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Biomedical subjects

M Bonnet

Publications and source records attributed to M Bonnet.

At least 145 records · Page 8Linked to original sources
PubMed1986

[Retinal detachment caused by small tears in the equatorial region of the retina].

46 Phakic rhegmatogenous retinal detachments due solely to round atrophic holes in the equatorial region were observed in 42 patients. The clinical characteristics and the prognosis of the retinal detachments differ from those of retinal detachments associated with horse-show retinal tears. The 46 phakic retinal detachments due solely to round atrophic holes in the equatorial region account for 5.8% of all rhegmatogenous retinal detachments operated during the same period of time, 81% of the patients were under 40 years of age, 93.5% of the eyes were myopic. The round atrophic holes were located within foci of equatorial lattice degeneration in 97.8% of the eyes. The number of holes per eye varied from 1 to 16 with a mean number of 4.54. The location of the holes showed a significant prevalence for the lower temporal quadrant (83.3% of the eyes) and then the upper temporal quadrant (47.8% of the eyes). The retinal detachments had a slow progression and demarcation lines were present in 56.5% of the eyes. In spite of the long standing duration none of the detachments were associated with clinical evidence of proliferative vitreo retinopathy. Surgical prognosis was excellent. Retinal reattachment was achieved in all cases. Post operative visual acuity of 20/40 or better was achieved in 60% of the eyes. It is assumed that the absence of proliferative vitreo retinopathy in those retinal detachments is related to the absence of significant vitreous degeneration and posterior vitreous detachment.

Adolescent↗
PubMed1985

An ultrasonographic study of choroidal indentation height after scleral buckling with lyophylized human tissues.

The height of the choroidal indentation produced by 26 lamellar scleral pockets filled with lyophylized human fascia lata and by 9 exoplants made up of lyophylized human dura mater was measured with A-scan and B-scan ultrasonography. The mean height of the choroidal indentation produced by lamellar scleral pockets was 4.3 mm 5-20 days postoperatively, 3.2 mm 3 months postoperatively, and 2.5 mm 6-9 months postoperatively. The mean height of the choroidal indentation produced by exoplants made up of dura mater was 4.6 mm 5-20 days postoperatively, 3.5 mm 3 months postoperatively, and 2.9 mm 6 months postoperatively.

Choroid↗
PubMed1985

Influence of magnesium deficiency on liver collagen after carbon tetrachloride or ethanol administration to rats.

The effects of magnesium deficiency on liver collagen after the administration of a hepatotoxic substance were investigated. Rats, fed a control or magnesium-deficient diet (0.040 g/kg), received six CCl4 or mineral oil injections administered at 2-d intervals starting from the first day of diet treatment. They were killed 3 or 12 d after the last injection. Between postinjection d 3 and 12, no change of magnesium concentration in liver was observed in the deficient rats. Three days after the end of treatment liver calcium in the magnesium-deficient CCl4-treated rats was higher than in any other group. Liver collagen of untreated control rats and untreated magnesium-deficient rats was not significantly different. In control and magnesium-deficient animals receiving CCl4 treatment, the liver collagen levels were significantly higher than in untreated rats. The magnesium-deficient rats receiving CCl4 have higher liver collagen than the controls receiving CCl4. In a second experiment the effect of suboptimum intake of magnesium (0.120 g/kg) combined with the ingestion of ethanol was studied in rats given a solution of ethanol in water for 55 d as their only source of fluid. Mortality occurred in the magnesium-deficient rats receiving ethanol, and body weights of these rats were lower than those of animals in the other three groups. The collagen concentration in liver was higher in magnesium-deficient rats consuming ethanol than in any other group. The synergistic action between magnesium deficiency and ethanol therefore appears to be analogous to that observed with CCl4.

Animals↗
PubMed1985

[Surgical occlusion of 2 vortex veins in the treatment of decompensated senile macular degeneration. A longer-term evaluation].

Microsurgical occlusion of two vortex veins was carried out on seventeen eyes of 16 patients affected with senile pigment epithelial detachment. Ten eyes had avascular pigment epithelium detachment and 7 eyes had pigment epithelium detachment associated with choroidal new vessels. Regression or stabilisation of the fundus lesions occurred in one of the eyes affected with vascular pigment epithelium detachment. On the other hand 3 months postoperatively, the pigment epithelium detachment had flattened with significant improvement of the visual acuity, in 4 of the 10 eyes affected with avascular pigment epithelium detachment. However the results were not as satisfactory after a longer follow-up. The improved visual acuities noted at 3 months, gradually deteriorated after 6-12 months in most patients and 4 eyes showed subsequent clinical evidence of active disease. The results of the present study lead to conclude that the surgical occlusion of 2 vortex veins does not provide a satisfactory answer to the treatment of senile pigment epithelial detachment.

Aged↗
PubMed1985

[Long-lasting expansive gases in the treatment of rhegmatogenous retinal detachment associated with vitreoretinal proliferation].

Thirty two eyes of 32 patients affected with rhegmatogenous retinal detachment (R.D.) associated with proliferative vitreoretinopathy (P.V.R.) were operated on with combined external and endovitreal microsurgery. Internal tamponade was carried out with SF6 in 16 eyes and C3F8 in 16 eyes. All patients were followed for at least six months after the last surgical procedure. Permanent retinal reattachment was achieved in 56% of the eyes operated on with SF6 and 60% of the eyes operated on with C3F8. Surgical success was achieved with only one operation in those eyes operated on with C3F8. In contrast, 88% of the eyes successfully operated on with SF6, had more than one operation. The overall surgical results, whatever the gas used for internal tamponade, are as follows: surgical success was achieved in 83% of P.V.R. cases grade C1 and C2 (5 cases out of 6), 73% of P.V.R. cases grade C3 and D1 (11 cases out 15), and 20% of P.V.R. cases grade D2 and D3 (2 cases out of 10).

Adolescent↗
PubMed1985

[N-acetyl-aspartylglutamic acid eye drops in allergic-type conjuctivitis. Double-blind comparative clinical study].

Fifty patients with allergic conjunctivitis were included in a double-blind randomized clinical trial designed to compare the efficiency and tolerance of two antiallergic eye-drops: one containing NAAGA (22 patients), the other one containing disodium Cromoglycate (28 patients). Both treatments were used at a dosage of 1 drop 4 times per day. Ocular symptoms, conjunctivo-corneal signs and the subjective ocular condition assessed by the patients themselves with visual analogue scales, were all significantly improved by both eye-drops during the first month of treatment. Statistical analysis showed that patient ocular condition improved more rapidly with NAAGA eye-drops. In 25 patients (12 in the NAAGA group and 13 in the Cromoglycate group), the study was continued for an additional month according to a cross-over protocol. During the 2nd month of treatment, additional improvement of ocular symptoms and signs were observed with both eye-drops but more markedly in those patients who received NAAGA after Cromoglycate. Ocular tolerance was good for both eye-drops.

Adolescent↗
PubMed1985

[Diathermy and cryotherapy of the pars plana in the treatment of pars planitis. Long-term evaluation].

Seventeen eyes of 14 patients affected with severe pars planitis underwent surgical treatment with either cryotherapy - 3 eyes - or diathermy - 14 eyes. The indications for surgery were selected as follows: ten eyes of 9 patients showed recurrence(s) or increase of ocular inflammation following tapering of systemic corticoids; 5 patients had contra-indications to systemic corticoids. Ten eyes had cystoid macular edema. The follow-up after surgery varies from 2,5 years to 10 years with an average of 5 years. Complete and permanent recovery from ocular inflammation was achieved in 7 eyes (41,2%). Permanent although incomplete improvement was achieved in 4 eyes (23,5%). Recurrences of ocular inflammation after incomplete improvement occurred in 4 eyes (23,5%). Complications - cystoid macular degeneration and severe ocular hypotension - occurred in 2 eyes (11,8%). Cystoid macular edema cleared in 9 out of 10 eyes. The final visual acuity was the same or better as compared to the initial visual acuity in 10 eyes, and worse in 7 eyes. It is concluded that the long term evaluation of cryotherapy and diathermy in the treatment of pars planitis confirms the results achieved in other series with a shorter follow-up. The treatment is beneficial in selected cases of severe pars planitis. However complete and permanent recovery from ocular inflammation should be expected in less than 50% of the cases.

Adolescent↗
PubMed1984

Preparatory process for anticipatory postural adjustments: modulation of leg muscles reflex pathways during preparation for arm movements in standing man.

We have investigated, in 6 standing subjects, the time course of amplitude changes in the short latency (40-60 ms) and long latency (60-80 ms) reflex response components of gastrocnemius medialis (GM) and soleus (S) muscles during the preparatory period (time between a warning signal and a response signal) as a function of the precued direction (pull or push) of arm movement. Subjects maintained their standing posture by visual feedback during the 1.5 s preparatory period of a reaction time task. A warning signal gave advance information concerning the voluntary response to be performed which consisted of either a pull or push movement of the right arm. The excitability of the reflex pathways was evaluated by triggering a rapid rotation of the right ankle joint (dorsiflexion) applied randomly at 100, 300 or 500 ms before the response signal for arm movement. Statistical analysis of EMG amplitude (ANOVA) showed that preparatory effects were different for the two synergistic muscles with both short (spinal) and longer latency components of GM showing generalized facilitation and of S showing generalized inhibition. In addition, the longer latency, presumably supraspinal, component of the two muscles was differentially modulated according to directional advance information, showing relative facilitation for pull as compared to push trials. These reflex response modulations were emphasized in faster reaction time (RT) performers at the end of the preparatory period. It is concluded that postural preparatory processes are reflected at the spinal level in global effects and at the supraspinal level in directionally specific effects.

Adolescent↗