the exercise, after each successive phase of the exercise, and in the course of restitution (30 minutes and 4 hours after the exercise). One hour after diazepam administration, the FFA, triglyceride and glucose levels decreased. After the successive phases of the exercise, the FFA levels were significantly lower among group II subjects, and continued to be so also in the 30th minute after the exercise. The decrease in the triglyceride levels during the exercise was higher among the diazepam subjects, and they were slightly lower also in the course of restitution. In both groups the glucose levels gradually increased after each phase of the exercise, and the increase after the third phase was higher among the diazepam subjects. During restitution the glucose concentration was higher than before the exercise, and slightly higher in group II.
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35 young, healthy men were divided at random into two groups. Each of them made physical effort of different intensity and different quantity of the work performed. It was found that intraocular pressure was decreased in both groups but its drop was bigger in the group whose work was more strenouos. From the difference of performance of intraocular pressure in both the controlled groups we can conclude the degree of reduction of intraocular pressure and length of its duration may depend on quantity of the work performed. The pulse and blood pressure seem not to affect the intraocular pressure.
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Gastric basal secretion was studied at rest, in the course of one hour's exertion and one hour's restitution in 10 patients with chronic duodenal ulcer, aged 21-52. The subject performed exercise on a Monark ergometer under a load that gave constant pulse rate acceleration equal to 50% of the age-related maximum. Gastric juice samples were collected with the subjects sitting, in three successive phase of rest, exercise, and restitution. It was found that during exercise there was an increase in the gastric juice volume, HCl levels in it, basal secretion volume, and overall sodium, potassium, chloride, calcium, and magnesium content, their concentration in the juice having remained constant. In the course of restitution the above values did not differ in any significant way from those obtained at rest.
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