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Biomedical subjects

M Bisson

Publications and source records attributed to M Bisson.

At least 73 records · Page 4Linked to original sources
PubMed1983

[Pharmacology and mechanism of action of D-penicillamine in rheumatoid polyarthritis].

The authors discuss current pharmacological knowledge of D-Penicillamine (DP) in man and its possible mechanism in the treatment of rheumatoid polyarthritis. Dosage by liquid phase chromatography enables study of intestinal absorption, reduced by meals, the distribution made according to a 2 compartment model, urinary and faecal excretion. Metabolism occurs mainly by oxidation of free D-Penicillamine. 20 percent of the plasmatic DP, not bound to proteins, appears in the form of disulphides and free DP. The only known metabolite is S-methyl DP, produced in small amounts. The DP mechanism remains hypothetical. The authors discuss its effects on the metabolism of copper and zinc, dismutatic super-oxide activity, the radical thiol level, collagen metabolism, cartilaginous destruction, prostaglandin synthesis, polynuclear chemotaxis and the immuno-system.

Arthritis, Rheumatoid↗
PubMed1983

[Retrospective study of the effects of D-penicillamine and pyrithioxin in the treatment of rheumatoid arthritis].

The authors made a comparative study of the effectiveness and tolerance of D-penicillamine (DP) and pyrithioxine (Pyr) and investigated possible prognostic factors for the tolerance and effectiveness of these two treatments. This retrospective study concerned 150 patients with rheumatoid arthritis (RA). 86 patients were treated with DP and 64 were treated with Pyr. The percentage effectiveness, evaluated in terms of morning stiffness and the articular index as well as the need for steroidal and non-steroidal anti-inflammatory agents, attained 67.4 p. cent with DP and 51.6 p. cent with Pyr. Suspension of treatment because of ineffectiveness, was more frequent with Pyr. The changes in the following laboratory parameters were also compared: ESR, rheumatoid serology, ANF, C3 and C4 complement levels, IgG, IgA and IgM levels. The treatment was stopped definitively because of intolerance in 37.2 p. cent of cases with DP and in 29.7 p. cent of cases with Pyr. Serious renal and haematological complications are essentially, but not exclusively, due to DP.

Arthritis, Rheumatoid↗
PubMed1979

[Cryoglobulins and circulating immune complexes in rheumatoid arthritis. Clinical and biological correlations].

We studied circulating immune complexes using a test involving the precipitation of these complexes with polyethylene glycol 6000 at 2.5 percent, and characterization of the Clq bound in vivo to immunoglobulins in the serum of 126 healthy subjects, 95 hospitalized controls and 181 patients suffering from rheumatoid arthritis (RP). Likewise, the RP benefited from a study of cryoglobulins (CG). The PEG-Clq proved positive (PEG +) in 7 per cent of the healthy controls, 25 per cent in the seronegative RP. ThePEG & RP have a level of proteins, gammaglobulins, IgM and IgG that is higher than in patients in whom the test is negative. On the other hand, they have a lower level of C4. One CG was detected in 43 patients who were all PEG +. The level of CG is proportionate to the intensity of the articular inflammation, the sedimentation rate, the level of seric iron and that of hemoglobin. The composition of the precipitins obtained by activity of the PEG is very close to that of the CG.

Adolescent↗
PubMed1976

[IgM myeloma].

The authors report the case of a 62 year old woman in whom bony pain led to the discovery of lacunar osteolytic appearances, in particular in the skull, abnormal medullary plasmacytosis and serum monoclonal immunoglobulin with Bence-Jones proteinuria. The case was unusual as the immunoglobulin observed was an IgM. This finding led the authors to a critical revision of the distinctive characteristics of multiple myeloma and Waldenström's macro-globulinemia, emphasizing the distinguishing value of the cytological criterion. The authors recall the various neoplastic proliferations of the B lymphocytes at the various stages of their maturation and emphasize the predominance of monoclonal IgM during proliferations affecting the early stages of maturation of the B lymphocytes and the rareness of these IgM during plasma cell neoplasms.

B-Lymphocytes↗
PubMed1976

[Paget's disease with osseous demineralization (author's transl)].

Radiological diagnosis of Paget's disease which is based on hypertrophy of the osseous cortex, osteocondensation and a fibrillary appearance of the cancellous bone, can be rendered difficult when there is superadded demineralization. This is usual in the initial phase of the condition and take on the form of circumscribed osteoporosis. Such an appearance can however be misleading owing to its wide extent or to the number of localizations, as was the case in two of our cases; the diagnosis of Paget's disease must then be established from histological criteria. Besides this demineralization which is directly related to the morbid process in Paget's disease, calcium deficiency is known to modify the clinical and radiological symptomatology of Paget's disease. Our first two cases illustrate this fact and the remarkable effectiveness of "remineralization" therapy in such cases.

Aged↗
PubMed1975

Plasma erythropoietin assay in patients with chronic renal failure.

Using the post-hypoxic mouse method of assay, values for erythropoietin in the plasma of patients with chronic renal failure were equal to, or greater than, normal values. Results suggest that the source of erythropoietin may be primarily extrarenal. Normal renal tissue, provided in the assay by the intact mouse, is required for activation of the hormone. There still remains to be explained the enhanced erythropoietic response to haemorrhage or hypoxia that can occur in anephric man.

Erythropoietin↗
PubMed1975

[Acquired vertebral block with bone demineralization during Paget's disease].

The authors report an observation on a man 68 years of age suffering from Paget's disease in the pelvi-rachidian region. In four years the lumbar lesions evolved to form an L2-L4 vertebral block. The intensity of the bone radiotransparency of the vertebral block indicated some similarity to the localized forms of osteolysis well known in the skull and the long bones.

Aged↗