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Biomedical subjects

M Bisson

Publications and source records attributed to M Bisson.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Prognostic and therapeutic significance of bone marrow biopsy in multiple myeloma. Analysis of 31 stage II A and III A patients].

The prognostic value of bone marrow biopsy was established in 31 patients suffering from stage IIA and IIIA myeloma (Durie and Salmon classification). Data obtained from quantitative marrow cytology permit to differentiate 3 sub-groups of cells: plasmocytes, plasmoblasts, plasmocytes/plasmoblasts of which the incidence on the prognosis and the response to treatment was studied. There is a correlation between the response to MP and the nature of various cells populations and, on the other hand, the type of infiltration. A sub-group of patients, resisting to MP, was identified: diffuse plasmoblastic myelomas of poor prognosis. Induction poly-chemotherapy seems far superior over the MP combination, which was always a controverted issue.

Aged↗
PubMed1987

[Heterogenicity of the response to chemotherapy in plasmablastic myeloma].

Several recent studies have identified in multiple myeloma a plasmablastic subgroup characterized by its very sombre prognostic. We report the results of treatment in 10 high risk patients with plasmablastic myeloma stage IIIA in the Durie and Salmon classification, stage III in the Bartl classification (tumoral mass greater than 50%). The median survival of the 10 patients was 8 months. These patients, who were resistant to melphalan-prednisone (M-P) or to VMCP in conventional doses, fell into 2 categories: those who responded to chemotherapy with adriamycin, and those who resisted all types of chemotherapy from the start. The finding of such heterogeneous responses to chemotherapy in the plasmablastic subgroup of multiple myeloma and the usefulness of CALLA+ antigen determination make it necessary to study cell differentiation antigens, which would in the long term alter the therapeutic approach in these patients.

Adult↗
PubMed1986

[Contribution of synovial biopsy in unclassified arthropathies].

The authors report a retrospective study of the diagnostic usefulness of synovial biopsy (SB) in 80 cases of unspecified forms of joint disease. SB was able to indicate the diagnosis in 23 (28.7%) of these patients. These 23 cases included 4 of the 15 cases (26.6%) of acute monoarticular arthritis, 5 (31.2%) of the 16 cases of acute oligopolyarthritis. In 6 cases (7.5%) SB was also responsible for the elimination of an initial diagnosis of septic arthritis. Overall, therefore, SB contributed to establishing a diagnosis and guiding therapy in 20 (36.2%) patients. Despite these rather low percentages, SB appears to be an essential examination, particularly in monoarticular arthritis, for the confirmation or exclusion of the diagnosis of conditions which present specific histologic signs and which require appropriate treatment.

Adolescent↗
PubMed1986

[Therapeutic application of sequential bone marrow biopsy in myeloma: analysis of 13 medullary biopsies].

The therapeutic applications of sequential bone marrow biopsy were investigated in 6 patients with myeloma. Our results showed that the response to chemotherapy is modified by data from quantitative bone marrow cytology which separate subgroups of patients (plasmocytes or plasmoblasts) with different prognosis. The selective disappearance of certain bone marrow components (plasmoblasts and/or diffuse infiltration) after chemotherapy results in tumoral growth retardation which is reflected in a higher objective response rate. These preliminary results emphasize the need for pretreatment bone marrow biopsy in order to select the most appropriate drugs. A prospective study involving a large number of patients is in progress; its purpose is to find out whether adding to the already known clinical classifications a classification based on the type of bone marrow infiltration and on the degree of cell differentiation is therapeutically useful.

Adult↗
PubMed1984

[Involvement of the cervical spine in chronic juvenile arthritis. 29 cases followed for more than 5 years].

Analysis of cervical spine involvement is based on data from 29 cases of juvenile chronic arthritis (JCA), (8 systemic and 21 polyarticular forms). Follow-up is a least 5 years and exceeds 10 years in 17 cases. Among these 29 patients, 14 experienced cervical pain. One patient had Arnold neuralgia. No other neurologic complications were recorded. 14 of the 29 patients exhibited one or more roentgenological changes (3 of the 8 systemic patients and 11 of the 21 polyarticular patients). Of these, 4 never had any corresponding clinical symptoms. A chronologic correlation between onset of clinical and radiological signs was clearly established in only three cases. Among roentgenologic features, loss of physiologic lordosis was recorded in four patients. This finding was always associated with other radiologic changes. Seven patients had involvement of the posterior spine: blurred articular outlines and erosion of posterior epiphyses in one patient, fusion of neural arch joints involving C2-C3 in two patients and C2-C3 and C3-C4 in two others, and extensive fusion from C2 to C7 in two cases. Changes in the anterior spine were always accompanied with posterior lesions at the same level. Atlanto-axial or atlanto-occipital involvement was found in 9 of our 29 patients. Seven had forward slipping of C1 over C2. No instances of vertebral slipping below C1-C2 or of vertebral collapse were recorded.(ABSTRACT TRUNCATED AT 250 WORDS)

Arthritis, Juvenile↗
PubMed1984

[Glomerular nephropathies in untreated rheumatoid arthritis. Review of the literature apropos of 2 cases].

Two cases of classical rheumatoid arthritis complicated by the development of a glomerulopathy independently of drug treatment are presented. Renal biopsy showed membranous glomerulonephritis in one case and fusion of foot processes in the second. The literature is reviewed and the possible relationships between rheumatoid arthritis and these glomerulopathies are discussed. The authors conclude to the absence of causal relationship between these two diseases.

Aged↗
PubMed1984

[Lupus biology: incidence and development in 84 rheumatoid polyarthritis patients treated with D-penicillamine].

Eighty four patients with classical rheumatoid arthritis were treated with 300-1 200 mg/day of D-Penicillamine. During follow-up, attention was paid to various clinical and biological parameters including the antinuclear factor (ANF) and anti-deoxyribonucleic acid (DNA) antibodies. Before therapy the ANF was greater than or equal to 1/50 in 22 patients (26 p. 100); it increased significantly in treated patients (p less than or equal to 0.01). In addition, positive ANF were found in 22 of the 62 patients (35.5 p. 100) who had negative ANF before D-Penicillamine therapy. There was no correlation between the appearance of ANF or the increase in ANF levels and the initial clinical and biological status, tolerance of therapy, the percentage of cases in which D-Penicillamine was effective. Anti-DNA antibodies were found in 5 patients but no clinical signs of lupus disease were observed despite treatment periods of up to 3.5 years in one case. Anti-SM antibodies were also found in one female patient. The disappearance of anti-DNA antibodies after reducing the dosage of D-Penicillamine (1 case) or withdrawal of therapy (2 cases) is an argument in favour of the inducing role of the drug. The incidence, signification and consequences of these observations are analysed and compared with previously reported results.

Adult↗
PubMed1983

[Acute renal insufficiency with ketoprofen and clometacin].

Several recent reports emphasize the adverse effects of non-steroidal antiinflammatory drugs on renal function. These reports incriminate several phenylpropionates but none involve ketoprofen. There have been no indications that clometacin has renal toxicity. We report a case of acute renal failure which occurred during therapy with both ketoprofen and clometacin. The onset of renal failure after their administration, the return to normal renal function once therapy was discontinued and the absence of any other detectable etiology make the responsibility of the treatment very likely. The different possible mechanisms and the role of underlying disease and of associated therapy are discussed. In the index case the reduced excretion of urinary prostaglandin E2 suggests inhibition of prostaglandin synthesis rather than direct drug toxicity or an immuno-allergic mechanism.

Acute Kidney Injury↗