Search PubMed⌕ Search

Biomedical subjects

M Brandt

Publications and source records attributed to M Brandt.

At least 145 records · Page 8Linked to original sources
PubMed1983

[Porphyria in pregnancy].

The report concerns two cases of pregnant women, one suffering from a acute photosensitive hepatic porphyria, the other suffering from a congenital erythropoietic porphyria. The course of pregnancies with porphyria, described in the literature, the interactions between pregnancy and porphyria, the influence of hormones and drugs, the indications for interruption of pregnancy, and problems of anesthesia are discussed.

Adult↗
PubMed1982

[Action of oral contraceptives on circulating immune complexes (author's transl)].

Three methods for immune complex detection were used on 85 women who took oral contraceptives and on 21 who took none to test their sera for circulating immune complexes. The methods were ammonium sulphate precipitation as proposed by Beaumont et al., polyethylene glycol precipitation, and the 125J-Clq fixation test. - Significant rise in precipitable proteins, in excess to anything recordable from women with no oral contraceptives, was established from the oral-contraceptive group only by means of 25-per-cent ammonium sulphate precipitation. No significant difference between the two groups could be measured by the two other techniques. - Ammonium sulphate precipitation is not specific of immune complexes, and no difference between the two groups was recordable by means of the 125J-Clq fixation test, a technique more specific of immune complexes. The conclusion, therefore, was drawn that the proteins which had caused rise in ammonium sulphate precipitation had been proteins of unspecific precipitability rather than immune complexes. - Findings so far obtained are likely to suggest that administration of oral contraceptives will hardly induce formation of circulating immune complexes.

Adult↗
PubMed1982

[Pregnancy, labor and the puerperium in women with genital malformations].

An account is given of pregnancy, puerperium, and labour of 49 women of whom the majority had malformations of the uterus varying in extent. Most of these uterine malformations were detected from occurrence of intrapartal complications. Therefore, presence of malformation not yet known should be an assumption, whenever disorders occur right after birth.

Abortion, Spontaneous↗
PubMed1981

[Hormonal contraceptives of differentiated composition -- effects on thrombocyte function (author's transl)].

The number, proliferation, and aggregation of thrombocytes, platelet adhesiveness, and thromboblastographic values were investigated in the context of 52 women, who were on a compound hormonal contraceptive with threefold-differentiated gestagen, and of ten women with a compound hormonal contraceptive of two-fold gestagen differentiation. Tests were conducted over six months. Significant deviations from normal values were recordable. No definite conclusions, however, can be drawn from such individual observations. Disorders in thrombocyte function and change in thromboblastographic values, when considered with all their implications, are likely to suggest the presence of effects from hormonal contraceptives. Yet, both type and concentrations of oestrogens and gestagens are of minor importance to such change. Nevertheless, somewhat higher risk of thrombo-embolism should be assumed, if other conductive factors are present, at the same time.

Blood Platelets↗
PubMed1981

[Post-pill amenorrhea following hormonal contraceptive therapy in adolescence (author's transl)].

Disorders of the ovarian function after going off hormonal contraceptives are a serious complication when appearing as postpill amenorrhea in young nullipara. We could diagnose a postpill amenorrhea in 31 cases out of 52 patients suffering from functional ovarian disorders after stopping the application of hormonal contraceptives. 19 woman younger than 28 years and wanting to get pregnant had begun as adolescents to take contraceptive drugs. Concerning the etiology of post-pill amenorrhea the type of contraceptive is of importance as well as predisposing factors such as late menarche, unstable menstruation and other cycle anomalies. Our patients majority had taken gestagen-accentuated combination drugs. During adolescent age there should be prescribed only sequential drugs if necessary.

Adolescent↗
PubMed1980

[Surgical therapy of trigeminal neuralgia. Selective thermocoagulation of Gasser's ganglion].

These first ultrastructural studies of the effect caused by thermocoagulation of a ganglion (ganglion inferius nervi vagi) akin to the Gasserian ganglion have shown that selective pain fiber elimination can only be expected from thermocoagulation at temperatures not higher than 50 degrees C/60 s or 60 degrees C/60 s. Even if the results of these animal experiments can only be applicable to clinical practice in the sense of an analogical conclusion, we are nevertheless of the opinion that it can be recommended to begin the thermocoagulation in trigeminus neuralgia at low temperatures (50 degrees C/60 s or 60 degrees C/60 s) and only if found necessary, after checking the sensitivity to pain, to increase it in steps of 5--10 degrees C.

Animals↗
PubMed1980

Spontaneous intramedullary haematoma as a complication of anticoagulant therapy.

We report an intramedullary haematoma that occurred as a complication of anticoagulant therapy. Contrary to the well-known epidural spinal haematomas an intramedullary haemorrhage, to our knowledge, has not been reported. The necessity for myelography and operation immediately after the appearance of typical clinical signs such as local vertebral pain and early paraparesis is stressed. The possibilities for reversing the effect of anticoagulants are outlined, and the problem of continuing thrombo-embolic prophylaxis postoperatively are discussed.

Anticoagulants↗
PubMed1980

[Hypophysectomy in metastasing carcinoma of the breast (author's transl)].

As result of a poll, the opinion of 50 Neurosurgical Departments in the Federal Republic of Germany relating to the importance of hypophysectomy in the therapy of metastatic carcinoma of the breast was obtained. Four of 32 replies prefer a regular hypophysectomy and 11 departments do the hypophysectomy only in exceptional cases. In 17 clinics this operation is not used. It should be emphasized, that a quarter of those neurosurgeons, who took part in our inquiry, had already given up hypophysectomy some years ago. About 50% of the surgeons talk about positive effects on metastatic carcinomas. The hormonal dependence of disseminated cancers is the only condition, which has to be presumed. Implantation of radioisotopes and trans-sphenoidal hypophysectomy are mentioned as the main operative techniques. The indications for hypophysectomy for metastatic carcinoma of the breast are discussed in the light of the recent literature. If one considers the possibilities of radiotherapy and chemotherapy, hypophysectomy can still be of considerable value as a palliative measure in hormone-dependent tumours with bone metastases, provided that the cases are carefully selected.

Bone Neoplasms↗
PubMed1980

[Pregnancy, delivery, and puerperium of patients with constitutional thrombopathy (author's transl)].

Von Willebrand's disease was found to play a particular role in obstetrics for its physiological peculiarities of coagulation which cause haemorrhage disorders after childbirth and during the puerperal period rather than during pregnancy and in concomitance with labour. A comprehensive account of the problem is given, with reference being made to the author's cases.

Blood Coagulation Tests↗