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Biomedical subjects

M Bruze

Publications and source records attributed to M Bruze.

At least 127 records · Page 7Linked to original sources
PubMed1994

Systemically induced contact dermatitis from dental rosin.

Rosin is a ubiquitous contact sensitizer which may be present in dental materials such as periodontal dressings, impression materials, cements, and cavity varnishes When a hypersensitive person is exposed to a sensitizer, allergic contact dermatitis/stomatitis may develop, most commonly after direct skin/mucosa contact with the sensitizer. However, widespread dermatitis may develop after systemic administration of the sensitizer, and this paper reports the case of a rosin-hypersensitive man who developed widespread eczematous dermatitis after dental treatment with a rosin-containing product.

Balsams↗
PubMed1994

Quinine and quinidine photoproducts can be identical.

Quinine and its d-isomer quinidine can both cause contact allergy as well as photoallergy. Contact allergic cross-reactions between quinine and quinidine are uncommon. In allergic photosensitization the two isomers cross-react, suggesting the possibility that quinine and quinidine after UV exposure are converted to one or more common sensitizing photoproducts. Solutions of quinine and quinidine at 0.1% in ethanol 99.5% were exposed to UVA for 14 h (total dose 201.6 J/cm2). Using thin-layer chromatography, we identified 8 and 6 photoproducts from irradiated quinine and quinidine, respectively. Five of these photoproducts were seen in both chromatograms. An identical pattern with four photoproducts was found for both irradiated solutions when these were subjected to analysis in a high-performance liquid chromatography system. This study indicates that photoproducts from irradiated quinine and quinidine can be identical. This would explain the differences in the cross-reactivity pattern between contact and photocontact sensitization clinically.

Chromatography, High Pressure Liquid↗
PubMed1994

Dermatitis with an unusual explanation in a welder.

Occupational diseases among welders include asthma, acute keratoconjunctivitis, and various skin disorders. A localized cutaneous erythema from UVC radiation is common and does not generally constitute any problem, as its cause is obvious to the welder, the symptoms are slight, and it is transient. In this report a welder with UVC-induced erythema on the cheeks is described. Initially, neither the worker, the physician at the factory, nor ourselves suspected a UVC erythema. Extensive investigations, including factor visits with measurements of UVA, UVB, and UVC irradiance during welding, revealed the cause of the dermatitis to be UVC, most likely reflected from a textile hood used to prevent exposure to dirt.

Adult↗
PubMed1994

The histological and immunohistochemical pattern of positive patch test reactions to gold sodium thiosulfate.

Gold sodium thiosulfate, inserted in the patch test standard series, gives a surprisingly high yield of positive reactions, about 10% of tested eczema patients, but with a low degree of clinical relevance. A histopathological study on patch test reactions was carried out in patients selected because of a combined contact allergy to gold sodium thiosulfate and nickel. Biopsies were taken from macroscopically similar reactions in dilution series of each allergen. The histological picture was clearly eczematous, without irritative features. In a blind comparison, test reactions induced by the two allergens could not be differentiated from each other. Long-lasting patch test reactions to gold sodium thiosulfate were characterized by an intense lymphocytic dermal infiltrate without epidermal involvement. Immunohistochemically, CD4+ and CD8+ T lymphocytes could be detected already 4-8 h post-challenge, and "naive" as well as "memory"-type T cells were demonstrated. Apparently, our findings reflect a true contact allergy to gold sodium thiosulfate.

Adult↗
PubMed1993

Contact allergy to Duraphat.

Skin-sensitizing rosin is present in Duraphat, a fluoride varnish used all over the world. Two cases of hypersensitivity to Duraphat are presented: a dental nurse with dermatitis of the hand and a patient with allergic contact stomatitis.

Dermatitis, Allergic Contact↗
PubMed1990

Allergic contact dermatitis from diphenylthiourea in Vulkan heat retainers.

11 cases of contact dermatitis from Vulkan heat retainers are reported. The skin eruptions started on days 1-11 after the 1st day of exposure. The clinical picture varied from eczema through urticaria to purpura. In some cases, the symptoms were severe. Patch testing was performed in 10 individuals and all reacted positively to the heat retainer and/or the rubber glue used in the heat retainer. A series of rubber chemicals was patch tested in 7 patients and all showed positive reactions to diphenylthiourea (DPTU), and all but one to ethylene thiourea (ETU). TLC examination revealed a spot with the same RF-value as DPTU in extracts of the adhesive, but no spot corresponding to ETU. There were no indications of impurities in the test preparations of DPTU and ETU. By HPLC, the content of DPTU in the adhesive was determined as 0.6% w/w.

Adhesives↗
PubMed1990

Chromate sensitization and elicitation from cement with iron sulfate.

For some years, iron sulfate has been added to cement manufactured in the Scandinavian countries to prevent sensitization to and elicitation from chromate in cement. Allergic contact dermatitis from chromate is reported here in 3 workers with hand dermatitis and exposure to cement containing iron sulfate. Although iron sulfate had been added to the cement, high chromate concentrations were found in many samples of cement to which these workers were exposed.

Adolescent↗
PubMed1990

PABA, benzocaine, and other PABA esters in sunscreens and after-sun products.

Contact/photocontact allergy to PABA and benzocaine are not uncommon. PABA and PABA esters are used in sunscreens and benzocaine may contaminate such sunscreens or may be an intentional constituent in after-sun products. Labelling of ingredients in sunscreens and after-sun products is not required by law in Sweden. The presence of PABA, PABA esters used as sunscreen agents, and benzocaine was therefore investigated by HPLC in 97 sunscreens and 15 after-sun products. PABA was detected in 2 sunscreens while almost 50% of the sunscreens contained 2-ethylhexyl p-dimethyl-aminobenzoate. Benzocaine was not found in any after-sun product but was present in 1 sunscreen containing 4-bis(hydroxypropyl)aminobenzoate. Glyceryl p-aminobenzoate and amyl p-dimethyl-aminobenzoate were labeled on 1 and 3 sunscreens, respectively, but glyceryl p-aminobenzoate was not found in any of them and only traces of amyl p-dimethylaminobenzoate were found in 1 sunscreen.

4-Aminobenzoic Acid↗
PubMed1990

Patch testing with cement containing iron sulfate.

Addition of iron sulfate to cement means transformation of water-soluble hexavalent chromium into nonwater-soluble trivalent chromium. This has been the basis for preventive measures concerning sensitization to hexavalent chromium (chromate) in cement. For some years, iron sulfate has been added to cement manufactured in the Scandinavian countries. In the present in vivo study, cements with and without iron sulfate were compared concerning their capacity to elicit allergic patch-test reactions in eight chromate-hypersensitive individuals. No patch-test reactions were obtained from a water extract of cement with iron sulfate when appropriately buffered.

Chromium↗