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Biomedical subjects

M C Gregory

Publications and source records attributed to M C Gregory.

At least 55 records · Page 3Linked to original sources
PubMed1986

Failure to visualize acutely injured kidneys with technetium-99m DMSA does not preclude recoverable function.

A 35-yr-old patient developed severe acute tubular necrosis requiring hemodialysis. A [99mTc]dimercaptosuccinic acid scan of the kidneys showed no renal uptake at 4 or 24 hr, but the patient subsequently recovered normal renal function as judged by a normal serum creatinine. Based on this case report and a review of the literature, one cannot assume irreversible loss of function in patients with acute renal failure, based on the absence of radiopharmaceutical uptake by the kidneys.

Acute Kidney Injury↗
PubMed1985

Standardized treatment of severe methanol poisoning with ethanol and hemodialysis.

Seven patients with methanol poisoning were treated with ethanol, hemodialysis and supportive measures. The interval between ingestion and initiation of ethanol therapy varied from 3 to 67 hours and from ingestion to dialysis from 9 to 93 hours. All patients survived, but one had permanent visual impairment. A 10% ethanol solution administered intravenously is a safe and effective antidote for severe methanol poisoning. Ethanol therapy is recommended when plasma methanol concentrations are higher than 20 mg per dl, when ingested doses are greater than 30 ml and when there is evidence of acidosis or visual abnormalities in cases of suspected methanol poisoning.

Adolescent↗
PubMed1984

Hemodialysis does not affect erythrocyte sodium-lithium countertransport.

Sodium-lithium countertransport measurements on erythrocytes are currently of interest because some hypertensive subjects and their relatives have abnormally high values. Woods et al [1] reported that red cells taken from dialysis patients after hemodialysis had significantly lower sodium-lithium countertransport than before dialysis. They suggested that sodium-lithium countertransport is influenced by 'a dialyzable plasma factor'. We conducted experiments to further evaluate their observations relating to the 'dialyzable plasma factor'. However, we have been unable to confirm their findings. Neither an effect of hemodialysis on sodium-lithium countertransport in erythrocytes from maintenance dialysis patients nor any effect of dialysis on normal erythrocytes in vitro was evident. Our results do not support the existence of a dialyzable plasma factor affecting sodium-lithium countertransport.

Adult↗
PubMed1984

The clinical significance of candidal casts.

Examination of the urinary sediment for fungal casts is a new and simple approach for assessing renal involvement in fungal infections. Identification of candidal casts was used to diagnose renal fungal involvement in five immunocompromised patients. In three cases, the examination of the urinary sediment permitted the diagnosis of early and presumably noninvasive renal candidal infections that cleared easily with relatively low doses of antifungal therapy. In two other cases, the recognition of candidal casts confirmed renal involvement in patients with disseminated disease.

Adult↗
PubMed1983

Pregnancy and cystinuria.

46 pregnancies in patients with cystinuria treated with a high fluid intake alone or in combination with D-penicillamine resulted in 41 normal births. New stones formed in 18 pregnancies, with stone passage early in 4 of them. No patient required stone removal during pregnancy. Other pregnancy-related problems included hypertension and urinary-tract infection, which responded to conventional management. Assiduous maintenance of a sustained high fluid intake is even more important than usual during pregnancy and the puerperium. D-penicillamine appears relatively safe for severe cases, although most patients can be managed without it. With careful medical management stone-forming cystinurics can be safely conducted through pregnancy without increased risks to the mother or fetus.

Birth Weight↗
PubMed1983

Toxic shock following staphylococcal peritonitis.

A case of toxic shock syndrome (TSS) in a male continuous ambulatory peritoneal dialysis (CAPD) patient is described. The prodromal phase started with staphylococcal peritonitis and deteriorated to the malignant phase of TSS approximately 48 hours from the time he presented to the local emergency room. Desquamation first affected the extremities and likely involved his gastrointestinal tract. His course of peritonitis involved unusual pain, with progression into toxic shock in spite of appropriate antibiotic coverage.

Adult↗
PubMed1979

Absorption of iron polymaltose and ferrous sulphate in rats and humans. A comparative study.

Free iron in the circulation in contrast to iron complexed with protein or carbohyrdate, is intensely toxic. The annual morbidity and mortality from accidental overdose with iron salts is significant and has directed attention to the evaluation of safer forms of therapy. Comparative studies between oral ferrous sulphate and iron polymaltose in rats established an LD100 of 350 mg/kg for the salt, whereas neither morbidity nor mortality could be produced in doses exceeding 1 000 mg/kg for the complex. Bio-availability of iron from salt and complex for haemoglobin synthesis was then compared both in rats and in man with a twin-isotope technique. In experimental animals and in the human studies, venesected individuals were used to reproduce the iron deficiency state where treatment would be indicated. It was concluded that bioavailability is comparable for therapeutic doses of ferrous sulphate and iron polymaltose in iron-deficient subjects. The marginally lower absorption of complex was offset by a greater degree of gastrointestinal tract tolerance; the wide margin of safety may be of importance in reducing the danger of accidental iron overdose.

Anemia, Hypochromic↗
PubMed1977

Clofibrate-induced complications in renal disease: a case report.

A young male nephrotic patient, who was given small doses of clofibrate for hyperlipaemia, developed muscle pain, stiffness and very high serum levels of muscle enzymes. The myopathy remitted completely after administration of clofibrate was stopped. He also displayed a transient mononeuropathy and rapid deterioration of previously stable renal function, so that he required maintenance dialysis. Clofibrate has particular dangers in patients with uraemia or hypoproteinaemia, and we recommend that it be used with great caution in patients with renal disease.

Adult↗
PubMed1976

Changes in cardiac and hepatic glucocorticoid receptors after adrenalectomy.

1. The total number of specific dexamethasone-binding sites in rat heart and liver cytosol was measured at intervals after adrenalectomy. 2. Between 12 and 48 h after adrenalectomy there was a significant increase in the number of binding sites in both heart and liver cytosol. Affinity was unchanged. 3. Of the [3H]corticosterone bound to liver cytosol proteins after an intravenous injection 98% disappeared within 2 h in vivo. Dissociation of endogenous corticosterone-receptor complexes in liver cytol will thus be substantially complete some hours before the number of receptors increases. 4. It was concluded that there is a true increase in the number of glucocorticoid receptors occurring principally between 12 and 48 h after suppression of endogenous steroids.

Adrenalectomy↗