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Biomedical subjects

M Brice

Publications and source records attributed to M Brice.

51 records · Page 3Linked to original sources
PubMed1977

[X-ray diffraction of the collagen contained in blood vessels].

An X-ray diffraction study has been undertaken on Human and Rabbit blood-vessels. Vessels are stretched 500% and the diagrams present a great analogy with those obtained from collagen. Thus, it appears, that it is possible to determine by X-Rays some pathological anomalies of the collagen in vessels.

Animals↗
PubMed1977

Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells.

The in vitro regulation of fetal hemoglobin (HbF was investigated in clones of cultured adult human erythroid cells by in situ immunofluorescent identification of the hemoglobins synthesized. Formation of Hb F-containing clones was enhanced by erythropoietin and by culture conditions favoring the proliferation of less-differentiated stem cells of the burst-forming-unit type. Burst-forming units differed in their capacity to direct Hb F synthesis in their terminally differentiated progeny. A class of early precursors that can produce descendent stem cells with or without commitment to Hb F production was identified. The findings suggest that the capability for expression of Hb F in terminally differentiated cells of the adult is determined at the level of less-differentiated erythroid stem cells with characteristics of burst-forming units. It is proposed that the regulation of Hb F synthesis in vivo is also linked to the process of differentiation of the erythroid stem cells and that the patterns of Hb F synthesis during ontogeny reflect the attainment of progressively higher levels of differentiation of erythroid stem cells as development proceeds.

Adult↗
PubMed1976

Stimulation of fetal hemoglobin synthesis in bone marrow cultures from adult individuals.

The regulation of fetal hemoglobin in adult erythroid cells was investigated with bone marrow cultures. Fetal hemoglobin (Hb F) was identified in individual erythroid colonies with fluorescent antibodies against Hb F and synthesis of gamma chains was determined with analyses of radioactive globins. The appearance of fetal hemoglobin in erythroid colonies was clonal. All the cells of the Hb F synthesizing colonies contained fetal hemoglobin. The frequency of erythroid colonies showing Hb F was higher than expected compared to the frequency of Hb F containing cells in the blood. Production of Hb F in culture, as shown by analysis of the radioactive globins, was 5 to 14 times higher than baseline Hb F synthesis. These results suggest that the ability for gamma chain synthesis in erythroid cells is determined at or above the level of the precursor cell from which the erythroid colonies, in vitro, derive (probably an erythropoietin responsive stem cell), and that stimulation of fetal hemoglobin synthesis in adult erythroid cells is possible.

Aging↗
PubMedDate not supplied

[Evolutive stages of the iliac compression syndrome (Cockett's syndrome) (author's transl)].

The term of Cockett's syndrome stands for a lower limb dysfunction with venous stasis originating from the left common iliac compression by the right common iliac artery at the pelvis inlet level. For the authors, there are three evolutive stages. First stage: a simple compression without any anatomic venous parietal lesion. Second stage: to the previous, are added left common iliac vein lesions consisting of an inner vascular band formation. This must be surgically treated to remove the obstacle. Third stage: the final evolution: the ilio-femorale thrombosis. Therefore, the diagnosis must be done as early as possible. It lies on the left lower limb phlebography.

Adult↗
PubMedDate not supplied

[Vascular injuries associated with osteoarticular lesions of the lower extremities].

The authors report 38 observations of vascular traumatisms associated to osteo-articular lesions of lower members cured by restorative treatment. The authors define a diagnostic and therapeutic line of conduct. They insisted upon the necessity of early diagnosis of vascular lesion, based on ultrasonic exploration of vessels as soon as the patient was admitted to hospital. Restoration must be considered from a global point of view in taking into account the state of integuments , the type of selected osseous restoration, the vascular approach and the possible necessity of aponeurotomy . The importance of vascular lesion and the slowness of circulation restoration induced the results of the treatment, the major risks of which were infection and metabolic lesion of the kidney. In 18% of the cases amputation was necessary.

Adult↗