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Biomedical subjects

M Castillo

Publications and source records attributed to M Castillo.

At least 271 records · Page 15Linked to original sources
PubMed1983

Circadian profiles of blood glucose and plasma free insulin during treatment with semisynthetic and biosynthetic human insulin, and comparison with conventional monocomponent preparations.

Sixteen hospitalized insulin requiring diabetics treated with a single daily subcutaneous injection were randomly allocated either to a mixture of porcine Actrapid + Lente MC or a mixture of Regular + NPH-Biosynthetic human insulin (Study 1). In Study 2, 10 patients receiving two daily insulin injections were treated at random with either porcine Actrapid + Monotard, or Actrapid + Monotard-Semisynthetic human insulin or Regular + NPH--Biosynthetic human insulin. Once an optimal insulin regimen was obtained, circadian blood glucose and plasma free insulin profiles (7-9 time points) were determined with the two (Study 1) or three (Study 2) insulin preparations, keeping the doses of insulin constant. In Study 1 no significant difference in blood glucose (BG) or plasma free insulin (FIRI) profiles was observed. The mean daily blood glucose, the mean amplitude of glycaemic excursions (MAGE), the index of blood glucose control (M-value of Schlichtkrull), as well as the postbreakfast increases in blood glucose and mean free IRI, were similar with both types of insulin. In Study 2, BG and FIRI profiles were also similar, except for a significantly lower (p less than 0.02) BG at 8.30 p.m. with both human insulins. No significant differences were found in free IRI at that time. Mean BG, M index, MAGE and mean FIRI were similar but the postbreakfast increase was significantly smaller with SHI. In conclusion, the pharmacokinetics of animal monocomponent, semisynthetic and biosynthetic human insulin appear similar, but evening BG control was better with both types of human insulins given twice daily.

Blood Glucose↗
PubMed1983

[Kaposi's sarcoma].

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1982

Oxytocin augmentation of dysfunctional labor. I. Clinical data.

The effectiveness of a specific oxytocin dosage regimen and a specific computer-defined initial goal of a contractile activity is compared to groups of similar nulliparous women managed by the same physicians who used their own choices of oxytocin therapy and electronic monitoring of the intrauterine pressure. The patients managed by a specific regimen and a computer-defined therapeutic goal had oxytocin stopped or the dosage reduced because of concerns with fetal distress or, less frequently, hypercontractility, had shorter intervals from the initiation of oxytocin to full dilation, required smaller doses to accomplish cervical change, and received smaller maximum doses of oxytocin. The most significant factor determining these results was the rate of incrementation of the oxytocin dose.

Computers↗
PubMed1982

Inorganic phosphate-insulin relationships in normal subjects and in patients with moderate glucose intolerance.

The relationship between serum insulin and serum inorganic phosphate levels was investigated in normal subjects (NGT) and in patients with moderate impairment of glucose tolerance (IGT1 with subnormal and IGT2 with excessive insulin secretion) fasting and after oral glucose. Insulin and phosphate fasting levels were similar in all groups. In NGT subjects, a significant correlation between fasting insulin and inorganic phosphate levels are observed. In NGT and in IGT1 subjects, oral glucose administration was followed by a fall in serum phosphate level that was well correlated with the total insulin released. The phosphate fall was severely impaired in IGT2 patients, despite the increased insulin secretion. The plasma ionized calcium levels remain unchanged throughout the OGTT. The present results support the hypothesis that in IGT1 patients a reduced glucose-induced insulin release and in IGT2 patients, a peripheral resistance to insulin action could be the determinant of impaired glucose tolerance.

Adult↗
PubMed1981

Neonatal localisation of a sound in visual space.

A tone was played to neonates in one of four conditions: in an unstructured visual field; spatially concordant with a single visual target; spatially discordant with a single visual target; or spatially concordant with one of two identical visual targets at different locations. Auditory-oculomotor spatial coordination, contingent on sound, was enhanced by the presence of a target in the visual field. Audition and vision are mutually supportive in auditory localisation from birth.

Acoustic Stimulation↗
PubMed1980

Massive pulmonary embolism associated with a right ventricular myxoma.

A 12 year old boy had a massive pulmonary embolism associated with a right ventricular myxoma. This caused complete occlusion of the main trunk of the left pulmonary artery and of a branch of the right pulmonary artery supplying the basal area of the lower lobe of the right lung. The patient died despite two surgical attempts to remove the tumor clots. To our knowledge this constitutes the first report of a massive pulmonary artery embolism associated with a right ventricular myxoma.

Child↗
PubMed1979

[Effect of octanoic acid on the insulin secretion in response to glucose in vitro (author's transl)].

The effect of octanoic acid (1.5 mM) on insulin secretion in 4.4 and 16.7 mM glucose stimulation has been studied in rat's isolated and perfused pancreas. The absence of octanoic acid does not produce any significant insulin secretion increase in response to 4.4 mM glucose infusion, whereas its presence produces a significant insulinic response of a monophasic nature. Both in the presence and absence of octanoic acid, the 16.7 mM glucose-stimulation produces a biphasic insulin secretion. The octanoic acid enhances both the first and the second phase of insulin secretion. The present results show that octanoic acid clearly potentiates the insulin secretion in response to 4.4 mM and 16.7 mM glucose.

Animals↗
PubMed1976

Coordination of auditory and visual space in newborn human infants.

Two experiments are reported which demonstrate that the newborn human infant can make eye movements which are spatially coordinated with the locus of a sound. The results suggest that there may be an innate coordination of auditory and visual-motor space.

Auditory Perception↗